Synthesis of 11C-labeled 2-aminoethanol via a nitroaldol reaction using nitro[11C]methane

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 13, 2009, Pages 3439-3441

  Kato, Koichi ^a   Zhang, Ming Rong ^a   Minegishi, Katsuyuki ^a   Suzuki, Kazutoshi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

2 Aminoethanol; Nitro 11C methane; Positron emission tomography

Indexed keywords

CARBON 11; ETHANOLAMINE; ETHANOLAMINE C 11; FORMALDEHYDE; NICKEL CHLORIDE; NITROMETHANE; NITROMETHANE C 11; UNCLASSIFIED DRUG;

ACETALIZATION; ALDOL REACTION; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; HYDROGENATION; NITRATION; NITROALDOL REACTION; POSITRON EMISSION TOMOGRAPHY; REDUCTION;

CARBON ISOTOPES; ETHANOLAMINES; METHANE; NITROPARAFFINS; RADIOPHARMACEUTICALS; TIME FACTORS;

EID: 66349103877     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.028     Document Type: Article

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15. 4 (14 μg). After 3 min at room temperature, ammonium phosphate buffer (pH 9.4, 500 μL) was added to the reaction mixture. The contents of the resulting mixture were analyzed by HPLC.
16. Retention times from semi-preparative HPLC were 4.5 and 8.8 min for serinol and 2-aminoethaol respectively. Conditions: column J'sphere ODS-H80 (10 × 250 mm, 8 μm, YMC Co. Ltd), flow rate 3 mL/min, eluent 10/90 (EtOH/ammonium phosphate buffer pH 9.4), detector UV (210 nM).