Identification of cross-reactive epitopes on the conserved 47-kilodalton antigen of Orientia tsutsugamushi and human serine protease

Infection and Immunity

Volumn 77, Issue 6, 2009, Pages 2311-2319

  Chen, Hua Wei ^a,b   Zhang, Zhiwen ^a,b   Huber, Erin ^a,b   Chao, Chien Chung ^a   Wang, Hui ^a,b   Dasch, Gregory A ^c   Ching, Wei Mei ^a,b  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BACTERIAL ANTIGEN; EPITOPE; HIGH TEMPERATURE REQUIREMENT A PROTEIN; PROTEIN; SERINE PROTEINASE; TRYPSIN; UNCLASSIFIED DRUG; VACCINE; BACTERIUM ANTIBODY; HTRA1 PROTEIN, HUMAN;

ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; AUTOIMMUNITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CROSS REACTION; HUMAN; MAJOR CLINICAL STUDY; ORIENTIA TSUTSUGAMUSHI; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCRUB TYPHUS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SEROLOGY; ANIMAL; BLOOD; IMMUNOLOGY; MOUSE;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; CROSS REACTIONS; EPITOPES; HUMANS; MICE; ORIENTIA TSUTSUGAMUSHI; SERINE ENDOPEPTIDASES;

EID: 66549085096     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01298-08     Document Type: Article

References (26)

