Relevance of a single dose of 270 ug/kg recombinant factor Vila for the treatment of patients with haemophilia and inhibitors Recommendations from the GTH experts;Stellenwert der Einzelgabe von 270 ug/kg rekom-binantem Faktor Vila in der Behandlung von Hamophilie-Patienten mit Hemmkorpern - Empfehlungen der Experten

Hamostaseologie

Volumn 29, Issue 2, 2009, Pages 197-203

  Auerswald, G ^a   Muntean, W ^b   Kemkes Matthes, B ^c   Klamroth, R ^d   Krause, M ^e   Kurnik, K ^f   Oldenburg, J ^g   Pabinger Fasching, I ^h   Schramm, W ⁱ   Zimmermann, R ^j   Zotz, R B ^k  

^a KLINIKUM BREMEN MITTE   (Germany)

^b Universitatsklinik fur Kinder und Jugendmedizin   (Germany)

^c UNIVERSITY HOSPITAL MARBURG   (Germany)

^d VIVANTES KLINIKUM IM FRIEDRICHSHAIN   (Germany)

^e DEUTSCHE KLINIK FÜR DIAGNOSTIK   (Germany)

^f LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^g UNIVERSITY HOSPITAL BONN   (Germany)

^h MEDICAL UNIVERSITY OF VIENNA   (Austria)

ⁱ UNIVERSITY OF MUNICH   (Germany)

^j SRH Kurpfalzkrankenhaus   (Germany)

^k Praxis für Hämostaseologie und Transfusionsmedizin   (Germany)

more..

Author keywords

Haemophilia; Inhibitors; Recombinant factor Vila; Single dose

Indexed keywords

BLOOD CLOTTING FACTOR 7A INHIBITOR; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ARTICLE; BLEEDING; CLINICAL TRIAL; DRUG EFFECT; DRUG EFFICACY; HEMOPHILIA; HEMOPHILIA A; HEMOPHILIA B; HUMAN; PRESCRIPTION; QUALITY OF LIFE; SINGLE DRUG DOSE; THROMBOEMBOLISM; TREATMENT OUTCOME; TREATMENT RESPONSE;

EID: 66749141613     PISSN: 07209355     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1617025     Document Type: Article

References (12)

1. Auerswald G. Langzeitprophylaxe bei kongenitaler Hamophilie mit Hemmkorpern. Hamostaseologie 2007; 27: 123-128.
2. Bundesarztekammer. Querschnittsleitlinien zur Ther- apie mit Blutkomponenten und Plasmaderivaten. Kapitel 6: Schramm W, Oldenburg J. Faktor VIII- Konzentrate, Faktor VIII / Von Willebrand-Faktor- Konzentrate, Faktor IX-Konzentrate, Aktivierte Pro-thrombin-Komplex-Konzentrate. 2008: 158-189.
3. Cooper HA, Jones CP, Campion E et al. Rational for the use of high dose rFVIIa in a high-titre inhibitor patient with haemophilia B during major orthopaedic procedures. Haemophilia 2001; 7: 517-522.
4. Kavakli K, Makris M, Zulfikar B, Erhardtsen E, Ab- rams ZS, Kenet G for the NovoSeven* trial (F7HAEM-1510) investigators. Home treatment of haemarthroses using a single dose regimen of rec- ombinant activated factor VII in patients with haemophilia and inhibitors. Thromb Haemost 2006; 95: 600-605.
5. Kenet G, Lubetsky A, Luboshitz J, Martinowitz U. A new approach to treatment of bleeding episodes in young hemophilia patients: a single bolus mega-dose of recombinant activated factor VII (NovoSeven*). J Thromb Haemost 2003; 1: 450-455.
6. Key NS, Aledort LM, Beardsley D et al. Home treatment of mild to moderate bleeding episodes using recombinant factor VIIa (Novoseven) in haemophiliacs with inhibitors. Thromb Haemost 1998; 80: 912-918.
7. Konkle BA, Ebbesen LS, Erhardtsen E, Bianco RP, Lissitchkov T, Rusen L, Serban MA. Randomized, prospective clinical trial of recombinant factor VIIa for secondary prophylaxis in hemophilia patients with inhibitors. J Thromb Haemost 2007; 5: 1904-1913.
8. Lorand L. Sol Sherry Lecture in Thrombosis: research on clot stabilization provides clues for improving thrombolytic therapies. Arterioscler Thromb Vasc Biol 2000; 20: 2-9.
9. NovoSeven* Fachinformation, September 2008.
10. Parameswaran R, Shapiro AD, Gill JC, Kessler CM and HTRS Registry investigators. Dose effects and efficacy of rFVIIa in the treatment of haemophilia patients with inhibitors: analysis from the Hemophilia and Thrombosis Research Society Registry. Haemophilia 2005; 11: 100-106.
11. Santagostino E, Mancuso ME, Rocino A, Mancuso G, Scaraggi F, Mannucci PM. A prospective randomized trial of high and standard dosages of rec- ombinant factor VIIa for treatment of hemart- horses in hemophiliacs with inhibitors. J Thromb Haemost 2006; 4: 367-371.
12. -1-dose and APCC for home treatment of joint bleeds in haemophilia patients with inhibitors: a randomized comparison. Haemophilia 2008, 14: 287-294.