Enhanced methylglyoxal formation in the erythrocytes of hemodialyzed patients

Metabolism: Clinical and Experimental

Volumn 58, Issue 7, 2009, Pages 976-982

  Karg, Eszter ^a   Papp, Ferenc ^a   Tassi, Noemi ^a   Janáky, Tamás ^a   Wittmann, Gyula ^a   Túri, Sándor ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; GLUTATHIONE; GLYOXALASE; HYDROXYACYLGLUTATHIONE HYDROLASE; LACTIC ACID; LACTOYLGLUTATHIONE LYASE; METHYLGLYOXAL;

ADULT; ARTICLE; BLOOD; CELL LEVEL; CELL METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; DEGRADATION; ENZYME ACTIVITY; ERYTHROCYTE; FEMALE; GLUCOSE METABOLISM; HEMODIALYSIS PATIENT; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IN VITRO STUDY; KIDNEY FAILURE; MALE; METABOLIC DISORDER; METABOLIC STRESS; PRIORITY JOURNAL;

ADULT; CASE-CONTROL STUDIES; ERYTHROCYTES; FEMALE; GLUTATHIONE; HUMANS; KIDNEY FAILURE, CHRONIC; LACTIC ACID; LACTOYLGLUTATHIONE LYASE; MALE; MIDDLE AGED; PYRUVALDEHYDE; RENAL DIALYSIS; TANDEM MASS SPECTROMETRY; THIOLESTER HYDROLASES;

EID: 66349099283     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.02.032     Document Type: Article

References (48)

