A case of cerebral gumma presenting as brain tumor in a human immunodeficiency virus (HIV)-negative patient

Yonsei Medical Journal

Volumn 50, Issue 2, 2009, Pages 284-288

  Lee, Chan Woo ^a   Lim, Mi Jin ^a   Son, Dongwook ^a   Lee, Jin Soo ^a   Cheong, Moon Hyun ^a   Park, In Shu ^a   Lim, Myoung Kwan ^a   Kim, Eunsil ^b   Ha, Yoon ^c  

^a Inha University School of Medicine   (South Korea)

^b Daesung General Hospital   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

Brain tumor; Cerebral gumma; Neurosyphilis; Sexually transmitted disease; Syphilis

Indexed keywords

PENICILLIN G;

ADULT; ARTICLE; BRAIN DISEASE; BRAIN GUMMA; BRAIN TUMOR; CASE REPORT; CEREBROSPINAL FLUID; COMPUTER ASSISTED TOMOGRAPHY; CRANIOTOMY; DIFFERENTIAL DIAGNOSIS; FEMALE; FOLLOW UP; HEADACHE; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN TISSUE; NEUROSYPHILIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PLASMA CELL; POSTOPERATIVE PERIOD; SPIROCHETE;

ADULT; BRAIN NEOPLASMS; FEMALE; HIV INFECTIONS; HUMANS; MAGNETIC RESONANCE IMAGING; NEUROSYPHILIS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 66549107791     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2009.50.2.284     Document Type: Article

References (19)

1. Hook EW 3rd, Marra CM. Acquired syphilis in adults. N Engl J Med 1992;326:1060-9.
2. Wolters EC. Treatment of neurosyphilis. Clin Neuropharmacol 1987;10:143-54.
3. Ances BM, Danish SF, Kolson DL, Judy KD, Liebeskind DS. Cerebral gumma mimicking glioblastoma multiforme. Neurocrit Care 2005; 2:300-2.
4. Pall HS, Williams AC, Stockley RA. Intracranial gumma presenting as a cerebral tumour. J R Soc Med 1988;81:603-4.
5. Mitka M. US effort to eliminate syphilis moving forward. JAMA 2000;283:1555-6.
6. Hopkins RS, Jajosky RA, Hall PA, Adams DA, Connor FJ, Sharp P, et al. Summary of notifiable diseases--United States, 2003. MMWR Morb Mortal Wkly Rep 2005;52:1-85.
7. Doherty L, Fenton KA, Jones J, Paine TC, Higgins SP, Williams D, et al. Syphilis: old problem, new strategy. BMJ 2002;325:153-6.
8. Jang HC, Cho JH, Park WB, Lee KD, Lee CS, Kim HB, et al. Outbreak of primary and secondary syphilis among HIV sero-positive patients in Korea. Infect Chemother 2004;36:366-72.
9. Johns DR, Tierney M, Felsenstein D. Alteration in the natural history of neurosyphilis by concurrent infection with the human immuno deficiency virus. N Engl J Med 1987;316:1569-72.
10. Clark EG, Danbolt N. The Oslo study of the natural history of untreated syphilis; an epidemiologic investigation based on a restudy of the Boeck-Bruusgaard material; a review and appraisal. J Chronic Dis 1955;2:311-44.
11. Scheck DN, Hook EW 3rd. Neurosyphilis. Infect Dis Clin North Am 1994;8:769-95.
12. Merritt HH, Adams RD, Solomon HC. Neurosyphilis. New York: Oxford University Press, 1946:62-6.
13. Berger JR, Waskin H, Pall L, Hensley G, Ihmedian I, Post MJ. Syphilitic cerebral gumma with HIV infection. Neurology 1992;42: 1282-7.
14. Horowitz HW, Valsamis MP, Wicher V, Abbruscato F, Larsen SA, Wormser GP, et al. Brief report: cerebral syphilitic gumma confirmed by the polymerase chain reaction in a man with human immunodeficiency virus infection. N Engl J Med 1994;331:1488-91.
15. Agrons GA, Han SS, Husson MA, Simeone F. MR imaging of cerebral gumma. AJNR Am J Neuroradiol 1991;12:80-1.
16. Vogl T, Dresel S, Lochmuller H, Bergman C, Reimers C, Lissner J. Third cranial nerve palsy caused by gummatous neurosyphilis: MR findings. AJNR Am J Neuroradiol 1993;14:1329-31.
17. Brightbill TC, Ihmeidan IH, Post MJ, Berger JR, Katz DA. Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings. AJNR Am J Neuroradiol 1995;16:703-11.
18. Cartes-Zumelzu FW, Stavrou I, Castillo M, Eisenhuber E, Knosp E, Thurnher MM. Diffusion-weighted imaging in the assessment of brain abscesses therapy. AJNR Am J Neuroradiol 2004;25:1310-7.
19. Suarez JI, Mlakar D, Snodgrass SM. Cerebral syphilitic gumma in an HIV-negative patient presenting as prolonged focal motor status epilepticus. N Engl J Med 1996;335:1159-60.