Neopterin and cardiovascular disease: Growing evidence for a role in patient risk stratification

Clinical Chemistry

Volumn 55, Issue 6, 2009, Pages 1056-1057

  Avanzas, Pablo ^a   Arroyo Espliguero, Ramón ^b   Kaski, Juan Carlos ^c  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^b HOSPITAL UNIVERSITARIO DE GUADALAJARA   (Spain)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; NEOPTERIN;

ACUTE CORONARY SYNDROME; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; DISEASE COURSE; EDITORIAL; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; INFLAMMATION; MACROPHAGE; MORTALITY; PHENOTYPE; PROGNOSIS; RISK ASSESSMENT; STABLE ANGINA PECTORIS;

CARDIOVASCULAR DISEASES; HUMANS; NEOPTERIN; RISK ASSESSMENT;

EID: 66449115492     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2009.127084     Document Type: Editorial

References (16)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (Lond) 1993;362:801-809 (Pubitemid 23132154)
2. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO III, Criqui M, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice. A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003;107:499-511.
3. Zebrack JS, Muhlestein JB, Horne BD, Anderson JL. C-reactive protein and angiographic coronary artery disease: independent and additive predictors of risk in subjects with angina. J Am Coll Cardiol 2002;39:632-637 (Pubitemid 34158159)
4. Arroyo-Espliguero R, Avanzas P, Cosin-Sales J, Aldama G, Pizzi C, Kaski JC. C-reactive protein elevation and disease activity in patients with coronary artery disease. Eur Heart J 2004;25:401-408 (Pubitemid 38391522)
5. Avanzas P, Arroyo-Espliguero R, Cosin-Sales J, Quiles J, Zouridakis E, Kaski JC. Prognostic value of neopterin levels in treated patients with hypertension and chest pain but without obstructive coronary artery disease. Am J Cardiol 2004;93:627-629 (Pubitemid 38293075)
6. Avanzas P, Arroyo-Espliguero R, Quiles J, Roy D, Kaski JC. Elevated serum neopterin predicts future adverse cardiac events in patients with chronic stable angina pectoris. Eur Heart J 2005;26:457-463 (Pubitemid 40314761)
7. Kaski JC, Consuegra-Sanchez L, Fernandez-Berges DJ, Cruz-Fernandez JM, Garcia-Moll X, Marrugat J, et al. Elevated serum neopterin levels and adverse cardiac events at 6 months follow-up in Mediterranean patients with non- ST-segment elevation acute coronary syndrome. Atherosclerosis [Epub ahead of print 2008 Mar 10].
8. Garcia-Moll X, Cole D, Zouridakis E, Kaski JC. Increased serum neopterin: a marker of coronary artery disease activity in women. Heart 2000;83:346-350 (Pubitemid 30313342)
9. van Haelst PL, Liem A, van Boven AJ, Veeger NJ, van Veldhuisen DJ, Tervaert JW, et al. Usefulness of elevated neopterin and C-reactive protein levels in predicting cardiovascular events in patients with non-Q-wave myocardial infarction. Am J Cardiol 2003;92:1201-1203 (Pubitemid 37377833)
10. Ray KK, Morrow DA, Sabatine MS, Shui A, Rifai N, Cannon CP, et al. Long-term prognostic value of neopterin: a novel marker of monocyte activation in patients with acute coronary syndrome. Circulation 2007;115:3071-3078 (Pubitemid 46956496)
11. Grammer TB, Fuchs D, Boehm BO, Winkelmann BR, Maerz W. Neopterin as a predictor of total and cardiovascular mortality in individuals undergoing angiography in the Ludwigshafen Risk and Cardiovascular Health Study. Clin Chem 2009;55:1135-1146
12. Avanzas P, Arroyo-Espliguero R, Cosín-Sales J, Aldama G, Pizzi C, Quiles J, et al. Markers of inflammation and multiple complex stenoses (pancoronary plaque vulnerability) in patients with non-ST segment elevation acute coronary syndromes. Heart 2004;90:847-852 (Pubitemid 39022574)
13. Zouridakis E, Avanzas P, Arroyo-Espliguero R, Fredericks S, Kaski JC. Markers of inflammation and rapid coronary artery disease progression in patients with stable angina pectoris. Circulation 2004;110:1747-1753 (Pubitemid 39299216)
14. Adachi T, Naruko T, Itoh A, Komatsu R, Abe Y, Shirai N, et al. Neopterin is associated with plaque inflammation and destabilisation in human coronary atherosclerotic lesions. Heart 2007;93:153-741. (Pubitemid 350205545)
15. Kaski JC, Avanzas P, Arroyo-Espliguero R. Neopterin: a forgotten biomarker. J Am Coll Cardiol 2003;42:1140-1146
16. Kaski JC, Avanzas P, Arroyo-Espliguero R. Neopterin: still a forgotten biomarker. Clin Chem 2005;51:1902-1903