The G191R variant in the PRSS2 gene does not play a role in protection against tropical calcific pancreatitis

Gut

Volumn 58, Issue 6, 2009, Pages 881-882

  Mahurkar, S ^a,b   Bhaskar, S ^a   Reddy, D N ^b   Rao, G V ^b   Singh, S P ^c   Thomas, V ^d   Chandak, G R ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b ASIAN INSTITUTE OF GASTROENTEROLOGY   (India)

^c SCB MEDICAL COLLEGE   (India)

^d GOVERNMENT MEDICAL COLLEGE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHRONIC PANCREATITIS; GENE; GENE FREQUENCY; GENOTYPE; HUMAN; LETTER; PRIORITY JOURNAL; PRSS2 GENE; TROPICAL CALCIFIC PANCREATITIS;

ASIAN CONTINENTAL ANCESTRY GROUP; CALCINOSIS; CASE-CONTROL STUDIES; GENOTYPE; HUMANS; INDIA; MUTATION; PANCREATITIS; TRYPSIN; TRYPSINOGEN;

EID: 66649128705     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2008.170753     Document Type: Letter

References (13)

1. Witt H, Sahin-Tóth M, Landt O, et al. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. Nat Genet 2006;38:668-673 (Pubitemid 43927309)
2. Santhosh S, Witt H, te Morsche RH, et al. A loss of function polymorphism (G191R) of anionic trypsinogen (PRSS2) confers protection against chronic pancreatitis. Pancreas 2008;36:317-320
3. Kume K, Masamune A, Takagi Y, et al. A loss-of-function anionic trypsinogen (PRSS2) variant in Japanese patients with pancreatic disorders. Gut 2009;58:820-824
4. Chandak GR, Idris MM, Reddy DN, et al. Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis. J Med Genet 2002;39:347-351 (Pubitemid 34526356)
5. Chandak GR, Idris MM, Reddy DN, et al. Absence of PRSS1 mutations and association of SPINK1trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis. Gut 2004;53:723-728 (Pubitemid 38561452)
6. Witt H, Bhatia E. Genetic aspects of tropical calcific pancreatitis. Rev Endocr Metab Disord 2008;9:213-226
7. Mahurkar S, Idris MM, Reddy DN, et al. Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. Gut 2006;55:1270-1275 (Pubitemid 44304037)
8. Rosendahl J, Witt H, Szmola R, et al. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet 2008;40:78-82.
9. Masson E, Le Maréchal C, Chandak GR, et al. Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitis. Clin Gastroenterol Hepatol 2008;6:82-88
10. Weiss FU, Behn CO, Simon P, et al. Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in European patients. Gut 2007;56:1322-1323 (Pubitemid 47300439)
11. Go VL, Hofmann AF, Summerskill WH. Pancreozymin bioassay in man based on pancreatic enzyme secretion: potency of specific amino acids and other digestive products. J Clin Invest 1970;49:1558-1564
12. Balakrishnan V, Sauniere JF, Hariharan M, et al. Diet, pancreatic function and chronic pancreatitis in South India and France. Pancreas 1988;3:30-35 (Pubitemid 18225431)
13. Kukor Z, Tóth M, Sahin-Tóth M. Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases. Eur J Biochem 2003;270:2047-2058 (Pubitemid 36560827)