Gene expression profiling predicts a three-gene expression signature of endometrial adenocarcinoma in a rat model

Cancer Cell International

Volumn 9, Issue , 2009, Pages

  Karlsson, Sandra ^a   Olsson, Björn ^a   Klinga Levan, Karin ^a  

^a UNIVERSITY OF SKÖVDE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIGLYCAN; COMPLEMENTARY DNA; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 3; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA MICROARRAY; ENDOMETRIUM CARCINOMA; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; GENOTYPE; MOLECULAR CLONING; NONHUMAN; PRECANCER; RAT;

EID: 66749132843     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/1475-2867-9-12     Document Type: Article

References (23)

1. Gruber SB Thompson WD A population-based study of endometrial cancer and familial risk in younger women. Cancer and steroid hormone study group Cancer Epidemiol Biomarkers Prev 1996, 5(6):411-417. 8781735
2. Prat J Prognostic parameters of endometrial carcinoma Hum Pathol 2004, 35(6):649-662. 10.1016/j.humpath.2004.02.007 15188130
3. Bokhman JV Two pathogenetic types of endometrial carcinoma Gynecologic Oncology 1983, 15:10-17. 10.1016/0090-8258(83)90111-7 6822361
4. Deerberg F Kaspareit J Endometrial carcinoma in BD II/Han rats: Model of a spontaneous hormone-dependent tumor J Natl Cancer Inst 1987, 78(6):1245-1251. 3473261
5. Kaspareit-Rittinghausen J Deerberg F Rapp K Mortality and incidence of spontaneous neoplasms in BDII/Han rats Z Versuchstierkd 1987, 30(5-6):209-216. 3445711
6. Vollmer G Endometrial cancer: Experimental models useful for studies on molecular aspects of endometrial cancer and carcinogenesis Endocr Relat Cancer 2003, 10(1):23-42. 10.1677/erc.0.0100023 12653669
7. Roshani L Mallon P Sjostrand E Wedekind D Szpirer J Szpirer C Hedrich HJ Klinga-Levan K Genetic analysis of susceptibility to endometrial adenocarcinoma in the BDII rat model Cancer Genet Cytogenet 2005, 158(2):137-141. 10.1016/j.cancergencyto.2004.08.034 15796960
8. Roshani L Wedekind D Szpirer J Taib Z Szpirer C Beckmann B Riviere M Hedrich HJ Klinga-Levan K Genetic identification of multiple susceptibility genes involved in the development of endometrial carcinoma in a rat model Int J Cancer 2001, 94(6):795-799. 10.1002/ ijc.1553 11745480
9. Karlsson S Holmberg E Askerlund A Levan KK Altered transforming growth factor-beta pathway expression pattern in rat endometrial cancer Cancer Genet Cytogenet 2007, 177(1):43-50. 10.1016/j.cancergencyto.2007.05.010 17693190
10. Dennis G Jr Sherman BT Hosack DA Yang J Gao W Lane HC Lempicki RA DAVID: Database for Annotation, Visualization, and Integrated Discovery Genome Biol 2003, 4(5):P3. 10.1186/gb-2003-4-5-p3 12734009
11. Yu YP Yu G Tseng G Cieply K Nelson J Defrances M Zarnegar R Michalopoulos G Luo JH Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis Cancer Res 2007, 67(17):8043-8050. 10.1158/0008-5472.CAN-07-0648 17804715
12. Lodygin D Epanchintsev A Menssen A Diebold J Hermeking H Functional epigenomics identifies genes frequently silenced in prostate cancer Cancer Res 2005, 65(10):4218-4227. 10.1158/0008-5472.CAN-04-4407 15899813
13. Lee OJ Schneider-Stock R McChesney PA Kuester D Roessner A Vieth M Moskaluk CA El-Rifai W Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis Neoplasia 2005, 7(9):854-861. 10.1593/neo.05328 16229808 1501938
14. Weber CK Sommer G Michl P Fensterer H Weimer M Gansauge F Leder G Adler G Gress TM Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines Gastroenterology 2001, 121(3):657-667. 10.1053/gast.2001.27222 11522750
15. Shintani Y Maeda M Chaika N Johnson KR Wheelock MJ Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling Am J Respir Cell Mol Biol 2008, 38(1):95-104. 10.1165/rcmb.2007-0071OC 17673689 2176131
16. Van Themsche C Mathieu I Parent S Asselin E Transforming growth factor-beta3 increases the invasiveness of endometrial carcinoma cells through phosphatidylinositol 3-kinase-dependent up-regulation of X-linked inhibitor of apoptosis and protein kinase c-dependent induction of matrix metalloproteinase-9 J Biol Chem 2007, 282(7):4794-4802. 10.1074/jbc.M608497200 17150964
17. Gold LI Parekh TV Loss of growth regulation by transforming growth factor-beta (TGF-beta) in human cancers: Studies on endometrial carcinoma Semin Reprod Endocrinol 1999, 17(1):73-92. 10.1055/ s-2007-1016214 10406078
18. Sakaguchi J Kyo S Kanaya T Maida Y Hashimoto M Nakamura M Yamada K Inoue M Aberrant expression and mutations of TGF-beta receptor type II gene in endometrial cancer Gynecol Oncol 2005, 98(3):427-433. 10.1016/ j.ygyno.2005.04.031 15993480
19. Parekh TV Gama P Wen X Demopoulos R Munger JS Carcangiu ML Reiss M Gold LI Transforming growth factor beta signaling is disabled early in human endometrial carcinogenesis concomitant with loss of growth inhibition Cancer Res 2002, 62(10):2778-2790. 12019154
20. Saal LH Troein C Vallon-Christersson J Gruvberger S Borg A Peterson C BioArray Software Environment (BASE): A platform for comprehensive management and analysis of microarray data Genome Biol 2002, 3:8. SOFTWARE0003 10.1186/gb-2002-3-8-software0003 12186655 139402
21. Benjamini Y Hochberg Y Controlling the false discovery rate: A practical and powerful approach to multiple testing Journal of the Royal Statistical Society Series B 1995, 57:289-300.
22. Frank E Hall M Trigg L Holmes G Witten IH Data mining in bioinformatics using Weka Bioinformatics 2004, 20(15):2479-2481. 10.1093/bioinformatics/ bth261 15073010
23. Lachenbruch PaM A Estimation of error rates in discriminat analysis Techometrics 1968, 10:1-11. 10.2307/1266219