Subclinical hypothyroidism after radioiodine exposure: Ukrainian-American cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident (1998-2000)

Environmental Health Perspectives

Volumn 117, Issue 5, 2009, Pages 745-750

  Ostroumova, Evgenia ^a   Brenner, Alina ^a   Oliynyk, Valery ^b   McConnell, Robert ^c   Robbins, Jacob ^d   Terekhova, Galina ^b   Zablotska, Lydia ^e   Likhtarev, Ilya ^f   Bouville, Andre ^a   Shpak, Viktor ^b   Markov, Valentin ^b   Masnyk, Ihor ^a   Ron, Elaíne ^a   Tronko, Mykola ^b   Hatch, Maureen ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b V P Komisarenko Institute of Endocrinology and Metabolism of the Ukraine Academy of Medical Sciences   (Ukraine)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e Academy of Medical Science ^*  (United States)

^f STATE INSTITUTION NATIONAL RESEARCH CENTER FOR RADIATION MEDICINE OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE   (Ukraine)

Author keywords

Chernobyl nuclear accident; Chornobyl; Dose response relationship; Hypothyroidism; Ionizing radiation

Indexed keywords

IODINE 131; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROXINE;

ADOLESCENT; ADULT; ARTICLE; CHERNOBYL ACCIDENT; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIATION DOSE; RADIATION EXPOSURE; RADIOACTIVITY; RISK FACTOR; SCHOOL CHILD; THYROID CANCER; THYROID DISEASE; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; UKRAINE; WESTERN HEMISPHERE;

ADOLESCENT; ADULT; AGE DISTRIBUTION; CHERNOBYL NUCLEAR ACCIDENT; CHILD; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPOTHYROIDISM; IODINE RADIOISOTOPES; MALE; SEX DISTRIBUTION; THYROID DISEASES; THYROID NEOPLASMS; YOUNG ADULT;

EID: 66349105885     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0800184     Document Type: Article

References (52)

