Disruption of Thyroid Hormone Function by Environmental Pollutants

Journal of Health Science

Volumn 55, Issue 2, 2009, Pages 147-160

  Kashiwagi, Keiko ^a   Furuno, Nobuaki ^a   Kitamura, Shigeyuki ^b   Ohta, Shigeru ^c   Sugihara, Kazumi ^c   Utsumi, Kozo ^d   Hanada, Hideki ^a   Taniguchi, Kikuyo ^e   Suzuki, Ken Ichi ^a   Kashiwagi, Akihiko ^a,e  

^a HIROSHIMA UNIVERSITY   (Japan)

^b NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

^e Sanyo Women's College   (Japan)

Author keywords

Amphibian metamorphosis; Bisphenol a related compound; Brominated flame retardant; Environmental pollutant; Polychlorinated biphenyl; Thyroid hormone disruption

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ENDOCRINE DISRUPTOR; FLAME RETARDANT; GLUCURONOSYLTRANSFERASE; HEAVY METAL; PHTHALIC ACID DERIVATIVE; POLYCHLORINATED BIPHENYL DERIVATIVE; SUNSCREEN; THYROID HORMONE; THYROID HORMONE RECEPTOR;

DEVELOPMENT; ENZYME MECHANISM; GROWTH REGULATION; HOMEOSTASIS; HORMONE ACTION; HUMAN; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; METABOLIC BALANCE; METAMORPHOSIS; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE PERMEABILITY TRANSITION; NONHUMAN; PARAMETER; POLLUTANT; REVIEW; SIGNAL TRANSDUCTION; TADPOLE; THYROID DISEASE; THYROXINE METABOLISM;

AMPHIBIA;

EID: 66249123644     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.55.147     Document Type: Review

References (143)

