Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis

The Lancet

Volumn 373, Issue 9680, 2009, Pages 2034-2040

  Norman, Jane E ^a   Mackenzie, Fiona ^b   Owen, Philip ^b   Mactier, Helen ^b   Hanretty, Kevin ^c   Cooper, Sarah ^d   Calder, Andrew ^a   Mires, Gary ^e   Danielian, Peter ^f   Sturgiss, Stephen ^g   MacLennan, Graeme ^h   Tydeman, Graham ⁱ   Thornton, Steven ^j   Martin, Bill ^k   Thornton, James G ^l   Neilson, James P ^m   Norrie, John ^c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b Princess Royal Maternity ^*  (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF DUNDEE   (United Kingdom)

^f ABERDEEN MATERNITY HOSPITAL   (United Kingdom)

^g ROYAL VICTORIA INFIRMARY   (United Kingdom)

^h UNIVERSITY OF ABERDEEN   (United Kingdom)

ⁱ NHS FIFE   (United Kingdom)

^j UNIVERSITY OF WARWICK   (United Kingdom)

^k BIRMINGHAM WOMEN S HOSPITAL   (United Kingdom)

^l NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^m LIVERPOOL WOMEN S HOSPITAL   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYPROGESTERONE CAPROATE; PLACEBO; PROGESTERONE;

ACNE; ADULT; ARTHRALGIA; ARTICLE; BLOATING; BREAST TENDERNESS; CESAREAN SECTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELIVERY; DEPRESSION; DIZZINESS; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG HYPERSENSITIVITY; FEMALE; FETUS DEATH; FLUID RETENTION; FOLLOW UP; FORCEPS DELIVERY; GESTATIONAL AGE; HAIR GROWTH; HAIR LOSS; HEADACHE; HUMAN; JAUNDICE; MAJOR CLINICAL STUDY; META ANALYSIS; NAUSEA; PREMATURE LABOR; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RASH; SIDE EFFECT; SLEEP DISORDER; SYSTEMATIC REVIEW; TREATMENT DURATION; TWIN PREGNANCY; UNITED KINGDOM; VAGINA DISCHARGE; VAGINA DISEASE; VAGINAL DISCOMFORT; VAGINAL PRURITUS; WEIGHT GAIN;

EID: 66649092312     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(09)60947-8     Document Type: Article

References (15)

1. Information Services Division, NHS National Services Scotland. Births and babies (2008), NHS National Services Scotland, Edinburgh
2. Office of National Statistics. Birth statistics, review of the National Statistician on births and patterns of family building in England and Wales, 2007 (2008), Office for National Statistics, Newport
3. Scottish programme for clinical effectiveness in reproductive health. Scottish Perinatal and Infant Mortality and Morbidity Report, 2006 (2007), Information Services Division, NHS Scotland, Edinburgh
4. Henderson J., Hockley C., Petrou S., Goldacre M., and Davidson L. Economic implications of multiple births: inpatient hospital costs in the first 5 years of life. Arch Dis Child 89 (2004) F542-F545
5. Hack M. Young adult outcomes of very-low-birth-weight children. Semin Fetal Neonatal Med 11 (2006) 127-137
6. da Fonseca E.B., Bittar R.E., Carvalho M.H., and Zugaib M. Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study. Am J Obstet Gynaecol 188 (2003) 419-424
7. Meis P.J., Klebanoff M., Thom E., et al. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med 348 (2003) 2379-2385
8. Fonseca E.B., Celik E., Parra M., et al. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med 357 (2007) 462-469
9. Dodd J.M., Flenady V.J., Cincotta R., and Crowther C.A. Progesterone for the prevention of preterm birth: a systematic review. Obstet Gynecol 112 (2008) 127-134
10. Jadad A.R., Moore R.A., Carroll D., et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Controlled Clin Trials 17 (1996) 1-12
11. Rouse D.J., Caritis S.N., Peaceman A.M., et al. A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in twins. N Engl J Med 357 (2007) 454-461
12. Hartikainen-Sorri A.L., Kauppila A., and Tuimala R. Inefficacy of 17 alpha-hydroxyprogesterone caproate in the prevention of prematurity in twin pregnancy. Obstet Gynecol 56 (1980) 692-695
13. Dodd J.M., Crowther C.A., Cincotta R., Flenady V., and Robinson J.S. Progesterone supplementation for preventing preterm birth: a systematic review and meta-analysis. Acta Obstet Gynecol Scand 84 (2005) 526-533
14. Ruddock N.K., Shi S.Q., Jain S., et al. Progesterone, but not 17-alpha-hydroxyprogesterone caproate, inhibits human myometrial contractions. Am J Obstet Gynecol 391 (2008) e1-e7 199:
15. Caritis S.N., Rouse D.J., Peaceman A.M., et al. Prevention of preterm birth in triplets using 17 alpha-hydroxyprogesterone caproate: a randomized controlled trial. Obstet Gynecol 113 (2009) 285-292