Low affinity glucocorticoid binding site ligands as potential anti-fibrogenics

Comparative Hepatology

Volumn 8, Issue , 2009, Pages

  Marek, Carylyn J ^a   Wallace, Karen ^a,b   Durward, Elaine ^a   Koruth, Matthew ^a   Leel, Val ^a   Leiper, Lucy J ^a   Wright, Matthew C ^a,b  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CARBONITRILE; 4 ANDROSTENE 3 ONE 17BETA CARBOXYLIC ACID METHYL ESTER; ANTIFIBROTIC AGENT; CLOTRIMAZOLE; DEXAMETHASONE; HALOPERIDOL; HORMONE RECEPTOR STIMULATING AGENT; LOW AFFINITY GLUCOCORTICOID BINDING SITE LIGAND; METYRAPONE; PREGNANE X RECEPTOR AGONIST; PROGESTERONE; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR MEMBRANE COMPONENT 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; GENE EXPRESSION; HORMONE ACTION; HORMONE BINDING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; LIVER FIBROSIS; LIVER MICROSOME; MALE; MOLECULAR CLONING; MYOFIBROBLAST; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING;

EID: 66749090363     PISSN: None     EISSN: 14765926     Source Type: Journal    
DOI: 10.1186/1476-5926-8-1     Document Type: Article

References (47)

