Mathematical modeling of reflectance and intrinsic fluorescence for cancer detection in human pancreatic tissue

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 7187, Issue , 2009, Pages

  Wilsona, Robert H ^a   Chandraa, Malavika ^a   Scheiman, James ^a,b   Simeone, Diane ^a,b   McKennae, Barbara ^b   Purdye, Julianne ^b   Mycek, Mary Ann ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Fluorescence spectroscopy; Intrinsic fluorescence; Light propagation in tissues; Optical diagnostics; Photon transport in tissues; Reflectance spectroscopy; Tissue diagnostics

Indexed keywords

INTRINSIC FLUORESCENCE; LIGHT PROPAGATION IN TISSUES; OPTICAL DIAGNOSTICS; PHOTON TRANSPORT IN TISSUES; REFLECTANCE SPECTROSCOPY; TISSUE DIAGNOSTICS;

ABSORPTION; BEVERAGES; FISH; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; HISTOLOGY; LIGHT PROPAGATION; LIGHT SCATTERING; PHOTONS; REFLECTION; REFRACTION; SPECTRUM ANALYSIS;

TISSUE;

EID: 66649112740     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (19)

1. Yeo, T. P. et al., "Pancreatic Cancer." Curr. Prob. Cancer 26, 176-275 (2002).
2. Abraham, S. C. et al., "Pancreaticoduodenectomy (Whipple Resections) in Patients Without Malignancy: Are They All 'Chronic Pancreatitis'?" Am. J. Surg. Path. 27, 110-120 (2003). (Pubitemid 36014904)
3. Volynskaya, Z. et al., "Diagnosing breast cancer using diffuse reflectance and intrinsic fluorescence spectroscopy." J. Biomed. Opt. 13, 024012 (2008).
4. Zhu, C., Breslin, T. M., Harter, J., and Ramanujam, N., "Model based and empirical spectral analysis for the diagnosis of breast cancer." Opt. Expr. 16, 14961-14978 (2008).
5. Weber, C. R. et al., "Model-based analysis of reflectance and fluorescence spectra for in vivo detection of cervical dysplasia and cancer." J. Biomed. Opt. 13, 064016 (2008).
6. Zonios, G. et al., "Diffuse reflectance spectroscopy of adenomatous colon polyps in vivo." Appl. Opt. 38, 6628-6637 (1999). (Pubitemid 129567570)
7. Georgakoudi, I. and Feld, M. S., "The combined use of fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in Barrett's esophagus." Gastroint. Endosc. Clin. N. Am. 14, 519-537 (2004). (Pubitemid 38903216)
8. Amelink, A. et al., "Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy." Oral Oncology 44, 65-71 (2008). (Pubitemid 350251281)
9. Schwarz, R. A. et al., "Autofluorescence and diffuse reflectance spectroscopy of oral epithelial tissue using a depthsensitive fiber-optic probe." Appl. Opt. 47, 825-834 (2008).
10. Pavlova, I. et al., "Monte Carlo model to describe depth selective fluorescence spectra of epithelial tissue: applications for diagnosis of oral precancer." J. Biomed. Opt. 13, 064012 (2008).
11. Chandra, M. et al., "Probing pancreatic disease using tissue optical spectroscopy." J. Biomed. Opt. 12, 060501 (2007).
12. Chandra, M. et al., "Pancreatic tissue assessment using fluorescence and diffuse reflectance spectroscopy." Proc. SPIE 6628, 66281R (2007), 8 pgs.
13. Chandra, M. et al., "Quantitative molecular sensing in biological tissues: an approach to non-invasive optical characterization." Opt. Expr. 14, 6157-6171 (2006).
14. Stamatas, G. N., Wu, J., and Kollias, N., "Non-invasive method for quantitative evaluation of exogenous compound deposition on skin." J. Invest. Dermatol. 118, 295-302 (2002). (Pubitemid 34158484)
15. Müller, M. G., Georgakoudi, I., Zhang, Q., Wu, J., and Feld, M. S., "Intrinsic fluorescence spectroscopy in turbid media: disentangling effects of scattering and absorption." Appl. Opt. 40, 4633-4646 (2001).
16. Prahl, S., "Optical Absorption of Hemoglobin." Oregon Medical Laser Center. http://omlc.ogi.edu/spectra/hemoglobin.
17. Zonios, G., Bassukas, I., and Dimou, A., "Comparative evaluation of two simple diffuse reflectance models for biological tissue applications." Appl. Opt. 47, 4965-4973 (2008).
18. Hull, E. L. and Foster, T. H., "Steady-state reflectance spectroscopy in the P3 approximation." J. Opt. Soc. Am. A 18, 584-599 (2001).
19. Finlay, J. C. and Foster, T. H., "Hemoglobin oxygenation saturations in phantoms and in vivo from measurements of steady-state diffuse reflectance at a single, short source-detector separation." Med. Phys. 31, 1949-1959 (2004). (Pubitemid 38924813)