1. Aguilar, C., J. L. Ortega, and N. Caro. 2005. Autoimmune type antiphospholipid antibodies in a patient with Q fever. Haematologica 90:33-34.
2. Berlin, T., G. Zandman-Goddard, M. Blank, T. Matthias, S. Pfeiffer, I. Weis, E. Toubi, S. Singh, R. Asherson, A. Fraser, B. Gilburd, T. Sapir, Y. Levy, J. Lukac, B. Rozman, T. Kveder, and Y. Shoenfeld. 2007. Autoantibodies in nonautoimmune individuals during infections. 1108:584-593.
3. Bourgeois, A. L., J. G. Olson, R. C. Fang, J. Huang, C. L. Wang, L. Chow, D. Bechthold, D. T. Dennis, J. C. Coolbaugh, and E. Weiss. 1982. Humoral and cellular responses in scrub typhus patients reflecting primary infection and reinfection with Rickettsia tsutsugamushi. Am. J. Trop. Med. Hyg. 31:532-540.
4. Brown, G. W., D. M. Robinson, D. L. Huxsoll, T. S. Ng, K. J. Lim, and G. Sannasey. 1976. Scrub typhus: a common cause of illness in indigenous population. Trans. R. Soc. Trop. Med. Hyg. 70:444-448.
5. Brown, G. W., J. P. Saunders, S. Singh, D. L. Huxsoll, and A. Shirai. 1978. Single dose deoxycycline therapy for scrub typhus. Trans. R. Soc. Trop. Med. Hyg. 72:412-416.
6. Campanelli, D., P. A. Detmers, C. F. Nathan, and J. E. Gabay. 1990. Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties. J. Clin. Investig. 85:904-915.
7. Ching, W.-M., H. Wang, B. Jan, and G. A. Dasch. 1996. Identification and characterization of epitopes on the 120-kilodalton surface protein antigen of Rickettsia prowazekii with synthetic peptides. Infect. Immun. 64:1413-1419.
8. De Luca, A., M. De Falco, A. Severino, M. Campioni, D. Santini, F. Baldi, M. G. Paggi, and A. Baldi. 2003. Distribution of the serine protease HtrA1 in normal human tissues. J. Histochem. Cytochem. 51:1279-1284.
9. Dighiero, G., B. Guilbert, and S. Avrameas. 1982. Naturally occurring antibodies against nine common antigens in human sera. II. High incidence of monoclonal Ig exhibiting antibody activity against actin and tubulin and sharing antibody specificities with natural antibodies. J. Immunol. 128:2788-2792.
10. Geysen, H. M. 1985. Antigen-antibody interactions at the molecular level: adventures in peptide synthesis. Immunol. Today 6:364-369.
11. Geysen, H. M., S. J. Rodda, T. J. Mason, G. Tribbick, and P. G. Schoofs. 1987. Strategies for epitope analysis using peptide synthesis. J. Immunol. Methods 102:259-274. (Pubitemid 17139413)
12. Hanson, B. 1985. Identification and partial characterization of Rickettsia tsutsugamushi major protein immunogens. Infect. Immun. 50:603-609.
13. Harrus, S., T. Waner, H. Bark, F. Jongejan, and A. W. Cornelissen. 1999. Recent advances in determining the pathogenesis of canine ehrlichiosis. J. Clin. Microbiol. 37:2745-2749.
14. Kim, M. J., M. K. Kim, and J. S. Kang. 2006. An epitope shared by cellular cytokeratin and Orientia tsutsugamushi. Microb. Pathog. 41:125-132.
15. Nie, G., K. Hale, Y. Li, U. Manuelpillai, E. M. Wallace, and L. A. Salamonsen. 2006. Distict expression and localization of serine protease HtrA1 in human endometrium and first-trimester placenta. Dev. Dyn. 235:3448-3455.
16. Ohashi, N., A. Tamura, H. Sakurai, and T. Suto. 1988. Immunoblotting analysis of anti-rickettsial antibodies produced in patients of tsutsugamushi disease. Microbiol. Immunol. 32:1085-1092.
17. Oldstone, M. B. 1998. Molecular mimicry and immune-mediated diseases. FASEB J. 12:1255-1265. (Pubitemid 28475568)
18. Ordi-Ros, J., A. Selva-O'Callaghan, F. Monegal-Ferran, Y. Monasterio-Aspiri, C. Juste-Sanchez, and M. Vilardell-Tarres. 1994. Prevalence, significance, and specificity of antibodies to phospholipids in Q fever. Clin. Infect. Dis. 18:213-218.
19. Sotto, A., M. Berard, D. Bessis, M. Porneuf, J. Jourdan, and M. C. Boffa. 1995. Antiphospholipid antibody production during Mediterranean spotted fever. Autoimmunity 21:123-126. (Pubitemid 26011170)
20. Stover, C. K., D. P. Marana, J. M. Carter, B. A. Roe, E. Mardis, and E. V. Oaks. 1990. The 56-kilodalton major protein antigen of Rickettsia tsutsugamushi: molecular cloning and sequence analysis of the sta56 gene and precise identification of a strain-specific epitope. Infect. Immun. 58:2076-2084.
21. Studier, F. W., and B. A. Moffatt. 1986. Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J. Mol. Biol. 189:113-130.
22. Waner, T., S. Harrus, D. J. Weiss, H. Bark, and A. Keysary. 1995. Demonstration of serum antiplatelet antibodies in experimental acute canine monocytic ehrlichiosis. Vet. Immunol. Immunopathol. 48:177-182.
23. Waner, T., I. Leykin, M. Shinitsky, E. Sharabani, H. Buch, A. Keysary, H. Bark, and S. Harrus. 2000. Detection of platelet-bound antibodies in beagle dogs after artificial infection with Ehrlichia canis. Vet. Immunol. Immunopathol. 77:145-150.
24. Weddle, J. R., T. C. Chan, K. Thompson, H. Paxton, D. J. Kelly, G. Dasch, and D. Strickman. 1995. Effectiveness of a dot-blot immunoassay of anti-Rickettsia tsutsugamushi antibodies for serologic analysis of scrub typhus. Am. J. Trop. Med. Hyg. 53:43-46.
25. Wong, S. J., and J. A. Thomas. 1998. Cytoplasmic, nuclear, and platelet autoantibodies in human granulocytic ehrlichiosis patients. J. Clin. Microbiol. 36:1959-1963.
26. Wucherpfennig, K. W. 2001. Mechanisms for the induction of autoimmunity by infectious agents. J. Clin. Investig. 108:1097-1104.