Thyroid dysfunction in patients with chronic hepatitis C: Virus- or therapy-related?

Journal of Gastroenterology and Hepatology (Australia)

Volumn 24, Issue 6, 2009, Pages 1024-1029

  Vezali, Elena ^a,b   Elefsiniotis, Ioannis ^a   Mihas, Constantinos ^a   Konstantinou, Evangelos ^a   Saroglou, George ^a  

^a University Department of Internal Medicine Hepatology Unit Elena Venizelou Hospital ^*  (Greece)

^b HELENA VENIZELOU HOSPITAL   (Greece)

Author keywords

Autoimmunity; Hepatitis C; Interferon; Ribavirin; Thyroid

Indexed keywords

HORMONE; LIOTRIX; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN;

ADULT; ANTIVIRAL THERAPY; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL FEATURE; CONTROLLED STUDY; CRYOGLOBULINEMIA; DISEASE EXACERBATION; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HEPATITIS C; HEPATITIS C VIRUS; HORMONE SUBSTITUTION; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; IDIOPATHIC THROMBOCYTOPENIC PURPURA; INCIDENCE; LICHEN PLANUS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PARAMETER; PRIORITY JOURNAL; PSORIASIS; RHEUMATOID ARTHRITIS; THYROID FUNCTION; TREATMENT WITHDRAWAL;

ADULT; ANTIVIRAL AGENTS; CHI-SQUARE DISTRIBUTION; DRUG THERAPY, COMBINATION; FEMALE; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2A; LOGISTIC MODELS; MALE; POLYETHYLENE GLYCOLS; RIBAVIRIN; RNA, VIRAL; THYROID DISEASES; THYROID FUNCTION TESTS;

EID: 66549120747     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2009.05812.x     Document Type: Article

References (35)