1. Wallace K Burt AD Wright MC Liver fibrosis Biochem J 2008, 411:1-18. 10.1042/BJ20071570 18333835
2. Fallowfield JA Mizuno M Kendall TJ Constandinou CM Benyon RC Duffield JS Iredale JP Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis J Immunol 2007, 178:5288-5295. 17404313
3. Kliewer SA Moore JT Wade L Staudinger JL Watson MA Jones SA McKee DD Oliver BB Willson TM Zetterström RH Perlmann T Lehmann JM An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway Cell 1998, 92:73-82. 10.1016/S0092-8674(00)80900-9 9489701
4. Goodwin B Gauthier KC Umetani M Watson MA Lochansky MI Collins L Leitersdorf E Mangelsdorf DJ Kliewer SA Repa JJ Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor Proc Natl Acad Sci USA 2003, 100:223-228. 140933 12509506 10.1073/pnas.0237082100
5. Goodwin B Redinbo MR Kliewer SA Regulation of cyp3a gene transcription by the pregnane x receptor Annu Rev Pharmacol Toxicol 2002, 42:1-23. 10.1146/annurev.pharmtox.42.111901.111051 11807162
6. Marek CJ Tucker SJ Konstantinou DK Elrick LJ Haefner D Sigalas C Murray GI Goodwin B Wright MC Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms Biochem J 2005, 387:601-608. 1134989 15595924 10.1042/BJ20041598
7. Wright MC The impact of pregnane X receptor activation on liver fibrosis Biochem Soc Trans 2006, 34:1119-1123. 10.1042/BST0341119 17073765
8. Haughton EL Tucker SJ Marek CJ Durward E Leel V Bascal Z Monaghan T Koruth M Collie-Duguid E Mann DA Trim JE Wright MC Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro Gastroenterology 2006, 131:194-209. 10.1053/j.gastro.2006.04.012 16831602
9. Wright MC Paine AJ Induction of the cytochrome P450 3A subfamily in rat liver correlates with the binding of inducers to a microsomal protein Biochem Biophys Res Commun 1994, 201:973-979. 10.1006/bbrc.1994.1797 8003039
10. Wright MC Paine AJ Characteristics of a membrane-associated steroid binding site in rat liver J Recept Signal Transduct Res 1995, 15:543-556. 10.3109/10799899509045239 8903963
11. Wright MC Allenby G Paine AJ Effect of vitamin A deficiency on the expression of low affinity glucocorticoid binding site activity and glucocorticoid-dependent induction of CYP3A2 in rat liver Biochem Biophys Res Commun 1997, 237:211-216. 10.1006/bbrc.1997.7114 9268688
12. Durward E Leel V Haefner D Wright MC Phosphorylation of recombinant human low affinity glucocorticoid binding site recombinant protein in vitro reconstitutes its progesterone binding function Toxicology 2006, 226:51-52. 10.1016/j.tox.2006.05.072
13. Craven RJ Mallory JC Hand RA Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51 J Biol Chem 2007, 282:36543-36551. 10.1074/ jbc.M706770200 17954932
14. Peluso JJ Romak J Liu X Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 mutations Endocrinol 2008, 149:534-543. 10.1210/en.2007-1050
15. Hughes AL Powell DW Bard M Eckstein J Barbuch R Link AJ Espenshade PJ Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes Cell Metab 2007, 5:143-9. 10.1016/j.cmet.2006.12.009 17276356
16. Marek CJ Tucker SJ Koruth M Wallace K Wright MC Expression of CYP2S1 in human hepatic stellate cells FEBS Lett 2007, 581:781-786. 10.1016/ j.febslet.2007.01.056 17280660
17. Leel V Elrick LJ Solares J Ingram N Charlton KA Porter AJ Wright MC Identification of a truncated ratp28-related protein expressed in kidney Biochem Biophys Res Commun 2004, 316:872-877. 10.1016/j.bbrc.2004.02.137 15033482
18. Guendouz F Blanchardie P Denis M Orsonneau JL Lustenberger P Occurrence of glucocorticoid binding sites in solubilized microsomes from rat liver J Steroid Biochem 1989, 34:325-330. 10.1016/0022-4731(89)90102-7 2626026
19. Chirino R Fernández L López A Navarro D Rivero JF Díaz-Chico JC Díaz-Chico BN Thyroid hormones and glucocorticoids act synergistically in the regulation of the low affinity glucocorticoid binding sites in the male rat liver Endocrinology 1991, 129:3118-3124. 1954893
20. Lösel RM Besong D Peluso JJ Wehling M Progesterone receptor membrane component 1 - Many tasks for a versatile protein Steroids 2008, 73:929-934. 10.1016/j.steroids.2007.12.017 18249431
21. Nölte I Jeckel D Wieland FT Sohn K Localization and topology of ratp28, a member of a novel family of putative steroid-binding proteins Biochim Biophys Acta 2000, 1543:123-30. 11087948
22. Krebs CJ Jarvis ED Chan J Lydon JP Ogawa S Pfaff DW A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors Proc Natl Acad Sci USA 2000. 97:12816-12821. 18847 11070092 10.1073/ pnas.97.23.12816
23. Min L Takemori H Nonaka Y Katoh Y Doi J Horike N Osamu H Raza FS Vinson GP Okamoto M Characterization of the adrenal-specific antigen IZA (inner zone antigen) and its role in the steroidogenesis Mol Cell Endocrinol 2004, 215:143-8. 10.1016/j.mce.2003.11.025 15026187
24. Gerdes D Wehling M Leube B Falkenstein E Cloning and tissue expression of two putative steroid membrane receptors Biol Chem 1998, 379:907-11. 9705155
