Reduction of the risk of bacterial contamination of blood components through diversion of the first part of the donation of blood and blood components

Blood Transfusion

Volumn 7, Issue 2, 2009, Pages 86-93

  Liumbruno, Giancarlo Maria ^a,b,c   Catalano, Liviana ^a   Piccinini, Vanessa ^a   Pupella, Simonetta ^a   Grazzini, Giuliano ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b SAN GIOVANNI CALIBITA FATEBENEFRATELLI HOSPITAL   (Italy)

^c NONE   (Italy)

Author keywords

Bacterial contamination; Blood component; Blood donation; Diversion volume; Platelets

Indexed keywords

BACTERIUM CONTAMINATION; BLOOD COMPONENT; BLOOD DONOR; BLOOD SAMPLING; BLOOD TRANSFUSION; HUMAN; INFECTION PREVENTION; REVIEW; RISK REDUCTION; SEPSIS; SKIN DECONTAMINATION; SKIN FLORA;

BACTERIAL INFECTIONS; BLOOD BANKS; BLOOD DONORS; BLOOD SPECIMEN COLLECTION; BLOOD TRANSFUSION; COLONY COUNT, MICROBIAL; EQUIPMENT DESIGN; EVIDENCE-BASED MEDICINE; HUMANS; QUALITY CONTROL; RISK;

EID: 66349101982     PISSN: 17232007     EISSN: None     Source Type: Journal    
DOI: 10.2450/2008.0026-08     Document Type: Review

References (60)

