Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis

Molecular Cancer Therapeutics

Volumn 8, Issue 3, 2009, Pages 509-520

  Shah, Girish V ^a   Muralidharan, Anbalagan ^a   Thomas, Shibu ^a   Gokulgandhi, Mitan ^a   Mudit, Mudit ^a   Khanfar, Mohammad ^a   El Sayed, Khalid ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN; HYDANTOIN DERIVATIVE; PHENYL METHYLENE HYDANTOIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CANCER SCREENING; CELL ADHESION; CONTROLLED STUDY; CYTOTOXICITY; EXPERIMENTAL MOUSE; MALE; METASTASIS; MICROMETASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE TUMOR; TUMOR GROWTH; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CLASSIFICATION; DRUG EFFECT; DRUG SCREENING; HUMAN; ISOLATION AND PURIFICATION; MOLECULAR LIBRARY; NUDE MOUSE; PATHOLOGY; TRANSGENIC MOUSE; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL ADHESION; CELL PROLIFERATION; HUMANS; HYDANTOINS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICE, TRANSGENIC; NEOPLASM METASTASIS; PROSTATIC NEOPLASMS; SMALL MOLECULE LIBRARIES; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 66449120262     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0693     Document Type: Article

References (50)

1. Presti JC, Jr. Prostate cancer: assessment of risk using digital rectal examination, tumor grade, prostate-specific antigen, and systematic biopsy. Radiol Clin North Am 2000;38:49-58.
2. Thompson IM, Pauler DK, Goodman PJ, et al. Prevalence of prostate cancer among men with a prostate-specific antigen level ≤4.0 ng per milliliter. N Engl J Med 2004;350:2239-2246 (Pubitemid 38669206)
3. Jongsma J, Oomen MH, Noordzij MA, et al. Different profiles of neuroendocrine cell differentiation evolve in the PC-310 human prostate cancer model during long-term androgen deprivation. Prostate 2002;50:203-215 (Pubitemid 34184659)
4. Furuya Y, Akakura K, Akimoto S, Inomiya H, Ito H. Pattern of progression and survival in hormonally treated metastatic prostate cancer. Int J Urol 1999;6:240-244 (Pubitemid 29233808)
5. Segawa N, Mori I, Utsunomiya H, et al. Prognostic significance of neuroendocrine differentiation, proliferation activity, and androgen receptor expression in prostate cancer. Pathol Int 2001;51:452-459 (Pubitemid 32646211)
6. Cox ME, Deeble PD, Lakhani S, Parsons SJ. Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible: implications for prostate cancer progression. Cancer Res 1999;59:3821-3830 (Pubitemid 29381892)
7. Perez-Stable C, Altman NH, Mehta PP, Deftos LJ, Roos BA. Prostate cancer progression, metastasis, and gene expression in transgenic mice. Cancer Res 1997;57:900-906 (Pubitemid 27098015)
8. Chien J, Ren Y, QingWangY, et al. Calcitonin is a prostate epithelium-derived growth stimulatory peptide. Mol Cell Endocrinol 2001;181:69-79. (Pubitemid 32703750)
9. Thomas S, Chigurupati S, Anbalagan M, Shah G. Calcitonin increases tumorigenicity of prostate cancer cells: evidence for the role of protein kinase A and urokinase-type plasminogen receptor. Mol Endocrinol 2006;20:1894-1911 (Pubitemid 44148092)
10. Thomas S, Muralidharan A, Shah GV. Knock-down of calcitonin receptor expression induces apoptosis and growth arrest of prostate cancer cells. Int J Oncol 2007;31:1425-1437
