The evolutionarily conserved residue A653 plays a key role in HERG channel closing

Journal of Physiology

Volumn 587, Issue 11, 2009, Pages 2555-2566

  Stepanovic, Svetlana Z ^a   Potet, Franck ^a   Petersen, Christina I ^a   Smith, Jarrod A ^a   Meiler, Jens ^a   Balser, Jeffrey R ^a   Kupershmidt, Sabina ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYSTEINE; DOFETILIDE; GLYCINE; ISOLEUCINE; PHENYLALANINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL HERG; SERINE; THREONINE; TYROSINE; VALINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARDIOSELECTIVITY; CHANNEL GATING; CHO CELL; CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; ENZYME INACTIVATION; FEMALE; GENETIC CONSERVATION; HYPERPOLARIZATION; MEMBRANE POTENTIAL; MUTAGENESIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; CELL MEMBRANE STEADY POTENTIAL; CHANNEL CLOSING; DEACTIVATION TIME CONSTANT; MEMBRANE CURRENT; MOLECULAR MODEL; REVERSAL POTENTIAL; VOLTAGE CLAMP TECHNIQUE;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; COMPUTER SIMULATION; CONSERVED SEQUENCE; CRICETINAE; CRICETULUS; ETHER-A-GO-GO POTASSIUM CHANNELS; EVOLUTION, MOLECULAR; HUMANS; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; PHENETHYLAMINES; POTASSIUM CHANNEL BLOCKERS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TRANSFECTION; XENOPUS LAEVIS;

EID: 66549125616     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.166694     Document Type: Article

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