25. Monassier L Bousquet P Sigma receptors: From discovery to highlights of their implications in the cardiovascular system Fundam Clin Pharmacol 2002, 16:1-8. 10.1046/j.1472-8206.2002.00063.x 11903506
26. Meyer C Schmid R Scriba PC Wehling M Purification and partial sequencing of high-affinity progesterone-binsite(s) from porcine liver membranes Eur J Biochem 1996, 239: 726-731. 10.1111/j.1432-1033.1996.0726u.x 8774719
27. Meyer C Schmieding K Falkenstein E Wehling M Are high-affinity progesterone binding site(s) from porcine liver microsomes members of the sigma receptor family? Eur J Pharmacol 1998, 347:293-299. 10.1016/ S0014-2999(98)00103-4 9653896
28. Yamada M Nishigami T Nakasho K Nishimoto Y Miyaji H Relationship between sigma-like site and progesterone-binding site of adult male rat liver microsomes Hepatology 1994, 20:1271-1280. 10.1002/hep.1840200526 7927262
29. Harvey JL Paine AJ Maurel P Wright MC Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: Induction of cytochrome P-450 3A4 Drug Metab Dispos 2000, 28:96-101. 10611146
30. Kumar R Johnson BH Thompson EB Overview of the structural basis for transcription regulation by nuclear hormone receptors Essays Biochem 2004, 40:27-39. 15242337
31. Kampa M Castanas E Membrane steroid receptor signaling in normal and neoplastic cells Mol Cell Endocrinol 2006, 246:76-82. 10.1016/ j.mce.2005.11.018 16420972
32. Lösel RM Besong D Peluso JJ Wehling M Progesterone receptor membrane component 1 - Many tasks for a versatile protein Steroids 2008, 73:929-934. 10.1016/j.steroids.2007.12.017 18249431
33. Hand RA Jia N Bard M Craven RJ Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor Eukaryot Cell 2003, 2:306-317. 154842 12684380 10.1128/EC.2.2.306-317.2003
34. Crudden G Chitti RE Craven RJ Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to chemotherapeutic drugs J Pharmacol Exp Ther 2006, 316:448-455. 10.1124/jpet.105.094631 16234411
35. Oakley F Meso M Iredale JP Green K Marek CJ Zhou X May MJ Millward-Sadler H Wright MC Mann DA Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis Gastroenterology 2005, 128:108-120. 10.1053/j.gastro.2004.10.003 15633128
36. Greupink R Bakker HI Reker-Smit C van Loenen-Weemaes AM Kok RJ Meijer DK Beljaars L Poelstra K Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell J Hepatol 2005, 43:884-892. 10.1016/j.jhep.2005.04.014 16083988
37. Hagens WI Mattos A Greupink R de Jager-Krikken A Reker-Smit C van Loenen-Weemaes A Gouw IA Poelstra K Beljaars L Targeting 15d-prostaglandin J2 to hepatic stellate cells: Two options evaluated Pharm Res 2007, 24:566-574. 1915609 17245650 10.1007/s11095-006-9175-2
38. Rachmawati H Reker-Smit C Lub-de Hooge MN van Loenen-Weemaes A Poelstra K Beljaars L Chemical modification of interleukin-10 with mannose 6-phosphate groups yields a liver-selective cytokine Drug Metab Dispos 2007, 35:814-821. 10.1124/dmd.106.013490 17312017
39. Hagens WI Beljaars L Mann DA Wright MC Julien B Lotersztajn S Reker-Smit C Poelstra K Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers J Pharmacol Exp Ther 2008, 324:902-910. 10.1124/jpet.107.132290 18077624
40. Elrick LJ Leel V Blaylock MG Duncan L Drever MR Strachan G Charlton KA Koruth M Porter AJ Wright MC Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells - a potential mechanism for targeting liver anti-fibrotic therapeutics J Hepatol 2005, 42:888-896. 10.1016/j.jhep.2005.01.028 15885360
41. Douglass A Wallace K Parr R Park J Durward E Broadbent I Barelle C Porter AJ Wright MC Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury J Hepatol 2008, 49:88-98. 10.1016/ j.jhep.2008.01.032 18394744
42. Douglass A Wallace K Koruth M Barelle C Porter AJ Wright MC Targeting liver myofibroblasts: A novel approach in anti-fibrogenic therapy Hepatol Int 2008, 2:405-415. 10.1007/s12072-008-9093-y
43. Henderson NC Forbes SJ Hepatic fibrogenesis: From within and outwith Toxicology 2008, 254:130-135. 10.1016/j.tox.2008.08.017 18824072
44. De Minicis S Seki E Uchinami H Kluwe J Zhang Y Brenner DA Schwabe RF Gene expression profiles during hepatic stellate cell activation in culture and in vivo Gastroenterology 2007, 132:1937-1946. 10.1053/ j.gastro.2007.02.033 17484886
45. Orr JG Leel V Cameron GA Marek CJ Haughton EL Elrick LJ Trim JE Hawksworth GM Halestrap AP Wright MC Mechanism of action of the antifibrogenic compound gliotoxin in rat liver cells Hepatology 2004, 40:232-242. 10.1002/hep.20254 15239107
46. Wright MC Issa R Smart DE Trim N Murray GI Primrose JN Arthur MJ Iredale JP Mann DA Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats Gastroenterology 2001, 121:685-98. 10.1053/gast.2001.27188 11522753
47. Vogel S Piantedosi R Frank J Lalazar A Rockey DC Friedman SL Blaner WS An immortalized rat liver stellate cell line (HSC-T6): A new cell model for the study of retinoid metabolism in vitro J Lipid Res 2000, 41:882-893. 10828080