1. AuBuchon JP, Birkmeyer JD, Busch MP. Safety of the blood supply in the United States: opportunities and controversies. Ann Intern Med 1997; 127: 904-909 (Pubitemid 27490628)
2. Hillyer CD, Josephson CD, Blajchman MA, et al. Bacterial contamination of blood components: risks, strategies, and regulation: joint ASH and AABB educational session in transfusion medicine. Hematology Am Soc Hematol Educ Program 2003; 575-589
3. Stramer LS. Current risks of transfusion-transmitted agents: a review. Arch Pathol Lab Med 2007; 131: 702-707 (Pubitemid 46729528)
4. Dodd RY. Current risk for transfusion transmitted infections. Curr Opin Hematol 2007; 14: 671-676 (Pubitemid 47494085)
5. Blajchman MA, Beckers EAM, Dickmeiss E, et al. Bacterial detection of platelets: current problems and possible resolutions. Transfus Med Rev 2005; 19: 259-272 (Pubitemid 41415653)
6. O'Brien SF, Yi QL, Fan W, et al. Current incidence and estimated residual risk of transfusion-transmitted infections in donations made to Canadian Blood Services. Transfusion 2007; 47: 316-325 (Pubitemid 46150983)
7. Blajchman MA. Bacterial contamination of cellular blood components: risks, sources and control. Vox Sang 2004; 87 (Suppl 1): S98-103. (Pubitemid 39159033)
8. American Association of Blood Banks. Guidance On Implementation Of New Bacterial Reduction And Detection Standard. Bethesda, MD: AABB; August 29, 2003. Association Bulletin 03-10.
9. Alter HJ. Pathogen reduction: a precautionary principle paradigm. Transfus Med Rev 2008; 22: 97-102.
10. Blajchman MA. Incidence and significance of the bacterial contamination of blood components. Dev Biol (Basel) 2002; 108: 59-67.
11. Barrett BB, Anderson JW, Anderson KC. Strategies for the avoidance of bacterial contamination of blood components. Transfusion 1993; 33: 228-233 (Pubitemid 23073646)
12. Yomtovian R, Lazarus HM, Goodnough LT, et al. A prospective microbiologic surveillance program to detect and prevent the transfusion of bacterially contaminated platelets. Transfusion 1993; 33: 902-909 (Pubitemid 24004749)
13. Chiu EKW, Yuen KY, Lie AKW, et al. A prospective study of symptomatic bacteremia following platelet transfusion and of its management. Transfusion 1994; 34: 950-954 (Pubitemid 24373766)
14. Blajchman MA, Ali A, Lyn P, et al. A prospective study to determine the frequency of bacterial contamination in random donor platelet concentrates [abstract]. Blood 1994; 84: 529.
15. Leiby DA, Kerr KL, Compos JM, Dodd RY. A retrospective analysis of microbial contaminants in outdated random-donor platelets from multiple sites. Transfusion 1997; 37: 259-263 (Pubitemid 27142852)
16. Blajchman MA, Ali A, Lyn P, et al. Bacterial surveillance of platelet concentrates: quantitation of bacterial load [abstract]. Transfusion 1997; 37 (Suppl): 74S.
17. Blajchman MA, Ali AM. Bacteria in the blood supply: an overlooked issue in transfusion medicine. In: Nance SJ, editor. Blood Safety: Current Challenges, Bethesda, MD: AABB; 1992. p.213-228
18. Dzieczkowski JS, Barrett BB, Nester D, et al. Characterization of reactions after exclusive transfusion of white cell-reduced cellular blood components. Transfusion 1995; 35: 20-25
19. AuBuchon JP, Cooper LK, Leach MF, et al. Experience with universal bacterial culturing to detect contamination of apheresis platelet units in a hospital transfusion service. Transfusion 2002; 42: 855-861
20. Beckers EAM. Effects of bacterial testing: what risks are remaining? ISBT Science Series 2007; 2: 30-34
21. Brecher ME, Hay SN. Bacterial contamination of blood components. Clin Microbiol Rev 2005; 18: 195-204. (Pubitemid 40170668)
22. Reading FC, Brecher ME. Transfusion-related bacterial sepsis. Curr Opin Hematol 2001; 8: 380-388 (Pubitemid 33032920)
23. Kuehnert MJ, Roth VR, Haley NR, et al. Transfusion-transmitted bacterial infection in the United States, 1998 through 2000. Transfusion 2001; 41: 1493-1499
24. Ness P, Braine H, King K, et al. Single-donor platelets reduce the risk of septic platelet transfusion reactions. Transfusion 2001; 41: 857-861 (Pubitemid 32642756)
25. Council of Europe. Guide to the Preparation, Use and Quality Assurance of Blood Components. Recommendation No R (95) 15 on the Preparation, Use and Quality Assurance of Blood Components, 14th ed, Strasbourg, Council of Europe Press; 2008.
26. Decreto del Ministro della Salute 3 Marzo 2005. Caratteristiche e modalità per la donazione di sangue e di emocomponenti. Gazzetta Ufficiale della Repubblica Italiana n. 85, 13 Aprile 2005.
27. Vasconcelos E, Seghatchian J. Bacterial contamination in blood components and preventative strategies: an overview. Transfus Apher Sci 2001; 31: 155-163
28. McDonald CP. Bacterial risk reduction by improved donor arm disinfection, diversion and bacterial screening. Transfus Med 2006; 16: 381-396 (Pubitemid 44813848)
29. Gibson T, Norris W. Skin fragments removed by injection needles. Lancet 1958; 2: 983-985
30. Wagner SJ. Transfusion-transmitted bacterial infection: risks, sources and interventions. Vox Sang 2004; 86: 157-163 (Pubitemid 38529504)
31. Kojima K, Togashi T, Hasegawa K, Kawasaki H. Subcutaneous fatty tissue can stray into a blood bag [abstract]. Vox Sang 1998; 74 (Suppl 1): 1205.
32. Butchta C, Nedorost N, Regele H, et al. Skin plugs in phlebotomy puncture for blood donation. Wien Klin Wochenschr 2005; 117: 141-144 (Pubitemid 40515931)
33. Eder AF, Kennedy JM, Dy BA, et al. Bacterial screening of apheresis platelets and the residual risk of septic transfusion reactions: the American Red Cross experience (2004-2006). Transfusion 2007; 47: 1134-1142
