Interactions between Swi1-Swi3, Mrc1 and S phase kinase, Hsk1 may regulate cellular responses to stalled replication forks in fission yeast

Genes to Cells

Volumn 14, Issue 6, 2009, Pages 669-682

  Shimmoto, Michie ^a   Matsumoto, Seiji ^a   Odagiri, Yukari ^a   Noguchi, Eishi ^b   Russell, Paul ^c   Masai, Hisao ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HYDROXYUREA; PROTEIN HSK1; PROTEIN MRC1; PROTEIN SWI; PROTEIN SWI1; PROTEIN SWI3; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL DIVISION; CHROMATIN; CONTROLLED STUDY; FUNGAL GENE; GENE CLUSTER; GENE MUTATION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC REGULATION; IMMUNOPRECIPITATION; NONHUMAN; PHOSPHODEGRONE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; YEAST;

CELL CYCLE PROTEINS; CHROMATIN; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; IMMUNOPRECIPITATION; PROTEIN-SERINE-THREONINE KINASES; S PHASE; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

SCHIZOSACCHAROMYCETACEAE;

EID: 66749154726     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2009.01300.x     Document Type: Article

References (40)

1. Alcasabas, A.A., Osborn, A.J., Bachant, J., Hu, F., Werler, P.J., Bousset, K., Furuya, K., Diffley, J.F., Carr, A.M. & Elledge, S.J. (2001) Mrc1 transduces signals of DNA replication stress to activate Rad53. Nat. Cell Biol. 3, 958-965.
2. Alfa, C., Fantes, P., Hyams, J., McLeod, M. & Warbrick, E. (1993) Experiments with Fission Yeast: A Laboratory Course Manual. Plainview, NY: Cold Spring Harbor Laboratory Press.
3. Bailis, J.M., Bernard, P., Antonelli, R., Allshire, R.C. & Forsburg, S.L. (2003) Hsk1-Dfp1 is required for heterochromatin-mediated cohesion at centromeres. Nat. Cell Biol. 5, 1111-1116.
4. Boddy, M.N. & Russell, P. (2001) DNA replication checkpoint. Curr. Biol. 11, R953-R956.
5. Brown, G.W. & Kelly, T.J. (1999) Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase. Proc. Natl. Acad. Sci. USA 96, 8443-8448.
6. Chou, D.M. & Elledge, S.J. (2006) Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc. Natl. Acad. Sci. USA 103, 18143-18147.
7. Costanzo, V., Shechter, D., Lupardus, P.J., Cimprich, K.A., Gottesman, M. & Gautier, J. (2003) An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell 11, 203-213.
8. Duncker, B.P., Shimada, K., Tsai-Pflugfelder, M., Pasero, P. & Gasser, S.M. (2002) An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing. Proc. Natl. Acad. Sci. USA 99, 16087-16092.
9. Gambus, A., Jones, R.C., Sanchez-Diaz, A., Kanemaki, M., van Deursen, F., Edmondson, R.D. & Labib, K. (2006) GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat. Cell Biol. 8, 358-366.
10. Gotter, A.L. (2003) Tipin, a novel timeless-interacting protein, is developmentally co-expressed with Timeless and disrupts its self-association. J. Mol. Biol. 331, 167-176.
11. Kastan, M.B. & Bartek, J. (2004) Cell-cycle checkpoints and cancer. Nature 432, 316-323.
12. Katou, Y., Kanoh, Y., Bando, M., Noguchi, H., Tanaka, H., Ashikari, T., Sugimoto, K. & Shirahige, K. (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424, 1078-1083.
13. Kearsey, S.E., Montgomery, S., Labib, K. & Lindner, K. (2000) Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18. EMBO J. 19, 1681-1690.
14. Kim, J.M., Kakusho, N., Yamada, M., Kanoh, Y., Takemoto, N. & Masai, H. (2008) Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint. Oncogene 27, 3475-3482.
15. Kim, J.M., Nakao, K., Nakamura, K., Saito, I., Katsuki, M., Arai, K. & Masai, H. (2002) Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. EMBO J. 21, 2168-2179.
16. Mailand, N., Bekker-Jensen, S., Bartek, J. & Lukas, J. (2006) Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol. Cell 23, 307-318.
17. Mamely, I., van Vugt, M.A., Smits, V.A., Semple, J.I., Lemmens, B., Perrakis, A., Medema, R.H. & Freire, R. (2006) Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Curr. Biol. 16, 1950-1955.
