Intractable epilepsy: Expression of substance P in cortical dysplastic neurons

Pediatrics International

Volumn 51, Issue 3, 2009, Pages 418-421

  Sakagami, Masanori ^a   Takahashi, Yukihiro ^b   Hoshida, Tohru ^c   Mochizuki, Tohru ^d   Matsuoka, Hiroaki ^a   Naka, Hiroyuki ^a   Fujimiya, Mineko ^e   Yoshioka, Akira ^c  

^a Tenri Municipal Hospital   (Japan)

^b NARA MEDICAL UNIVERSITY HOSPITAL   (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

^d SHIZUOKA CANCER CENTER   (Japan)

^e SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Dysplastic neurons; Focal cortical dysplasia; Intractile epilepsy; Substance P

Indexed keywords

ANTIBODY; ANTICONVULSIVE AGENT; BIOLOGICAL MARKER; METENKEPHALIN[6 ARGININE 7 GLYCINE 8 LEUCINE]; NEUROPEPTIDE Y; NEUROTENSIN; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; BRAIN TISSUE; CASE REPORT; CHILD; CORTICAL DYSPLASIA; ELECTROCORTICOGRAPHY; FEMALE; HIPPOCAMPUS; HISTOLOGY; HUMAN; IMMUNOCHEMISTRY; IMMUNOREACTIVITY; INTRACTABLE EPILEPSY; NAUSEA; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCHOOL CHILD; SPEECH DISORDER; TEMPORAL CORTEX; TEMPORAL LOBECTOMY; VOMITING; WHITE MATTER;

CHILD; EPILEPSY, TEMPORAL LOBE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MALFORMATIONS OF CORTICAL DEVELOPMENT; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; SUBSTANCE P;

EID: 66549094046     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/j.1442-200X.2009.002828.x     Document Type: Article

References (10)

1. Mischel PS, Nguyen LP, Vinters HV. Cerebral cortical dysplasia associated with pediatric epilepsy. Review of neuropathologic features and proposal for a grading system. J. Neuropathol. Exp. Neurol. 1995 54 : 137 53.
2. Kuzniecky R, Garcia JH, Faught E, Morawetz RB. Cortical dysplasia in temporal lobe epilepsy: Magnetic resonance imaging correlations. Ann. Neurol. 1991 29 : 293 8.
3. Otsuka M, Yoshioka K. Neurotransmitter functions of mammalian tachykinins. Physiol. Rev. 1993 73 : 229 308. (Pubitemid 23119035)
4. Mikuni N, Babb TL, Ying Z et al. NMDA-receptors 1 and 2A/B coassembly increased in human epileptic focal cortical dysplasia. Epilepsia 1999 40 : 1683 7.
5. Wasterlain CG, Liu H, Mazarati AM et al. Self-sustaining status epilepticus: a condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators. Epilepsia 2000 41 : 134 43.
6. Kramer RE, Lüders H, Goldstick LP et al. Ictus emeticus: an electroclinical analysis. Neurology 1988 38 : 1048 52.
7. Schindler K, Wieser HG. Ictal vomiting in a left hemisphere language-dominant patient with left-sided temporal lobe epilepsy. Epilepsy Behav. 2006 8 : 323 7.
8. Panayiotopoulos CP. Panayiotopoulos Syndrome. John Libbey, Eastleigh, 2002.
9. Liu H, Brown JL, Jasmin L et al. Synaptic relationship between substance P and the substance P receptor: Light and electron microscopic characterization of the mismatch between neuropeptides and their receptors. Proc. Natl Acad. Sci. USA 1994 91 : 1009 13.
10. Diemunsch P, Grélot L. Potential of substance P antagonists as antiemetics. Drugs 2000 60 : 533 46.