1. Boas, M., Feldt-Rasmussen, U., Skakkebk, N. E. and Main, K. M. (2006) Environmental chemi- cals and thyroid function. Eur. J. Endocrinol., 154, 599-611.
2. Zoeller, R. T. (2005) Environmental chemicals as thyroid hormone analogues: new studies indicate that thyroid hormone receptors are targets of in- dustrial chemicals? Mol. Cell. Endocrinol., 242, 10-15.
3. Markey, C. M., Rubin, B. S., Soto, A. M. and Sonnenschein, C. (2002) Endocrine disruptors: from Wingspread to environmental developmental biology. J. Steroid Biochem. Mol. Biol., 83, 235-244.
4. Schantz, S. L. and Widholm, J. J. (2001) Cogni- tive effects of endocrine-disruping chemicals in an- imals. Environ. Health Perspect., 109, 1197-1206.
5. Birnbaum, L. S. and Staskal, D. F. (2004) Bromi- nated flame retardants: cause for concern? Envi- ron. Health Perspect., 112, 9-17.
6. Darnerud, P. O. (2003) Toxic effects of brominated flame retardants in man and in wildlife. Environ. Int., 29, 841-853.
7. Schlumpf, M., Durrer, S., Faass, O., Ehnes, C., Fuetsch, M., Gaille, C., Henseler, M., Hofkamp, L., Maerkel, K., Reolon, S., Timms, B., Tresguerres, J. A. F. and Lichtensteiger, W. (2008) Developmental toxicity of UV filters and environ- mental exposure: a review. Int. J. Androl., 31, 1-7.
8. Herbst, A. L., Ulfelder, H. and Poskanzer, D. C. (1971) Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumor appear- ance in young women. N. Engl. J. M ed., 284, 878-881.
9. Brucker-Davis, F. (1998) Effects of environmental synthetic chemicals on thyroid function. Thyroid, 8, 827-856.
10. Tata, J. R. (1999) Amphibian metamorphosis as a model for studying the developmental actions of thyroid hormone. Biochimie, 81, 359-366.
11. Silva, J. E. (2001) The multiple contributions of thyroid hormone to heat production. J. Clin. In- vest., 108, 35-37.
12. Yen, P. M. (2001) Physiological and molecular ba- sis of thyroid hormone action. Physiol. Rev., 81, 1097-1142.
13. Porterfield, S. P. and Hendrich, C. E. (1993) The role of thyroid hormones in prenatal and neonatal neurological development-current perspectives. Endocr. Rev., 14, 94-106.
14. Chan, S. and Kilby, M. D. (2000) Thyroid hor- mone and central nervous system development. J. Endocrinol., 165, 1-8.
15. Thompson, C. C. and Potter, G. B. (2000) Thy- roid hormone action in neural development. Cereb. Cortex, 10, 939-945.
16. Dussault, J. H. and Ruel, J. (1987) Thyroid hor- mones and brain development. Annu. Rev. Physiol., 49, 321-334.
17. Timiras, P. S. and Nzekwe, E. U. (1989) Thyroid hormones and nervous system development. Biol. Neonate, 55, 376-385.
18. Krude, H., Biebermann, H., Krohn, H. P., Dralle, H. and Gr̈uters, A. (1997) Congenital hyperthy- roidism. Exp. Clin. Endocrinol. Diabetes, 105 (Suppl. 4), 6-11.
19. Boyages, S. C. and Halpern, J. P. (1993) Endemic cretinism: toward a unifying hypothesis. Thyroid, 3, 59-69.
20. Miculan, J., Turner, S. and Paes, B. A. (1993) Congenital hypothyroidism: diagnosis and man- agement. Neonatal Netw., 12, 25-34.
21. Delange, F. (1997) Neonatal screening for con- genital hypothyroidism: results and perspectives. Horm. Res., 48, 51-61.
22. Miyazaki, W., Iwasaki, T., Takeshita, A., Kuroda, Y. and Koibuchi, N. (2004) Polychlorinated biphenyls suppress thyroid hormone receptor- mediated transcription through a novel mechanism. J. Biol. Chem., 279, 18195-18202.
23. Zoeller, R. T., Tan, S. W. and Tyl, R. W. (2007) General background on the hypothalamic- pituitary-thyroid (HPT) axis. Crit. Rev. Toxicol., 37, 11-53.
24. Zoeller, R. T., Tyl, R. W. and Tan, S. W. (2007) Current and potential rodent screens and tests for thyroid toxicants. Crit. Rev. Toxicol., 37, 55-95.
25. K̈uhn, E. R. (1990) Hormonal control of peripheral monodeiodination in vertebrates. Prog. Clin. Biol. Res., 342, 421-426.
26. Sefkow, A. J., DiStefano, J. J., Himick, B. A., Brown, S. B. and Eales, J. G. (1996) Kineticanalysis of thyroid hormone secretion and inter- conversion of the 5-day-fasted rainbow trout, On- corhynchus mykiss. Gen. Comp. Endocrinol., 101, 123-138.
27. Bentley, P. J. (1998) The life history of hormones. In Comparative Vertebrate Endocrinology, Cam- bridge University Press, Cambridge, U. K., 177-221.
28. Kollros, J. J. (1961) Mechanisms of amphibian metamorphosis: hormones. Am. Zool., 1, 107-114.
29. Kaltenbach, J. C. (1966) Endocrinology of amphibian metamorphosis. In Metamorphosis: Postembryonic Reprogramming of Gene Expres- sion in Amphibian and Insect Cells (Gilbert, L. I., Tata, J. R. and Atkinson, B. G., Eds.), Academic Press, New York, 403-431.