18. Masai, H. & Arai, K. (2002) Cdc7 kinase complex: A key regulator in the initiation of DNA replication. J Cell Physiol. 190, 287-296.
19. Masai, H., Matsui, E., You, Z., Ishimi, Y., Tamai, K. & Arai, K. (2000) Human Cdc7-related kinase complex: In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 by Cdks. J. Biol. Chem. 275, 29042-29052.
20. Masai, H., Miyake, T. & Arai, K. (1995) hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication. EMBO J. 14, 3094-3104.
21. Masai, H., Taniyama, C., Ogino, K., Matsui, E., Kakusho, N., Matsumoto, S., Kim, J.M., Ishii, A., Tanaka, T., Kobayashi, T., Tamai, K., Ohtani, K. & Arai, K. (2006) Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. J. Biol. Chem. 281, 39249-39261.
22. Matsumoto, S., Ogino, K., Noguchi, E., Russell, P. & Masai, H. (2005) Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex. J. Biol. Chem. 280, 42536-42542.
23. Nedelcheva, M.N., Roguev, A., Dolapchiev, L.B., Shevchenko, A., Taskov, H.B., Shevchenko, A., Stewart, A.F. & Stoynov, S.S. (2005) Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex. J. Mol. Biol. 347, 509-521.
24. Noguchi, E., Noguchi, C., Du, L.L. & Russell, P. (2003) Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1. Mol. Cell. Biol. 23, 7861-7874.
25. Noguchi, E., Noguchi, C., McDonald, W.H., Yates III, J.R. & Russell, P. (2004) Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol. Cell. Biol. 24, 8342-8355.
26. Ogino, K., Hirota, K., Matsumoto, S., Takeda, T., Ohta, A., Arai, K. & Masai, H. (2006) Hsk1 kinase is required for induction of meiotic dsDNA breaks without involving checkpoint kinases in fission yeast. Proc. Natl. Acad. Sci. USA 103, 8131-8136.
27. Peschiaroli, A., Dorrello, N.V., Guardavaccaro, D., Venere, M., Halazonetis, T., Sherman, N.E. & Pagano, M. (2006) SCFbTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol. Cell 23, 319-329.
28. Sato, N., Arai, K. & Masai, H. (1997) Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: In vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. EMBO J. 16, 4340-4351.
29. Snaith, H.A., Brown, G.W. & Forsburg, S.L. (2000) Schizosaccharomyces pombe Hsk1p is a potential Cds1p target required for genome integrity. Mol. Cell. Biol. 20, 7922-7932.
30. Sommariva, E., Pellny, T.K., Karahan, N., Kumar, S., Huberman, J.A. & Dalgaard, J.Z. (2005) Schizosaccharomyces pombe Swi 1, Swi3, and Hsk1 Are Components of a Novel S-Phase Response Pathway to Alkylation Damage. Mol. Cell. Biol. 25, 2770-2784.
31. + encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage. Mol. Cell. Biol. 19, 5535-5547.
32. Takeda, T., Ogino, K., Tatebayashi, K., Ikeda, H., Arai, K. & Masai, H. (2001) Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast. Mol. Biol. Cell 12, 1257-1274.
33. Tanaka, K. & Russell, P. (2001) Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1. Nat. Cell Biol. 3, 966-972.
34. Unsal-Kacmaz, K., Chastain, P.D., Qu, P.P., Minoo, P., Cordeiro-Stone, M., Sancar, A. & Kaufmann, W.K. (2007) The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol. Cell Biol. 27, 3131-3142.
35. Wang, X., Zou, L., Lu, T., Bao, S., Hurov, K.E., Hittelman, W.N., Elledge, S.J. & Li, L. (2006) Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol. Cell 23, 331-341.
36. Weinreich, M. & Stillman, B. (1999) Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO J. 18, 5334-5346.
37. Yoo, H.Y., Kumagai, A., Shevchenko, A., Shevchenko, A. & Dunphy, W.G. (2004) Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell 117, 575-588.
38. Yoshizawa-Sugata, N. & Masai, H. (2007) Human Tim/ Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. J. Biol. Chem. 282, 2729-2740.
39. Zhao, H. & Russell, P. (2004) DNA binding domain in the replication checkpoint protein Mrc1 of Schizosaccharomyces pombe. J. Biol. Chem. 279, 53023-53027.
40. Zhao, H., Tanaka, K., Noguchi, E., Noguchi, C. & Russell, P. (2003) Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast. Mol. Cell. Biol. 23, 8395-8403.