1. Zignego AL, Craxì A. Extrahepatic manifestations of hepatitis C virus infection. Clin. Liver Dis. 2008 12 : 611 36.
2. Antonelli A, Ferri C, Ferrari SM, Colaci M, Fallahi P. Immunopathogenesis of HCV related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia. Autoimmun. Rev. 2008 8 : 18 23.
3. Huang MJ, Tsai SL, Huang BY, Sheen IS, Yeh CT, Liaw YF. Prevalence and significance of thyroid antibodies in patients with chronic hepatitis C virus infection: a prospective controlled study. Clin. Endocrinol. (Oxf.) 1999 50 : 503 9.
4. Antonelli A, Ferri C, Pampana A et al. Thyroid disorders in chronic hepatitis C. Am. J. Med. 2004 117 : 10 13. (Pubitemid 38798015)
5. Antonelli A, Ferri C, Fallahi P et al. Thyroid cancer in HCV-related chronic hepatitis patients: a case-control study. Thyroid 2006 17 : 447 51.
6. Mc Hutchison JG, Gordon SC, Schiff ER et al. Interferon alpha-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N. Engl. J. Med. 1998 339 : 1485 92.
7. Lai MY, Kao JH, Yang PM et al. Long-term efficacy of ribavirin plus interferon alpha in the treatment of chronic hepatitis C. Gastroenterology 1996 111 : 1307 12.
8. NIH Consensus Statement on Management of Hepatitis C: 2002. NIH Consens State Sci Statements 2002 19 : 1 46.
9. Hadziyannis SJ, Sette H Jr., Morgan TR et al. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann. Intern. Med. 2004 140 : 346 55.
10. Manns MP, McHutchison JG, Gordon SC et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001 358 : 958 65.
11. Mandac JC, Chaudhry S, Sherman KE, Tomer Y. The clinical and physiological spectrum of interferon-alpha induced thyroiditis: toward a new classification. Hepatology 2006 43 : 661 72.
12. Kee KM, Lee CM, Wang JH et al. Thyroid dysfunction in patients with chronic hepatitis C receiving a combined therapy of interferon and ribavirin: incidence, associated factors and prognosis. J. Gastroenterol. Hepatol. 2005 21 : 319 26.
13. Ward DL, Bing-You RG. Autoimmune thyroid dysfunction induced by interferon-alpha treatment for chronic hepatitis C: screening and monitoring recommendations. Endocr. Pract. 2001 7 : 52 8.
14. Tomer Y, Blackard JT, Akeno N. Interferon alpha treatment and thyroid dysfunction. Endocrinol. Metab. Clin. North Am. 2007 36 : 1051 66.
15. Dalgard O, Bjøro K, Hellum K et al. Thyroid dysfunction during treatment of chronic hepatitis C with interferon alpha: no association with either interferon dosage or efficacy of therapy. J. Intern. Med. 2002 251 : 400 6.
16. Carella C, Mazziotti G, Amato G, Braverman EL, Roti E. Interferon-α-related thyroid disease: pathophysiological, epidemiological and clinical aspects. J. Clin. Endocrinol. Metab. 2004 89 : 3656 61.
17. Prummel MF, Laurberg P. Interferon-alpha and autoimmune thyroid disease. Thyroid 2003 13 : 547 51.
18. Carella C, Mazziotti G, Morisco F et al. The addition of ribavirin to interferon-α therapy in patients with hepatitis C virus-related chronic hepatitis does not modify the thyroid autoantibody pattern but increases the risk of developing hypothyroidism. Eur. J. Endocrinol. 2002 146 : 743 9.
19. Flynn RW, MacDonald TM, Morris AD, Jung RT, Leese GP. The thyroid epidemiology, audit, and research study: thyroid dysfunction in the general population. J. Clin. Endocrinol. Metab. 2004 89 : 3879 84.
20. Leese GP, Flynn RV, Jung RT, Macdonald TM, Murphy MJ, Morris AD. Increasing prevalence and incidence of thyroid disease in Tayside, Scotland: the Thyroid Epidemiology Audit and Research Study (TEARS). Clin. Endocrinol. (Oxf.) 2008 68 : 311 16.
21. Loviselli A, Oppo A, Velluzzi F et al. Independent expression of serological markers of thyroid autoimmunity and hepatitis virus C infection in the general population: results of a community-based study in north-western Sardinia. J. Endocrinol. Invest. 1999 22 : 660 5.
22. Floreani A, Betterle C, Carderi I et al. Arsita-one Research Group. Is hepatitis C virus is a risk factor for thyroid autoimmunity? J. Viral Hepat. 2005 13 : 272 7.
23. Marazuela M, García-Buey L, González-Fernández B et al. Thyroid autoimmune disorders in patients with chronic hepatitis C before and during interferon-alpha therapy. Clin. Endocrinol. (Oxf.) 1996 44 : 635 42.
24. Barrett S, Goh J, Coughlan B et al. The natural course of hepatitis C virus infection after 22 years in a unique homogenous cohort: spontaneous viral clearance and chronic HCV infection. Gut 2001 49 : 423 30.
25. Okanoue T, Sakamoto S, Itoh Y et al. Side effects of high dose interferon therapy for chronic hepatitis C. J. Hepatol. 1996 25 : 283 91.
26. Hsieh MC, Yu ML, Chuang WL et al. Virologic factors related to interferon-alpha-induced thyroid dysfunction in patients with chronic hepatitis C. Eur. J. Endocrinol. 2000 142 : 431 7.
27. Deutsch M, Dourakis S, Manesis EK et al. Thyroid abnormalities in chronic viral hepatitis and their relationship to interferon alfa therapy. Hepatology 1997 26 : 206 10.
28. Bini EJ, Mehandru S. Incidence of thyroid dysfunction during interferon alfa-2b and ribavirin therapy in men with chronic hepatitis C. Arch. Intern. Med. 2004 164 : 2371 6.
29. Friedrich-Rust M, Theobald J, Zeuzem S, Bojunga J. Thyroid function and changes in ultrasound morphology during antiviral therapy with pegylated interferon and ribavirin in patients with chronic hepatitis C. J. Viral Hepat. 2008 Oct 17 [Epub ahead of print HA, Attia JR, Jones TL, Batey RG. Pegylated interferon-alpha2beta in combination with ribavirin does not aggravate thyroid dysfunction in comparison to regular interferon-alpha2beta in a hepatitis C population: meta-analysis. J. Gastroenterol. Hepatol. 2006 22 : 472 6.
30. Tran A, Quaranta JF, Benzaken S et al. High prevalence of thyroid autoantibodies in a prospective series of patients with chronic hepatitis C before interferon therapy. Hepatology 1993 18 : 253 7.
31. Baudin E, Marcellin P, Pouteau M et al. Reversibility of thyroid dysfunction induced by recombinant alpha interferon in chronic hepatitis C. Clin. Endocrinol. (Oxf.) 1993 39 : 657 61.
32. Imagawa A, Itoh N, Hanafusa T et al. Autoimmune endocrine disease induced by recombinant interferon therapy for chronic active type C hepatitis. J. Clin. Endocrinol. Metab. 1995 80 : 922 6.
33. Roti E, Minelli R, Giuberti T et al. Multiple changes in thyroid function in patients with chronic active HCV hepatitis treated with recombinant interferon Am. J. Med. 1996 101 : 482 7.
34. Koh LK, Greenspan FS, Yeo PP. Interferon-alpha induced thyroid dysfunction: three clinical presentations and a review of the literature. Thyroid 1997 7 : 891 6.
35. Huang JF, Chuang WL, Dai CY et al. The role of autoantibodies in the development of thyroid dysfunction in Taiwanese chronic hepatitis C patients with interferon-alpha and ribavirin combination therapy. J. Viral Hepat. 2005 13 : 396 401.