Leukotriene B 4 release by human lung macrophages via receptor- not voltage- operated Ca 2+ channels

European Respiratory Journal

Volumn 33, Issue 5, 2009, Pages 1105-1112

  Finney Hayward, T K ^a   Bahra, P ^b   Li, S ^b   Poll, C T ^b   Nicholson, A G ^a   Russell, R E K ^c   Ford, P A ^a   Westwick, J ^b   Fenwick, P S ^a   Barnes, P J ^a   Donnelly, L E ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b Novartis Institutes for BioMeCical Research   (United Kingdom)

^c Chest Clinic   (United Kingdom)

Author keywords

Ca 2 transients; Leukotriene B 4; Macrophage

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; 2 (3,4 DIHYDRO 6,7 DIMETHOXY 1 ISOQUINOLINYL) 2 PHENYL N,N BIS[2 (2,3,4 TRIMETHOXYPHENYL)ETHYL]ACETAMIDE; CALCIUM ION; ECONAZOLE; EGTAZIC ACID; GADOLINIUM; LEUKOTRIENE B4; NIFEDIPINE; THROMBOCYTE ACTIVATING FACTOR; VOLTAGE GATED CALCIUM CHANNEL; CALCIUM CHANNEL; CALCIUM SENSING RECEPTOR;

AGED; ARTICLE; CALCIUM TRANSPORT; CELL ISOLATION; CELL STIMULATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS MACROPHAGE; LUNG RESECTION; MONOCYTE; PRIORITY JOURNAL; ADULT; AREA UNDER THE CURVE; BIOASSAY; CALCIUM SIGNALING; FEMALE; FORCED EXPIRATORY VOLUME; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; SMOKING;

ADULT; AREA UNDER CURVE; BIOLOGICAL ASSAY; CALCIUM CHANNELS; CALCIUM SIGNALING; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LEUKOTRIENE B4; MACROPHAGES, ALVEOLAR; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, CALCIUM-SENSING; SMOKING;

EID: 66749088061     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00062708     Document Type: Article

References (34)