34. Olthuis H, Puylaart C, Verhagen C, Valk L. Method for removal of contaminating bacteria during venapuncture [abstract]. Proceedings V Regional ISBT Congress 1995; 77.
35. Figueroa PI, Yoshimori R, Nelson E, et al. Distribution of bacteria in fluid passing through an inoculated collection needle [abstract]. Transfusion 1995; 35 (Suppl 1): 11S.
36. Wagner SJ, Robinette D, Friedman LI, Miripol J. Diversion of initial blood flow to prevent whole-blood contamination by skin surface bacteria: an in vitro model. Transfusion 2000; 40: 335-338 (Pubitemid 30171685)
37. Bruneau C, Perez P, Chassaigne M, et al. Efficacy of a new collection procedure for preventing bacterial contamination of whole-blood donations. Transfusion 2001; 41: 74-81. (Pubitemid 32142249)
38. Schneider T, Tunez T, Fontaine O. Benefits of the predonation sampling pouch in order to reduce bacterial contamination of pooled platelet concentrates [abstract]. Vox Sang 2002; 83 (Suppl 2): 162.
39. Bos H, Yedema TH, Luten M. Reduction of the incidence on bacterial contamination by predonating drawing blood for safety tests [abstract]. Vox Sang 2002; 83 (Suppl 2): 6.
40. Yedema T, Curvers J, De Kort W, Bos H. Reduction of the incidence of bacterial contamination of thrombocyte concentrates [abstract]. Transfusion 2003; 43 (Suppl): 51A.
41. de Korte D, Marcelis JH, Verhoeven AJ, Soeterbock AM. Diversion of first blood volume results in a reduction of bacterial contamination for whole-blood collections. Vox Sang 2002; 83: 13-16 (Pubitemid 36806493)
42. de Korte D, Curvers J, Beckers E, Marcelis J. Bacterial contamination of platelet concentrates: status after implementation of diversion in the Netherlands [abstract]. Transfusion 2005; 45 (Suppl); 26A.
43. de Korte D, Curvers J, de Kort WLAM, et al. Effects of skin disinfection method, deviation bag, and bacterial screening on clinical safety of platelet transfusions in the Netherlands. Transfusion 2006; 46: 476-485 (Pubitemid 43334104)
44. de Korte D, Curvers J, Beckers EA, Marcelis JH. 5 years bacterial screening of PC in the Netherlands [abstract]. Transfusion 2007; 47 (Suppl 3): 197A-98A.
45. McDonald CP, Roy A, Mahajan P, et al. Relative values of the interventions of diversion and improved donorarm disinfection to reduce the bacterial risk from blood transfusion. Vox Sang 2004; 86: 178-182 (Pubitemid 38529507)
46. Robillard P, Nawej K, Delage G. Platelet bacterial contaminations and effectiveness of diverting the first 40 mls at whole blood donation [abstract]. Transfusion 2005; 45 (Suppl): 25A.
47. Delage G, Itaj NK, Robillard P. Cumulative effect of preventive measures on incidence of bacterial infections in platelet recipients [abstract]. Transfusion 2006; 46 (Suppl 2): 33A.
48. Stainsby D, Jones H, Asher D, et al. Serious hazards of transfusion: a decade of hemovigilance in the UK. Transfus Med Rev 2006; 20: 273-282 (Pubitemid 44428107)
49. Serious Hazards Of Transfusion (SHOT). Reports and summaries. Available at: http://www.shotuk.org/SHOT%20reports%20&%20Summaries.htm.
50. Murphy WG, Foley M, Doherty C, et al. Screening platelet concentrates for bacterial contamination: low numbers of bacteria and slow growth in contaminated units mandate an alternative approach to product safety. Vox Sang 2008; 95: 13-19
51. Walther-Wenke G, Doerner R, Montag T, et al. Bacterial contamination of platelet concentrates prepared by different methods: results of standardized sterility testing in Germany. Vox Sang 2006; 90: 177-182 (Pubitemid 43320011)
52. Andreau G, Caldani C, Morel P. Reduction of septic transfusion reactions related to bacteria contamination without implementing bacteria detection. ISBT Science Series 2008; 3: 124-132
53. Decreto Legislativo 9 novembre 2007, n. 208. Attuazione della direttiva 2005/62/CE che applica la direttiva 2002/98/CE per quanto riguarda le norme e le specifiche comunitarie relative ad un sistema di qualità per i servizi trasfusionali. Gazzetta Ufficiale della Repubblica Italiana - Serie Generale n. 261 del 9-11-2007 - Supplemento Ordinario n. 228.
54. Rao PL, Strausbaugh LJ, Liedtke LA, et al. Bacterial infections associated with blood transfusion: experience and perspective of infectious diseases consultants. Transfusion 2007; 47: 1206-1211 (Pubitemid 46934321)
55. Decreto del Ministro della Salute 3 Marzo 2005. Protocolli per l'accertamento della idoneità del donatore di sangue e di emocomponenti. Gazzetta Ufficiale della Repubblica Italiana n. 85, 13 Aprile 2005.
56. Yomtovian R, Tomasulo P, Jacobs MR. Platelet bacterial contamination: assessing progress and identifying quandaries in a rapidly evolving field [editorial]. Transfusion 2007; 47: 1340-1346 (Pubitemid 47101092)
57. Yomtovian R. Bacterial contamination of blood: lessons from the past and road map for the future. Transfusion 2004; 44: 450-460 (Pubitemid 38365524)
58. Benjamin RJ. Bacterial culture of apheresis platelet products and the residual risk of sepsis. ISBT Science Series 2008; 3: 133-138
59. Benjamin RJ, Wagner S. The residual risk of sepsis: modeling bacterial detection in a two bottle culture system and an analysis of sampling error. Transfusion 2007; 47: 1381-1389
60. Cole B, Smith T. PASSPORT Post Approval Surveillance Study of Platelet Outcomes, Release Tested. January 29, 2008. Available at: http://www. passportstudy.com/documents/PassportLetter.pdf. Downloaded on July 7, 2008.