Diagnosis, management and prevalence estimation of gonorrhoea: Influences of Aptima Combo 2 assay with alternative target confirmation

International Journal of STD and AIDS

Volumn 20, Issue 5, 2009, Pages 315-319

  Mahto, M ^a   Zia, S ^a   Ritchie, D ^b   Mallinson, H ^c  

^a Assura Health and Wellness Centre   (United Kingdom)

^b MACCLESFIELD DISTRICT GENERAL HOSPITAL   (United Kingdom)

^c ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

Aptima combo 2; Confirmation; Culture; Dual testing; Gonorrhoea; Management; Nucleic acid amplification tests; Prevalence

Indexed keywords

ADOLESCENT; ADULT; AGED; APTIMA COMBO ASSAY; ARTICLE; ASSAY; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; FEMALE; GONORRHEA; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICINE; MICROSCOPY; NEISSERIA GONORRHOEAE; NUCLEIC ACID AMPLIFICATION; OUTPATIENT DEPARTMENT; PREVALENCE; PRIORITY JOURNAL; SEX RATIO; UROGENITAL SYSTEM;

ADOLESCENT; ADULT; AGED; ANTI-INFECTIVE AGENTS; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; FEMALE; GONORRHEA; GREAT BRITAIN; HOSPITALS, COMMUNITY; HOSPITALS, SPECIAL; HUMANS; MALE; MIDDLE AGED; NEISSERIA GONORRHOEAE; PREVALENCE; REAGENT KITS, DIAGNOSTIC; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 66349106049     PISSN: 09564624     EISSN: None     Source Type: Journal    
DOI: 10.1258/ijsa.2008.008410     Document Type: Article

References (27)

