Thrombin generation test in microfluidic systems

Journal of Applied Physics

Volumn 105, Issue 10, 2009, Pages

  Koch, Kaspar ^a   Van Berkel, Sander S ^a   Van De Wal, Marloes M E B ^a   Nieuwland, Pieter J ^a   Van Hest, Jan C M ^a   Rutjes, Floris P J T ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CONVENTIONAL MONITORING; COST-EFFICIENT; DETECTION LIMITS; DIAGNOSTIC TESTS; MICRO FLUIDIC SYSTEM; MICRO MIXERS; MICRO-FLUIDIC DEVICES; MICROCHANNEL SURFACES; MIXING BEHAVIORS; ON-CHIP MIXING; PROTEIN-SURFACE INTERACTIONS; SCALING DOWN; THROMBIN GENERATION; UNIVERSAL METHOD; VOLUME REDUCTIONS;

FLUIDIC DEVICES; HYDROPHILICITY; MICROCIRCULATION; TESTING;

MICROCHANNELS;

EID: 66549125812     PISSN: 00218979     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.3116634     Document Type: Article

References (26)

1. World Health Organization Factsheet 2002 online (http://www.who.int/ mediacentre/factsheets/fs310/en/index.html).
2. P. Yager, T. Edwards, E. Fu, K. Helton, K. Nelson, M. R. Tam, and B. H. Weigl, Nature (London) 0028-0836 10.1038/nature05064 442, 412 (2006).
3. H. C. Hemker, P. L. A. Giesen, M. Ramjee, R. Wagenvoord, and S. B́guin, Thromb. Haemostasis 0340-6245 83, 589 (2000).
4. V. Chantarangkul, M. Clerici, C. Bressi, P. L. A. Giesen, and A. Tripodi, Haematologica 88, 547 (2003).
5. H. C. Hemker, P. Giesen, R. Al Dieri, V. Regnault, E. de Smedt, R. Wagenvoord, T. Lecompte, and S. B́guin, Pathophysiol. Haemost. Thromb. 33, 4 (2003). 1424-8832 10.1159/000071636
6. P. von Lode, Clin. Biochem. 0009-9120 38, 591 (2005). 10.1016/j.clinbiochem.2005.03.008
7. C. P. Price, BMJ 0959-8138 322, 1285 (2001). 10.1136/bmj.322.7297.1285
8. A. Manz, N. Graber, and H. M. Widmer, Sens. Actuators B 0925-4005 10.1016/0925-4005(90)80209-I 1, 244 (1990).
9. S. Haeberle and R. Zengerle, Lab Chip 1473-0197 10.1039/b706364b 7, 1094 (2007).
10. C. Haber, Lab Chip 1473-0197 10.1039/b610250f 6, 1118 (2006).
11. R. Irawan, C. Tjin Swee, P. Yager, and D. Zhang, Biomed. Microdevices 1387-2176 7, 205 (2005). 10.1007/s10544-005-3027-4
12. C. T. Schembri, T. L. Burd, A. R. Kopfsill, L. R. Shea, and B. Braynin, J. Autom. Chem. 17, 99 (1995).
13. S. Haeberle, T. Brenner, R. Zengerle, and J. Ducŕe, Lab Chip 1473-0197 10.1039/b604145k 6, 776 (2006).
14. S. Yang, A. Undar, and J. D. Zahn, ASAIO J. 1058-2916 10.1097/01.mat.0000178962.69695.b0 51, 585 (2005); S. Yang, A. Undar, and J. D. Zahn, Lab Chip 1473-0197 10.1039/b516401j 6, 871 (2006).
15. X. Yang, A. Hibara, K. Sato, M. Tokeshi, K. Morishima, Y. Kikutani, H. Kimura, T. Kitamori, Special Publication-Royal Society of Chemistry., 296, Proceedings of Micro Total Analysis Systems, Volume 1, p. 120 (2004).
16. H. Song, H. -W. Li, M. S. Munson, T. G. Van Ha, and R. F. Ismagilov, Anal. Chem. 0003-2700 10.1021/ac0601718 78, 4839 (2006).
17. H. K. Trieu, M. Bollerott, M. Kemmerling, R. Hilderbrand, J. C. M. van Hest, F. P. J. T. Rutjes, K. Koch, P. J. Nieuwland, T. A. van Beek, E. J. R. Südholter, R. M. Boom, and A. E. M. Janssen, WO Patent No. 2007016931 (15 February 2007).
18. S. Wielders, M. Mukherjee, J. Michiels, D. T. S. Rijkers, J. P. Cambus, R. W. Knebel, V. Kakkar, H. C. Hemker, and S. B́guin, Thromb. Haemostasis 0340-6245 77, 629 (1997).
19. The total volume of plasma and reagents needed to conduct the TGT in the micromixer was rather large due to the fact that relatively large syringes and tubing were used. This can easily be downscaled to very small volumes and will be subject of investigation in future research.
20. D. T. S. Rijkers, S. J. H. Wielders, S. B́guin, and H. C. Hemker, Thromb. Res. 0049-3848 89, 161 (1998). 10.1016/S0049-3848(97)00312-5
21. See EPAPS Document No. E-JAPIAU-105-044992 for an example for the mathematical processing of the data. For more information on EPAPS, see http://www.aip.org/pubservs/epaps.html.
22. T. Baglin, Br. J. Haematol. 0007-1048 130, 653 (2005). 10.1111/j.1365-2141.2005.05612.x
23. D. Gailani and T. Renń, J. Thromb. Haemost. 5, 1106 (2007). 1538-7933 10.1111/j.1538-7836.2007.02446.x
24. N. Blow, Nat. Methods 1548-7091 4, 665 (2007). 10.1038/nmeth0807-665
25. M. Nguyen, Z. Wu, J. Micromech. Microeng. 0960-1317 10.1088/0960-1317/15/ 2/R01 15, R1 (2004).
26. K. Lo and S. L. Diamond, Thromb. Haemostasis 0340-6245 92, 874 (2004).