11. Sabbisetti VS, Chirugupati S, Thomas S, et al. Calcitonin increases invasiveness of prostate cancer cells: role for cyclic AMP-dependent protein kinase A in calcitonin action. Int J Cancer 2005;117:551-560 (Pubitemid 41504542)
12. 2+ transients. Endocrinology 1994;134:596-602.
13. Ritchie CK, Thomas KG, Andrews LR, Tindall DJ, Fitzpatrick LA. Effects of the calciotrophic peptides calcitonin and parathyroid hormone on prostate cancer growth and chemotaxis. Prostate 1997;30:183-187
14. Nagakawa O, Ogasawara M, Fujii H, et al. Effect of prostatic neuropeptides on invasion and migration of PC-3 prostate cancer cells. Cancer Lett 1998;133:27-33. (Pubitemid 29069108)
15. Shah GV, Shibu T, Anbalagan M, et al. Calcitonin promotes in vivo metastasis of prostate cancer cells by altering cell signaling, adhesion, and inflammatory pathways. Endocrine Related Cancer 2008;15:1-15.
16. Shah GV, Anbalagan M, Gokulgandhi M, Soan K, Thomas S. Cadherin switching and activation of β-catenin signaling underlie proinvasive actions of calcitonin-calcitonin receptor axis in prostate cancer. J Biol Chem 2009;284:1018-1030
17. 2PBneo to the LPB-Tag model of prostate cancer. Lab Invest 2006;86:1074-1088
18. Yang M, Baranov E, Wang JW, et al. Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model. Proc Natl Acad Sci USA 2002;99:3824-3829 (Pubitemid 34252190)
19. Stephenson RA, Dinney CP, Gohji K, Ordonez NG, Killion JJ, Fidler IJ. Metastatic model for human prostate cancer using orthotopic implantation in nude mice. J Natl Cancer Inst 1992;84:951-957
20. SαQL)-mediated signaling increases invasiveness and tumorigenicity of PC-3M prostate cancer cells. Oncogene 1999;18:3376-3382
21. Heuser M, Ringert RH, Zoeller G, Hemmerlein B. Dynamic assessment of angiogenesis in renal cell carcinoma spheroids by intravital microscopy. J Urol 2003;169:1267-1270 (Pubitemid 36323764)
22. Hoevel T, Macek R, Swisshelm K, Kubbies M. Reexpression of the TJ protein CLDN1 induces apoptosis in breast tumor spheroids. Int J Cancer 2004;108:374-383 (Pubitemid 37549602)
23. Thomas S, Chiriva-Internati M, Shah GV. Calcitonin receptor-stimulated migration of prostate cancer cells is mediated by urokinase receptor-integrin signaling. Clin Exp Metastasis 2007;24:363-377 (Pubitemid 47134743)
24. Jankowski JA, Bruton R, Shepherd N, Sanders DS. Cadherin and catenin biology represent a global mechanism for epithelial cancer progression. Mol Pathol 1997;50:289-290 (Pubitemid 28057237)
25. Anderson JM, Van Itallie CM. Tight junctions and themolecular basis for regulation of paracellular permeability. Am J Physiol 1995;269:G467-75.
26. Denker BM, Nigam SK. Molecular structure and assembly of the tight junction. Am J Physiol 1998;274:F1-9. (Pubitemid 28133967)
27. Sakakibara A, Furuse M, Saitou M, Ando-Akatsuka Y, Tsukita S. Possible involvement of phosphorylation of occludin in tight junction formation. J Cell Biol 1997;137:1393-1401 (Pubitemid 27265950)
28. Sα) in proliferation of PC-3M prostate cancer cells. Int J Cancer 2001;91:46-54.
29. Fornaro M, Manes T, Languino LR. Integrins and prostate cancer metastases. Cancer Metastasis Rev 2001;20:321-331
30. 3 modulates bone metastatic growth and tissue remodeling. Oncogene 2007;26:6238-6243
31. 3 in prostate cancer progression. Neoplasia 2002;4:191-194
32. 5 and their ligands in the tumor cell and endothelial cell adhesion. Eur J Cancer Prev 2007;16:517-527