1. 1 Whiley DM, Tapsall JW, Sloots TP. Nucleic acid amplification testing for Neisseria gonorrhoeae - an ongoing challenge. J Mol Diag 2006;8(1):3-15 (Pubitemid 43257429)
2. 2 Van Dyck E, Leven M, Pattyn S, et al. Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by enzyme immunoassay, culture, and three nucleic acid amplification tests. J Clin Microbiol 2001;39:1751-1756 (Pubitemid 32417015)
3. 3 Stanley B, Todd A. Testing for Neisseria gonorrhoea by nucleic amplification testing of chlamydia samples using Roche Cobas Amplicor in a rural area in the north of England does not find more gonorrhoeae in primary care. Sex Transm Infect 2005;81:518 (Pubitemid 41811338)
4. 4 Diemert DJ, Libman MD, Lebel P. Confirmation by 16SrRNA PCR of the Cobas Amplicor CT/NG test for diagnosis of Neisseria gonorrhoeae infection in a low prevalence population. J Clin Microbiol 2002;40:4056-4059 (Pubitemid 35285789)
5. 5 Katz A, Effer PV, Ohye RG, et al. False positive gonorrhoea test results with a nucleic acid amplification test: the impact of low prevalence on positive predictive value. Clin Infect Dis 2004;38:814-819 (Pubitemid 38387228)
6. 6 Palmer HM, Mallinson H, Wood RL, et al. Evaluation of specificities of five DNA amplification methods for the detection of Neisseria gonorrhoeae. J Clin Microbiol 2003;41(2):835-837 (Pubitemid 36184209)
7. Moncada J, Donegan E, Schachter J. Evaluation of CDC - recommended approaches for confirmatory testing of positive Neisseria gonorrhoeae nucleic acid amplification test results. J Clin Microbiol 2008;46:1614-1619
8. 8 LaMontagne DS, Fenton KA, Pimenta JM, et al. Using chlamydia positivity to estimate prevalence: evidence from the Chlamydia Screening Pilot in England. Int J STD AIDS 2005;16:323-327 (Pubitemid 40676413)
9. Scottish Guidelines for Molecular Testing for Neisseria gonorrhoeae. See [http://www.hps.scot.nhs.uk/training/presentations.aspx?id=167] (last accessed 25 February 2009)
10. 10 Cook RL, Hutchison SL, Ostergaard L, et al. Systematic review: noninvasive testing for Chlamydia trachomatis and Neisseria gonorrhoeae. Ann Intern Med 2005;142:914-925 (Pubitemid 40791807)
11. Barlow D. Commentary. Sex Transm Infect 2008;84:121
12. Johnson REC, Newhall WJ, Papp JR, et al. Screening tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections - 2002. MMWR Recomm Rep 2002;18:1-38
13. 13 Boyadzhyan B, Yashina T, Yatabe H, et al. Comparison of the Aptima CT and GC assays with the Aptima Combo 2 assay, the Abbott LCx assay, and direct-fluorescent antibody and culture assays for detection of Chlamydia trachomatis and Neisseria gonorrhoeae. J Clin Microbiol 2004;42:3089-3093 (Pubitemid 38938063)
14. 14 Golden MR, Hughes JP, Cles LE, et al. Positive predictive value of Gen-Probe APTIMA combo 2 testing for Neisseria gonorrhoeae in a population of women with low prevalence of N. gonorrhoeae infection. Clin Infect Dis 2004;39:1387-1390 (Pubitemid 39458527)
15. Moss S, Mallinson H. The contribution of Aptima Combo 2 assay to the diagnosis of gonorrhoea in genitourinary medicine setting. Int. J STD AIDS 2007;18:551-554
16. O'Mahony C, Fowkes AR, Worthen E, Mallinson H. Three years of using Aptima Combo 2(AC2) transcription-mediated amplification for gonorrhoea in a district hospital genitourinary medicine clinic show it to be superior to culture and has a specificity of almost 100%. Int J STD AIDS 2008; 19:67-69
17. 17 Lister NA, Tabrizi SN, Fairley CK, et al. Validation of Roche Cobas Amplicor assay for detection of Chlamydia trachomatis in rectal and pharyngeal specimens by an omp1 PCR assay. J Clin Microbiol 2004;42:239-241 (Pubitemid 38082726)
18. 18 Alexander S, Martin I, Ison C. Confirming the Chlamydia trachomatis status of referred rectal specimens. Sex Transm Infect 2007;83:327-329 (Pubitemid 47242514)
19. 19 Young H, Anderson J, Moyes A, McMillan A. Non-culture detection of rectal and pharyngeal gonorrhoea by the Gen-Probe PACE 2 assay. Genitourin Med 1997;73:50-62 (Pubitemid 27076090)
20. Alloba F, Allawattegama A, Jones C. Use of nucleic amplification tests for the detection of Neisseria gonorrhoeae: survey of genitourinary medicine clinics in England. Int J STD AIDS 2007;18:652-653
21. Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) Annual Report 2007. See [http://www.hpa.org.uk/web/HPAwebFile/HPAweb-C/ 1221117895841] (last accessed 25 February 2009)
22. 22 Ryan C, Kudesia G, McIntyre S, et al. BD ProbeTec ET assay for the diagnosis of gonorrhoea in a high risk population: a protocol for replacing traditional microscopy and culture techniques. Sex Transm Infect 2007;83:175-179 (Pubitemid 46999178)
23. 23 Lavell SJ, Jones KE, Mallinson H, et al. Finding, confirming, and managing gonorrhoea in a population screened for chlamydia using the Gen-Probe Aptima Combo 2 assay. Sex Transm Infect 2006;82:221-224 (Pubitemid 43901590)
24. Aghaizu AR, Atherton H, Mallinson H, et al. Prevalence of Neisseria gonorrhoea infection in young women in South London. See http://sti.bmi.com/cgi/ eletters/84/2/117 (last accessed 25 February 2009)
25. Rao G, Bacon L, Evans J, et al. Prevalence of Neisseria gonorrhoeae infections in young subjects attending community clinics in South London. Sex Transm Infect 2008;84:117-121
26. John G. Evans-Jones (6 February 2008). The KC60 and the future. E letter available at http://sti.bmj.com/cgi/eletters/83/6/433 (last accessed 25 February 2009)
27. Lavelle SJ, Mallinson H, Henning SJ, Webb A, Hughes S, Abbott M. Impact on Gonorrhoea case reports of concomitant testing in a chlamydia screening population. Sex Transm Infect 2007;83:593-594