1. Agate L, Mariotti S, Elisei R, Mossa P, Pacini F, Molinaro E, et al. 2008. Thyroid autoantibodies and thyroid function in subjects exposed to Chernobyl fallout during childhood: evidence for a transient radiation-induced elevation of serum thyroid antibodies without an increase in thyroid autoimmune disease. J Clin Endocrinol Metab 93:2729-2736.
2. Andersen S, Bruun NH, Pedersen KM, Laurberg P. 2003. Biologic variation is important for interpretation of thyroid function tests. Thyroid 13:1069-1078.
3. Åsvold BO, Bjoro T, Nilsen TI, Vatten LJ. 2007. Tobacco smoking and thyroid function: a population-based study. Arch Intern Med 167:1428-1432.
4. Belin RM, Astor BC, Powe NR, Ladenson PW. 2004. Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 89:6077-6086.
5. Bjøro T, Holmen J, Krüger Ø, Midthjell K, Hunstad K, Schreiner T, et al. 2000. Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trøndelag (HUNT). Eur J Endocrinol 143:639-647.
6. Brunn J, Block U, Ruf G, Bos I, Kunze WP, Scriba PC. 1981. Volumetric analysis of thyroid lobes by real-time ultrasound. Dtsch Med Wochenschr 106:1338-1340.
7. 131I in childhood. J Natl Cancer Inst 97:724-732.
8. Ceccarelli C, Bencivelli W, Vitti P, Grasso L, Pinchera A. 2005. Outcome of radioiodine-131 therapy in hyperfunctioning thyroid nodules: a 20 years' retrospective study. Clin Endocrinol (Oxf) 62:331-335.
9. Chiovato L, Fiore E, Vitti P, Rocchi R, Rago T, Dokic D, et al. 1998. Outcome of thyroid function in Graves' patients treated with radioiodine: role of thyroid-stimulating and thyroid-blocking antibodies and of radioiodine-induced thyroid damage. J Clin Endocrinol Metab 83:40-46.
10. Cooper DS. 2005. Treatment of thyrotoxicosis. In: Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text (Braverman LE, Utiger RD, eds). Philadelphia:Lippincott Williams & Wilkins, 665-694.
11. Davis S, Kopecky KJ, Hamilton TE, Onstad L, Hanford Thyroid Study Team. 2004. Thyroid neoplasia, autoimmune thyroiditis, and hypothyroidism in persons exposed to iodine 131 from the Hanford nuclear site. JAMA 292:2600-2613.
12. Eheman CR, Garbe P, Tuttle RM. 2003. Autoimmune thyroid disease associated with environmental thyroidal irradiation. Thyroid 13:453-464.
13. Flynn RW, MacDonald TM, Morris AD, Jung RT, Leese GP. 2004. The thyroid epidemiology, audit, and research study: thyroid dysfunction in the general population. J Clin Endocrinol Metab 89:3879-3884.
14. Goldsmith JR, Grossman CM, Morton WE, Nussbaum RH, Kordysh EA, Quastel MR, et al. 1999. Juvenile hypothyroidism among two populations exposed to radioiodine. Environ Health Perspect 107:303-308.
15. Hancock SL, McDougall IR, Constine LS. 1995. Thyroid abnormalities after therapeutic external radiation. Int J Radiat Oncol Biol Phys 31:1165-1170.
16. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. 2002. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87:489-499.
17. Hoogendoorn EH, Hermus AR, de Vegt F, Ross HA, Verbeek AL, Kiemeney LA, et al. 2006. Thyroid function and prevalence of anti-thyroperoxidase antibodies in a population with borderline sufficient iodine intake: influences of age and sex. Clin Chem 52:104-111.
18. Imaizumi M, Usa T, Tominaga T, Neriishi K, Akahoshi M, Nakashima E, et al. 2006. Radiation dose-response relationships for thyroid nodules and autoimmune thyroid diseases in Hiroshima and Nagasaki atomic bomb survivors 55-58 years after radiation exposure. JAMA 295:1011-1022.
19. Ivanov VK, Gorski AI, Tsyb AF, Maksioutov MA, Tumanov KA, Vlasov OK. 2006. Radiation-epidemiological studies of thyroid cancer incidence among children and adolescents in the Bryansk oblast of Russia after the Chernobyl accident (1991-2001 follow-up period). Radiat Environ Biophys 45:9-16.
20. Jacob P, Kenigsberg Y, Zvonova I, Goulko G, Buglova E, Heidenreich WF, et al. 1999. Childhood exposure due to the Chernobyl accident and thyroid cancer risk in contaminated areas of Belarus and Russia. Br J Cancer 80:1461-1469.
21. Jereczek-Fossa BA, Alterio D, Jassem J, Gibelli B, Tradati N, Orecchia R. 2004. Radiotherapy-induced thyroid disorders. Cancer Treat Rev 30:369-384.
22. Jorde R, Sundsfjord J. 2006. Serum TSH levels in smokers and non-smokers. The 5th Tromsø Study. Exp Clin Endocrinol Diabetes 114:343-347.
23. Kasatkina EP, Shilin DE, Rosenbloom AL, Pykov MI, Ibragimova GV, Sokolovskaya VN, et al. 1997. Effects of low level radiation from the Chernobyl accident in a population with iodine deficiency. Eur J Pediatr 156:916-920.
24. Knudsen N, Jørgensen T, Rasmussen S, Christiansen E, Perrild H. 1999. The prevalence of thyroid dysfunction in a population with borderline iodine deficiency. Clin Endocrinol (Oxf) 51:361-367.
25. Larsen PR, Conard RA, Knudsen KD, Robbins J, Wolff J, Rall JE, et al. 1982. Thyroid hypofunction after exposure to fallout from a hydrogen bomb explosion. JAMA 247:1571-1575.
26. Likhtarev I, Bouville A, Kovgan L, Luckyanov N, Voillequé P, Chepurny M. 2006. Questionnaire- and measurement-based individual thyroid doses in Ukraine resulting from the Chornobyl nuclear reactor accident. Radiat Res 166:271-286.