1. Miyata T., Ueda Y., Yamada Y., et al. Accumulation of carbonyls accelerates the formation of pentosidine, an advanced glycation end product: carbonyl stress in uremia. J Am Soc Nephrol 9 (1998) 2349-2356
2. Miyata T., van Ypersele de Strihou C., Kurokawa K., and Baynes J.W. Alterations in nonenzymatic biochemistry in uremia: origin and significance of "carbonyl stress" in long-term uremic complications. Kidney Int 55 (1999) 389-399
3. Stopper H., Schinzel R., Sebekova K., and Heidland A. Genotoxicity of advanced glycation end products in mammalian cells. Cancer Lett 190 (2003) 151-156
4. Odani H., Shinzato T., Matsumuto Y., Usami J., and Maeda K. Increase in three alpha,beta-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction. Biochem Biophys Res Commun 256 (1999) 89-93
5. Degenhardt T.P., Thorpe S.R., and Baynes J.W. Chemical modification of proteins by methylglyoxal. Cell Mol Biol (Noisy-le-grand) 44 (1998) 1139-1145
6. Odani H., Shinzato T., Matsumuto Y., Brinkmann Frye E., Baynes J.W., and Maeda K. Imidazolium crosslinks derived from reaction of lysine with glyoxal and methylglyoxal are increased in serum proteins of uremic patients: evidence for increased oxidative stress in uremia. FEBS Lett 427 (1998) 381-385
7. Miyata T., Wada Y., Caiu Z., et al. Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure. Kidney Int 51 (1997) 1170-1181
8. Thornalley P.J. The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life. Biochem J 269 (1990) 1-11
9. Thornalley P.J. Glyoxalase I-structure, function and a critical role in the enzymatic defence against glycation. Biochem Soc Trans 31 (2003) 1343-1348
10. Staniszewska M.M., and Nagaraj R.H. Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses. Mol Cell Biochem 288 (2006) 29-36
11. Klemm A., Voigt C., Friedrich M., Funfstuck R., et al. Determination of erythrocyte antioxidant capacity in haemodialysis patients using electron paramagnetic resonance. Nephrol Dial Transplant 16 (2001) 2166-2171
12. Suliman M.E., Divino Filho J.C., Barany P., Anderstam B., Lindholm B., and Bergstrom J. Effects of high-dose folic acid and pyridoxine on plasma and erythrocyte sulfur amino acids in hemodialysis patients. J Am Soc Nephrol 10 (1999) 1287-1296
13. Miyata T., van Ypersele de Strihou C., Imasawa T., et al. Glyoxalase I deficiency is associated with an unusual level of advanced glycation end products in a hemodialysis patient. Kidney Int 60 (2001) 2351-2359
14. Randell E.W., Vasdev S., and Gill V. Measurement of methylglyoxal in rat tissues by electrospray ionization mass spectrometry and liquid chromatography. J Pharmacol Toxicol Methods 51 (2005) 153-157
15. Dobler D., Ahmed N., Song L., Eboigbodin K.E., and Thornalley P.J. Increased dicarbonyl metabolism in endothelial cells in hyperglycemia induces anoikis and impairs angiogenesis by RGD and GFOGER motif modification. Diabetes 55 (2006) 1961-1969
16. Thornalley P.J., Jahan I., and Ng R. Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro. J Biochem 129 (2001) 543-549
17. Anderson Y.S., Curtis N.J., Hobbs J.A.R., et al. High serum d-lactate in patients on continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant 12 (1997) 981-983
18. McLellan A.C., and Thornalley P.J. Sample storage conditions for the assay of glyoxalase activities in whole blood samples. Ann Clin Biochem 29 (1992) 222-223
19. Nemeth I., and Boda D. Blood glutathione redox ratio as a parameter of oxidative stress in premature infants with IRDS. Free Radic Biol Med 16 (1994) 347-353
20. Miyata T., Kurokawa K., and van Ypersele de Strihou C. Advanced glycation and lipoxidation end products: role of reactive carbonyl compounds generated during carbohydrate and lipid metabolism. J Am Soc Nephrol 11 (2000) 1744-1752
21. Lapolla A., Flamini R., Lupo A., et al. Evaluation of glyoxal and methylglyoxal levels in uremic patients under peritoneal dialysis. Ann N Y Acad Sci 1043 (2005) 217-224
22. DeFronzo R.A., Alvestrand A., Smith D., Hendler R., Hendler E., and Wahren J. Insulin resistance in uremia. J Clin Invest 67 (1981) 563-568
23. Bilbrey G.L., Faloona G.R., White M.G., and Knochel J.P. Hyperglucagonemia of renal failure. J Clin Invest 53 (1974) 841-847
24. Rubenfeld S., and Garber A.J. Abnormal carbohydrate metabolism in chronic renal failure. The potential role of accelerated glucose production, increased gluconeogenesis, and impaired glucose disposal. J Clin Invest 62 (1978) 20-28
25. Maillet C., and Garber A.J. Skeletal muscle amino acid metabolism in chronic uremia. Am J Clin Nutr 33 (1980) 1343-1353
26. Weisinger J.R., Contreras N.E., Cajias J., Bellorin-Font E., Amair P., Guitierrez L., et al. Insulin binding and glycolytic activity in erythrocytes from dialyzed and nondialyzed uremic patients. Nephron 48 (1988) 190-196
27. Wann J.G., Lin C.S., Chang L.C., et al. Enhanced expression of glucose transporter 1 on erythrocyte membrane in hemodialysis patients: the possible role in erythrocyte ascorbate recycling. Am J Kidney Dis. 47 (2006) 1055-1063
28. Foss M.C., Gouveia L.M., Moyses Neto M., Paccola G.M., and Piccinato C.E. Effect of hemodialysis on peripheral glucose metabolism of patients with chronic renal failure. Nephron. 73 (1996) 48-53
29. Quintanilla A., Shambaugh III G.E., Gibson T.P., and Craig R. Glucose metabolism in uremia. Am J Clin Nutr 33 (1980) 1446-1450
30. Rigalleau V., and Gin H. Carbohydrate metabolism in uraemia. Curr Opin Clin Nutr Metab Care 8 (2005) 463-469
31. Yawata Y., and Jacobs H.S. Abnormal red cell metabolism in patients with chronic uremia: nature of the defect and its persistence despite adequate hemodialysis. Blood 45 (1975) 231-239
32. Lonergan E.T., Semar M., Sterzel R.B., et al. Erythrocyte transketolase activity in dialyzed patients. A reversible metabolic lesion of uremia. N Engl J Med 284 (1971) 1399-1403
33. Taccone-Galluci M., Lubrano R., Trapasso E., et al. Oxidative damage to RBC membranes and pentose phosphate shunt activity in hemodialysis patients after suspension of erythropoietin treatment. ASAIO J 40 (1994) M663-M666
34. Vander Jagt D.L., and Hundsaker L.A. Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase. Chem Biol Interact 143-144 (2003) 341-351
35. Martins A.M., Mendes P., Cordeiro C., and Freire A.P. In situ kinetic analysis of glyoxalase I and glyoxalase II in Saccharomyces cerevisiae. Eur J Biochem 268 (2001) 3930-3936
36. McLellan A.C., and Thornalley P.J. Glyoxalase activity in human red blood cells fractioned by age. Mech Ageing Dev 48 (1989) 63-71
37. Breborowicz A., Witowski J., Polubinska A., Pyda M., and Oreopulos D. l-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products. Nephrol Dial Transplant 19 (2004) 3005-3011
38. Valentine W.N., Paglia D.E., Neerhout R.C., and Konrad P.N. Erythrocyte glyoxalase II deficiency with coincidental hereditary elliptocytosis. Blood 36 (1970) 797-808
39. Hooper N.I., Tisdale M.J., and Thornalley P.J. Modification of the glyoxalase system in human HL60 promyelocytic leukaemia cells during differentiation to neutrophils in vitro. Biochim Biophys Acta 966 (1988) 362-369
40. Xu Y., and Chen X. Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family. J Biol Chem 281 (2006) 26702-26713
41. Karg E., Nemeth I., Horanyi M., Pinter S., Vecsei L., and Hollan S. Diminished blood levels of reduced glutathione and alpha-tocopherol in two triosephosphate isomerase-deficient brothers. Blood Cells Mol Dis 26 (2000) 91-100
42. Ewaschuk J.B., Naylor J.M., and Zello G.A. d-lactate in human and ruminant metabolism. J Nutr 135 (2005) 1619-1625
43. Oh M.S., Uribarri J., Alveranga D., Lazar I., Bazilinski N., and Carrol J.H. Metabolic utilization and renal handling of d-lactate in men. Metabolism 34 (1985) 621-625
44. Fafoumoux P., Demigne C., and Remesy C. Carrier-mediated uptake of lactate in rat hepatocytes. Effects of pH and possible mechanisms for l-lactate transport. J Biol Chem 260 (1985) 292-299
45. de Bari L., Atlante A., Guaragnella N., Principato G., and Passarella S. d-Lactate transport and metabolism in rat liver mitochondria. Biochem J 365 (2002) 391-403
46. Harmon D.L., Britton R.A., and Prior R.L. In vitro rates of oxidation and gluconeogenesis from l(+)- and d(-)lactate in bovine tissues. Comp Biochem Physiol B 77 (1984) 365-368
47. Flick M.J., and Konieczny S.F. Identification of putative mammalian d-lactate dehydrogenase enzymes. Biochem Biophys Res Commun 295 (2002) 910-916
48. Brandt R.B., Waters M.G., Rispler M.J., and Kline E.S. d- and l-lactate catabolism to CO2 in rat tissues. Proc Soc Exp Biol Med 175 (1984) 328-335