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New Medicines Database
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66749167256
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41149118550
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(R)-8-(3-amino-piperidin-1-yl)-7-but-2- Ynyl-3-methyl-1-(4-methyl- quinazolin-2- ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors
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Thomas L, Eckhardt M, Langkopf E, Tadayyon M, Himmelsbach F, Mark M: (R)-8-(3-amino-piperidin-1-yl)-7-but-2- ynyl-3-methyl-1-(4-methyl-quinazolin-2- ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther 325:175-182, 2008
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7
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41649102998
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Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects
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Christopher R, Covington P, Davenport M, Fleck P, Mekki QA, Wann ER, Karim A: Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects. Clin Ther 30:513-527, 2008
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8
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41649083174
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Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: A randomized, double- blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes
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Covington P, Christopher R, Davenport M, Fleck P, Mekki QA, Wann ER, Karim A: Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: a randomized, double- blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes. Clin Ther 30:499-512, 2008
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9
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66749150673
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Efficacy and safety of alogliptin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise
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abstract
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Mekki Q, Fleck P, Wilson C, DeFronzo R: Efficacy and safety of alogliptin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise [abstract]. Diabetologia 51 (Suppl. 1):S344, 2008
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58149249623
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Fleck P, Mekki Q, Kipnes M, Wilson C, Pratley R: Efficacy and safety of alogliptin and glyburide combination therapy in patients with type 2 diabetes [abstract]. Diabetologia 51 (Suppl. 1):S37, 2008
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11
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58149255417
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Rendell M, Rosenstock J, Gross J, Fleck P, Wilson C, Mekki Q: Addition of alogliptin to insulin therapy reduces HbA1c without increasing weight gain or hypoglycaemia in patients with type 2 diabetes [abstract]. Diabetologia 51 (Suppl. 1):S37-S38, 2008
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12
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58149255418
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Pratley R, Reusch J, Fleck P, Wilson C, Mekki Q: Alogliptin added to pioglitazone therapy improves glycaemic control in patients with type 2 diabetes without increasing weight gain or hypoglycaemia [abstract]. Diabetologia 51 (Suppl. 1):S343, 2008
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13
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58149259260
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Alogliptin added to metformin therapy in patients with type 2 diabetes reduces HbA1c without changing weight or increasing gastrointestinal symptoms or hypoglycaemia
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abstract
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Ellis G, Fleck P, Wilson C, Mekki Q, Nauck M: Alogliptin added to metformin therapy in patients with type 2 diabetes reduces HbA1c without changing weight or increasing gastrointestinal symptoms or hypoglycaemia [abstract]. Diabetologia 51 (Suppl. 1):S343-S344, 2008
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40749110245
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The dipeptidyl peptidase-4 inhibitor PHX1149 improves blood glucose control in patients with type 2 diabetes mellitus
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Garcia-Soria G, Gonzalez-Galvez G, Argoud GM, Gerstman M, Littlejohn TW, Schwartz SL, O'Farrell AM, Li X, Cherrington JM, Bennett C, Guler HP: The dipeptidyl peptidase-4 inhibitor PHX1149 improves blood glucose control in patients with type 2 diabetes mellitus. Diab Obes Metab 10:293-300, 2008
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16
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42649121910
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The novel, potent, and selective DPP-IV inhibitor BI 1356 significantly lower HbA1c after only 4 weeks of treatment in patients with type 2 diabetes
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abstract
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Forst T, Uhlig-Laske B, Ring A, Ritzhaupt A, Graefe-Mody U, Dugi KA: The novel, potent, and selective DPP-IV inhibitor BI 1356 significantly lower HbA1c after only 4 weeks of treatment in patients with type 2 diabetes [abstract]. Diabetes 56 (Suppl. 1):A157-158, 2007
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Forst, T.1
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Efficacy Vs. Placebo As Initial Combination Therapy with Pioglitazone
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20
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66749142602
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Boehringer Ingelheim Pharmaceuticals: Safety and efficacy of BI 1356 as monotherapy or in combination in type 2 DM [article online]. Available from http://clinicaltrials. gov/show/NCT00736099 (NLM Identifier: NCT00736099). Accessed 3 December 2008
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Safety and Efficacy of BI 1356 As Monotherapy or in Combination in Type 2 DM
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21
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66749109508
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BI 1356 in Combination with Metformin and a Sulphonylurea in Type 2 Diabetes
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23
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66749113662
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Boehringer Ingelheim Pharmaceuticals: [article online]. Available from (NLM Identifier: NCT00622284). Accessed 3 December 2008
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Boehringer Ingelheim Pharmaceuticals: Efficacy and safety of BI 1356 in combination with metformin in patients with type 2 diabetes [article online]. Available from http://clinicaltrials.gov/show/NCT00622284 (NLM Identifier: NCT00622284). Accessed 3 December 2008
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Efficacy and Safety of BI 1356 in Combination with Metformin in Patients with Type 2 Diabetes
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24
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58149245325
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Initial combination therapy with saxagliptin and metformin improves glycaemic control compared with either monotherapy alone in drug-naive patients with type 2 diabetes
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Chen R, Pfutzner A, Jadzinsky M, Paz-Pacheco E, Xu Z, Allen E: Initial combination therapy with saxagliptin and metformin improves glycaemic control compared with either monotherapy alone in drug-naive patients with type 2 diabetes [abstract]. Diabetologia 51 (Suppl. 1):S38, 2008
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Chen, R.1
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25
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58149256628
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Saxagliptin added to a sulfonylurea is safe and more effective than up-titrating a sulfonylurea in patients with type 2 diabetes
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abstract
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Ravichandran S, Chacra AR, Tan GH, Apanovitch A, Chen R: Saxagliptin added to a sulfonylurea is safe and more effective than up-titrating a sulfonylurea in patients with type 2 diabetes [abstract]. Diabetologia 51 (Suppl. 1):S342, 2008
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Ravichandran, S.1
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26
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58149220720
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Allen E, Hollander P, Li J, Chen R: Saxagliptin added to a thiazolidinedione improves glycaemic control in patients with inadequately controlled type 2 diabetes [abstract]. Diabetologia 51 (Suppl. 1):S342-S343, 2008
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Allen, E.1
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42149194313
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Glucose- Lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes
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66749180788
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18-Week Add-on to Metformin Comparison of Saxagliptin and Sitagliptin
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66749189362
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Safety and Efficacy Study of Saxagliptin Added to Insulin Alone or to Insulin Taken with Metformin
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34
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44949170696
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Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes and mild hyperglycaemia
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Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia
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Scherbaum WA, Schweizer A, Mari A, Nilsson PM, Lalanne G, Wang Y, Dunning BE, Foley JE: Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia. Diabetes Obes Metab 10:1114-1124, 2008
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Management of type 2 diabetes in treatment-naive elderly patients
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Rosenstock J, Kim SW, Baron MA, Camisasca RP, Cressier F, Couturier A, Dejager S: Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab 9:175-185, 2007 (Pubitemid 46206561)
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