Insulitis in type 1 diabetes: A sticky problem

Diabetes

Volumn 58, Issue 6, 2009, Pages 1257-1258

  In't Veld, Peter ^a  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTEGRIN; BETA2 INTEGRIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

AUTOIMMUNITY; CELL HOMING; CELLULAR IMMUNITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTIC INFILTRATION; NONHUMAN; NONOBESE DIABETIC MOUSE; NOTE; PANCREAS ISLET; PRIORITY JOURNAL;

ANIMALS; CYTOSKELETAL PROTEINS; DIABETES MELLITUS, TYPE 1; HUMANS; INTEGRINS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; MICE, INBRED NOD; MUSCLE PROTEINS;

EID: 66649135260     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0345     Document Type: Note

References (19)

1. Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965;14:619-633
2. Bottazzo GF, Dean BM, McNally JM, MacKay EH, Swift PGF, Gamble DR. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 1985;313:353-360
3. Wilcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG. Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol 2008;155:173-181
4. Dotta F, Censini S, van Halteren AGS, Marseli L, Masini M, Dionisi S, Mosca F, Boggi U, Onetti Muda A, Del Prato S, Elliott JF, Covacci A, Rappuoli R, Roep BO, Marchetti P. Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A 2007;104:5115-5120 (Pubitemid 47186185)
5. Skowera A, Ellis RJ, Varela-Calvino R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Alen JS, Tree TIM, Zhao M, Dayan CM, Sewell AK, Unger W, Drijfhout JW, Ossendorp F, Roep BO, Peakman M. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated prepropinsulin epitope. J Clin Invest 2008;118:3390-13271
6. Pipeleers D, Ling Z. Pancreatic beta cells in insulin-dependent diabetes. Diabetes Metab Rev 1992;8:209-227 (Pubitemid 23053236)
7. In't Veld P, Lievens D, De Grijse J, Ling Z, Van der Auwera B, Pipeleers- Marichal M, Gorus F, Pipeleers D. Screening for insulitis in adult autoantibody- positive organ donors. Diabetes 2007;56:2400-2404
8. Roep BO, Atkinson M, von Herrath M. Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes. Nat Rev 2004;4:989-997
9. Glawe JD, Patrick DR, Huang M, Sharp CD, Barlow SC, Kevil CG. Genetic deficiency of Itgb2 or ItgaL prevents autoimmune diabetes through distinctly different mechanisms in NOD/LtJ mice. Diabetes 2009;58:1292-1301
10. Barreiro O, de la Fuente H, Mittelbrunn M, Sanchez-Madrid F. Functional insights on the polarized redistribution of leucocyte integrins and their ligands during leucocyte migration and immune interactions. Immunol Rev 2007;218:147-164 (Pubitemid 47052299)
11. Jansen A, Homo-Delarche F, Hooijkaas H, Leenen PJ, Dardenne M, Drexhage HA. Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and β-cell destruction in NOD mice. Diabetes 1994;43:667-675 (Pubitemid 24138780)
12. Otonkoski T, Banerjee M, Korsgren O, Thorn LE, Virtanen I. Unique basement membrane structure of human pancreatic islets: implications for beta cell growth and differentiation. Diabetes Obes Metab 2008;10(Suppl. 4):119-127
13. Hänninen A, Jalkanen S, Samli M, Toikkanen S, Nikolarakos G, Simell O. Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus. J Clin Invest 1992;90:1901-1910
14. Somoza N, Vargas F, Roura-Mir C, Vives-Pi M, Fernandez-Figuereas MT, Ariza A, Gomis R, Bragado R, Marti M, Jaraquemada D, Pujol-Borrell R. Pancreas in recent-onset insulin-dependent diabetes mellitus: changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile. J Immunol 1994;153:1360-1377 (Pubitemid 24228529)
15. Baron JL, Reich EP, Visintin I, Janeway CA. The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1. J Clin Invest 1994;93:1700-1708 (Pubitemid 24116411)
16. Yang XD, Michie SA, Tisch R, Karin N, Steinman L, McDevitt HO. A predominant role of integrin alpha4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A 1994;91:12604-12608
17. Hänninen A, Nurmela R, Maksimow M, Heino J, Jalkanen S, Kurts C. Islet beta-cell-specific T cells can use different homing mechanisms to infiltrate and destroy pancreatic islets. Am J Pathol 2007;170:240-250 (Pubitemid 47339203)
18. Kluger N, Girard C, Gonzalez V, Guillot B, Bessis D. Efalizumab-induced aseptic meningitis. Br J Dermatol 2007;156:189-191 (Pubitemid 44924176)
19. Wendt M, Wohlrab J, Zierz S, Deschauer M. Efalizumab-induced isolated cerebral lupus-like syndrome. Neurology 2009;72:96-97