33. Shao TC, Li HL, Kasper S, Matusik R, Ittmann M, Cunningham GR. Comparison of the growth-promoting effects of testosterone and 7-α-methyl-19-nor- testosterone (MENT) on the prostate and levator ani muscle of LPB-tagtransg enic mice. Prostate 2006;66:369-376 (Pubitemid 43346947)
34. Hurd TW, Gao L, Roh MH, Macara IG, Margolis B. Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Nat Cell Biol 2003;5:137-142 (Pubitemid 36210848)
35. Kohler K, Zahraoui A. Tight junction: a co-ordinator of cell signalling and membrane trafficking. Biol Cell 2005;97:659-665 (Pubitemid 41079038)
36. Thiery JP, Boyer B, Tucker G, Gavrilovic J, Valles AM. Adhesion mechanisms in embryogenesis and in cancer invasion and metastasis. Ciba Found Symp 1988;141:48-74.
37. Szafranski P, Goode S. Basolateral junctions are sufficient to suppress epithelial invasion during Drosophila oogenesis. Dev Dyn 2007;236:364-373 (Pubitemid 46233280)
38. Keiper T, Santoso S, Nawroth PP, Orlova V, Chavakis T. The role of junctional adhesion molecules in cell-cell interactions. Histol Histopathol 2005;20:197-203. (Pubitemid 40028998)
39. Martin TA, Watkins G, Mansel RE, JiangWG. Loss of tight junction plaque molecules in breast cancer tissues is associated with a poor prognosis in patients with breast cancer. Eur J Cancer 2004;40:2717-2725 (Pubitemid 39574723)
40. Tyagi N, Sharma S, Tyagi SP, et al. A histomorphologic and ultrastructural study of the malignant tumours of the renal pelvis. J Postgrad Med 1993;39:197-201.
41. Witkowski CM, Rabinovitz I, Nagle RB, Affinito KS, Cress AE. Characterization of integrin subunits, cellular adhesion, and tumorgenicity of four human prostate cell lines. J Cancer Res Clin Oncol 1993;119:637-644 (Pubitemid 23238145)
42. Hirohashi S, Kanai Y. Cell adhesion system and human cancer morphogenesis. Cancer Sci 2003;94:575-581 (Pubitemid 36975010)
43. Cohen MB, GrieblingTL, Ahaghotu CA, Rokhlin OW, Ross JS. Cellular adhesion molecules in urologic malignancies. Am J Clin Pathol 1997;107:56-63. (Pubitemid 27104637)
44. Waltregny D, Castronovo V. Recent advances in prostate cancer metastasis. Tumori 1996;82:193-204. (Pubitemid 26253706)
45. Albini A. Tumor microenvironment, a dangerous society leading to cancer metastasis. From mechanisms to therapy and prevention. Cancer Metastasis Rev 2008;27:3-4.
46. Kasper S. Survey of genetically engineered mouse models for prostate cancer: analyzingthe molecular basis of prostate cancer development, progression, and metastasis. J Cell Biochem 2005;94:279-297 (Pubitemid 41420307)
47. Thenmozhiyal JC, Wong PT, Chui WK. Anticonvulsant activity of phenylmethylenehydantoins: a structure-activity relationship study. J Med Chem 2004;47:1527-1535 (Pubitemid 38327476)
48. Naohiro I, Tadayoshi S, Ikuo K, Katsuji Y, Yutaka A, Toshiaki Y. Diisopropylbenzylidene-substituted heterocycles. Jpn Kokai Tokkyo Koho JP 62029570; CAN106:213918. 1987.
49. Wattanadilok R, Sawangwong P, Rodrigues C, et al. Antifungal activity evaluation of the constituents of Haliclona baeri and Haliclona cymaeformis, collected from the Gulf of Thailand. Mar Drugs 2007;5:40-51. (Pubitemid 46998589)
50. Balda MS, Matter K. Transmembrane proteins of tight junctions. Semin Cell Dev Biol 2000;11:281-289 (Pubitemid 32066135)