27. Likhtarev I, Minenko V, Khrouch V, Bouville A. 2003. Uncertainties in thyroid dose reconstruction after Chernobyl. Radiat Prot Dosimetry 105:601-608.
28. Likhtarov I, Kovgan L, Vavilov S, Chepurny M, Bouville A, Luckyanov N, et al. 2005. Post-Chornobyl thyroid cancers in Ukraine. Report 1: estimation of thyroid doses. Radiat Res 163:125-136.
29. Likhtarov I, Kovgan L, Vavilov S, Chepurny M, Ron E, Lubin J, et al. 2006. Post-Chornobyl thyroid cancers in Ukraine. Report 2: risk analysis. Radiat Res 166:375-386.
30. Lyon JL, Alder SC, Stone MB, Scholl A, Reading JC, Holubkov R, et al. 2006. Thyroid disease associated with exposure to the Nevada nuclear weapons test site radiation. Epidemiology 17:604-614.
31. Mallick B, Hoffman FO, Carroll RJ. 2002. Semiparametric regression modeling with mixtures of Berkson and classical error, with application to fallout from the Nevada test site. Biometrics 58:13-20.
32. Mariotti S, Martino E, Francesconi M, Ceccarelli C, Grasso L, Lippi F, et al. 1986. Serum thyroid autoantibodies as a risk factor for development hypothyroidism after radio-active iodine therapy for single thyroid "hot" nodule. Acta Endocrinol (Copenh) 113:500-507.
33. Marwaha RK, Tandon N, Desai A, Kanwar R, Grewal K, Aggarwal R, et al. 2008. Reference range of thyroid hormones in normal Indian school-age children. Clin Endocrinol (Oxf) 68:369-374.
34. Nagataki S, Shibata Y, Inoue S, Yokoyama N, Izumi M, Shimaoka K. 1994. Thyroid diseases among atomic bomb survivors in Nagasaki. JAMA 272:364-370.
35. O'Leary PC, Feddema PH, Michelangeli VP, Leedman PJ, Chew GT, Knuiman M, et al. 2006. Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study. Clin Endocrinol (Oxf) 64:97-104.
36. Pacini F, Vorontsova T, Molinaro E, Kuchinskaya E, Agate L, Shavrova E, et al. 1998. Prevalence of thyroid autoantibodies in children and adolescents from Belarus exposed to the Chernobyl radioactive fallout. Lancet 352:763-766.
37. Pedersen IB, Knudsen N, Jørgensen T, Perrild H, Ovesen L, Laurberg P. 2003. Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency. Clin Endocrinol (Oxf) 58:36-42.
38. Preston DL, Lubin JH, Pierce DA, McConney ME. 1993. Epicure. Seattle, WA:Hirosoft International Corporation.
39. Quastel MR, Goldsmith JR, Mirkin L, Poljak S, Barki Y, Levy J, Gorodischer R. 1997. Thyroid-stimulating hormone levels in children from Chernobyl. Environ Health Perspect 105:1497-1498.
40. Saiko AS, Goncharenko OE, Daniliuk VV, Panasyuk GD, Derzhtskaya NK, Cot VA, et al. 1997. Findings of the Chernobyl Sasakawa Health and Medical Cooperation Project: abnormal thyroid echogenity and autoimmune thyroid diseases around Chernobyl. In: Chernobyl: A Decade (Yamashita S, Shibata Y, eds). Amsterdam:Elsevier Science, 73-84.
41. Stezhko VA, Buglova EE, Danilova LI, Drozd VM, Krysenko NA, Lesnikova NR, et al. 2004. A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: objectives, design and methods. Radiat Res 161:481-492.
42. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, et al. 2004. Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 291:228-238.
43. Takahashi T, Fujimori K, Simon SL, Bechtner G, Edwards R, Trott KR. 1999. Thyroid nodules, thyroid function and dietary iodine in the Marshal Islands. Int J Epidemiol 28:742-749.
44. Tronko MD, Brenner AV, Olijnyk VA, Robbins J, Epstein OV, McConnell RJ, et al. 2006a. Autoimmune thyroiditis and exposure to iodine 131 in the Ukrainian cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: results from the first screening cycle (1998-2000). J Clin Endocrinol Metab 91:4344-4351.
45. Tronko MD, Howe GR, Bogdanova TI, Bouville AC, Epstein OV, Brill AB, et al. 2006b. A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: thyroid cancer in Ukraine detected during first screening. J Natl Cancer Inst 98:897-903.
46. Tronko M, Kravchenko V, Fink D, Hatch M, Turchin V, McConnell R, et al. 2005. Iodine excretion in regions of Ukraine affected by the Chornobyl accident: experience of the Ukrainian-American cohort study of thyroid cancer and other thyroid diseases. Thyroid 15:1291-1297.
47. United Nations Scientific Committee on the Effects of Atomic Radiation. 2000. Sources and Effects of Ionizing Radiation. New York:United Nations.
48. Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, et al. 1995. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf) 43:55-68.
49. Vermiglio F, Castagna MG, Volnova E, Lo Presti VP, Moleti M, Violi MA, et al. 1999. Post-Chernobyl increased prevalence of humoral thyroid autoimmunity in children and adolescents from a moderately iodine-deficient area in Russia. Thyroid 9:781-786.
50. 131I dose-dependent thyroid autoimmune disorders in children living around Chernobyl. Clin Immunol Immunopathol 84:251-259.
51. Zimmermann MB, Wegmüller R, Zeder C, Chaouki N, Torresani T. 2004. The effects of vitamin A deficiency and vitamin A supplementation on thyroid function in goitrous children. J Clin Endocrinol Metab 89:5441-5447.
52. Zurakowski D, Di Canzio J, Maizoub JA. 1999. Pediatric reference intervals for serum thyroxine, triiodothyronine, thyrotropin and free thyroxine. Clin Chem 45:1087-1091.