1. Barnes PJ. New concepts in chronic obstructive pulmonary disease. Annu Rev Med 2003; 54: 113-129.
2. Lopez AD, Murray CC. The global burden of disease, 1990-2020. Nat Med 1998; 4: 1241-1243.
3. Jeffery PK. Comparison of the structural and inflammatory features of COPD and asthma. Giles F. Filley Lecture. Chest 2000; 117: Suppl. 1, 251S-260S.
4. Stockley RA. Neutrophils and the pathogenesis of COPD. Chest 2002; 121: Suppl. 5, 151S-155S.
5. Keatings VM, Evans DJ, O'Connor BJ, Barnes PJ. Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid. Thorax 1997; 52: 372-374.
6. Crooks SW, Bayley DL, Hill SL, Stockley RA. Bronchial inflammation in acute bacterial exacerbations of chronic bronchitis: the role of leukotriene B4. Eur Respir J 2000; 15:274-280.
7. Woolhouse IS, Bayley DL, Stockley RA. Sputum chemotactic activity in chronic obstructive pulmonary disease: effect of alpha(1)-antitrypsin deficiency and the role of leukotriene B(4) and interleukin 8. Thorax 2002; 57: 709-714.
8. Tanino M, Betsuyaku T, Takeyabu K, et al. Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema. Thorax 2002; 57: 405-411.
9. Martin TR, Raugi G, Merritt TL, Henderson WR Jr. Relative contribution of leukotriene B4 to the neutrophil chemo- tactic activity produced by the resident human alveolar macrophage. J Clin Invest 1987; 80: 1114-1124.
10. Laviolette M, Coulombe R, Picard S, Braquet P, Borgeat P. Decreased leukotriene B4 synthesis in smokers' alveolar macrophages in vitro. J Clin Invest 1986; 77: 54-60.
11. Schaberg T, Haller H, Rau M, Kaiser D, Fassbender M, Lode H. Superoxide anion release induced by platelet- activating factor is increased in human alveolar macro- phages from smokers. Eur Respir J 1992; 5: 387-393.
12. Shindo K, Koide K, Fukumura M. Platelet-activating factor increases leukotriene B4 release in stimulated alveolar macrophages from asthmatic patients. Eur Respir J 1998; 11:1098-1104.
13. Marian E, Baraldo S, Visentin A, et al. Up-regulated membrane and nuclear leukotriene B4 receptors in COPD. Chest 2006; 129: 1523-1530.
14. Kilfeather S. 5-Lipoxygenase inhibitors for the treatment of COPD. Chest 2002; 121: Suppl. 5, 197S-200S.
15. Schaberg T, Haller H, Lode H. Evidence for a platelet- activating factor receptor on human alveolar macrophages. Biochem Biophys Res Commun 1991; 177: 704-710.
16. Letari O, Malgaroli A, Morgan DW, Welton AF, Nicosia S. Cytosolic calcium ion and arachidonic acid release and metabolism in macrophages. Eur J Pharmacol 1991; 206: 211-219.
17. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. American Thoracic Society. Am J Respir Crit Care Med 1995; 152: S77-S121.
18. Traves SL, Smith SJ, Barnes PJ, Donnelly LE. Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2. J Leukoc Biol 2004; 76: 441-450.
19. Smith SJ, Cieslinski LB, Newton R, et al. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol Pharmacol 2004; 66: 1679-1689.
20. Smith SJ, Fenwick PS, Nicholson AG, et al. Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages. Br J Pharmacol 2006; 149: 393-404.
21. Ortega MP, Garcia MC, Gijon MA, et al. 1,4- Dihydropyridines, a new class of platelet-activating factor receptor antagonists: in vitro pharmacologic studies. J Pharmacol Exp Ther 1990; 255: 28-33.
22. Krautwurst D, Hescheler J, Arndts D, Losel W, Hammer R, Schultz G. Novel potent inhibitor of receptor-activated nonselective cation currents in HL-60 cells. Mol Pharmacol 1993; 43: 655-659.
23. Tudhope SJ, Finney-Hayward TK, Nicholson AG, et al. Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage. J Pharmacol Exp Ther 2008; 324: 306-312.
24. 2+ release. FASEB J 2002; 16: 1145-1150.
25. Krump E, Pouliot M, Naccache PH, Borgeat P. Leukotriene synthesis in calcium-depleted human neutrophils: arachi- donic acid release correlates with calcium influx. Biochem J 1995; 310: 681-688.
26. Pons AR, Sauleda J, Noguera A, et al. Decreased macro- phage release of TGF-b and TIMP-1 in chronic obstructive pulmonary disease. Eur Respir J 2005; 26: 60-66.
27. Conrad GW, Rink TJ. Platelet activating factor raises intracellular calcium ion concentration in macrophages. J Cell Biol 1986; 103: 439-450.
28. ++ response between hamster and guinea pig alveolar macrophages. J Pharmacol Exp Ther 1997; 281: 1047-1058.
29. Centemeri C, Colli S, Tosarello D, Ciceri P, Nicosia S. Heterogeneous platelet-activating factor (PAF) receptors and calcium increase in platelets and macrophages. Biochemical Pharmacology 1999; 57: 263-271.
30. 2+ transport pathways in thymic lymphocytes by econazole, micona-zole, and SKF 96365. Am J Physiol Cell Physiol 1993; 264: C654-C662.
31. Merritt JE, Armstrong WP, Benham CD, et al. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem J 1990; 271: 515-522.
32. Franzius D, Hoth M, Penner R. Non-specific effects of calcium entry antagonists in mast cells. Pflugers Arch 1994;428: 433-438.
33. Gallin EK. Ion channels in leukocytes. Physiol Rev 1991; 71:775-811.
34. Mao JT, Tsu IH, Dubinett SM, et al. Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 Inhibitors and lipopolysaccharide. Clin Cancer Res 2004; 10:6872-6878.