30. Dodd, M. H. and Dodd, L. M. (1976) The biology of metamorphosis. In Physiology of the Amphibia, 3 (Lofts, B., Ed.), Academic Press, New York, SanFrancisco, London, 467-599.
31. Zhang, J. and Lazar, M. A. (2000) The mechanism of action of thyroid hormones. Annu. Rev. Physiol., 62, 439-466.
32. Shi, Y.-B. (2000) Amphibian Metamorphosis, Wiley-Liss, New York, Chichester, Weinheim, Brisbane, Singapore, Toronto.
33. Goto, Y., Kitamura, S., Kashiwagi, K., Oofusa, K., Tooi, O., Yoshizato, K., Sato, J., Ohta, S. and Kashiwagi, A. (2006) Suppression of amphibian metamorphosis by bisphenol A and related chemi- cal substances. J. Health Sci., 52, 160-168.
34. Lechan, R. M. and Fekete, C. (2006) Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Pep- tides, 27, 310-325.
35. DeVito, M., Biegel, L., Brouwer, A., Brown, S., Brucker-Davis, F., Cheek, A. O., Christensen, R., Colborn, T., Cooke, P., Crissman, J., Crofton, K., Doerge, D., Gray, E., Hauser, P., Hurley, P., Kohn, M., Lazar, J., McMaster, S., McClain, M., McConnell, E., Meier, C., Miller, R., Tietge, J. and Tyl, R. (1999) Screening methods for thyroid hor- mone disruptors. Environ. Health Perspect., 107, 407-415.
36. Lehigh Shirey, E. A., Jelaso Langerveld, A., Mihalko, D. and Ide, C. F. (2006) Polychlorinated biphenyl exposure delays metamorphosis and al- ters thyroid hormone system gene expression in de- veloping Xenopus laevis. Environ. Res., 102, 205-214.
37. Connell, D. W. (1997) Basic Concepts of Environ- mental Chemistry, CRC Press LLC, Boca Raton, FL, 125-148.
38. ATSDR (2000) Toxicological Profile for Polychlo- rinated Biphenyls (update), USDepartment of Health and Human Services, Atlanta, GA, 5-9.
39. WHO (2003) Polychlorinated Biphenyls: Human Health Aspects. Concise International Chemical Assessment Document 55, p. 36.
40. Jones, K. C. (1988) Determination of polychlori- nated biphenyls in human foodstuffs and tissues: suggestions for a selective congener analytical ap- proach. Sci. Total Environ., 68, 141-159.
41. McFarland, V. A. and Clarke, J. U. (1989) Environ- mental occurrence, abundance, and potential toxic- ity of polychlorinated biphenyl congeners: consid- erations for a congener-specific analysis. Environ. Health Perspect., 81, 225-239.
42. Brouwer, A., Morse, D. C., Lans, M. C., Schuur, A. G., Murk, A. J., Klosson-Wehler, E., Bergman, Å. and Visser, T. J. (1998) Interactions of persis- tent environmental organohalogens with the thy- roid hormone system: mechanisms and possible consequences for animal and human health. Toxi- col. Ind. Health, 14, 59-84.
43. Hansen, L. G. (1999) The ortho Slide of PCBs: Oc- currence and Disposition, KluwerAcademic Pub- lishers, Boston.
44. Morse, D. C., Klasson-Wehler, E., Wesseling, W., Koeman, J. H. and Brouwer, A. (1996) Alter- ations in rat brain thyroid hormone status follow- ing pre- and postnatal exposure to polychlorinated biphenyls (Aroclor 1254). Toxicol. Appl. Pharma- col., 136, 269-279.
45. Porterfield, S. P. (1994) Vulnerability of the devel- oping brain to thyroid abnormalities: environmen- tal insults to the thyroid system. Environ. Health Perspect., 102 (Suppl. 2), 125-130.
46. Bergman, Å., Klasson-Wehler, E. and Kuroki, H. (1994) Selective retention of hydroxylated PCB metabolites in blood. Environ. Health Perspect., 102, 464-469.
47. Sj̈odin, A., Hagmar, L., Klasson-Wehler, E., Bj̈ork, J. and Bergman, Å. (2000) Influence of the con- sumption of fatty Baltic sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men. Environ. Health Perspect., 108, 1035-1041.
48. Meerts, I. A. T. M., Lilienthal, H., Hoving, S., van den Berg, J. H. J., Weijers, B. M., Bergman, Å., Koeman, J. H. and Brouwer, A. (2004) Developmental exposure to 4-hydroxy-2, 3, 3, 4, 5-pentachlorobiphenyl (4-OH-CB107) : long-term effects on brain development, behavior, and brain stem auditory evoked potentials in rats. Toxicol. Sci., 82, 207-218.
49. Kiliç, N., Sandal, S., Çolakoglu, N., Kutlu, S., Seyran, A. and Yilmaz, B. (2005) Endocrine dis- ruptive effects of polychlorinated biphenyls on the thyroid gland in female rats. Tohoku J. Exp. M ed., 206, 327-332.
50. McKinney, J. D. and Waller, C. L. (1994) Polychlo- rinated biphenyls as hormonally active structural analogues. Environ. Health Perspect., 102, 290-297.
51. Ulbrich, B. and Stahlmann, R. (2004) Devel- opmental toxicity of polychlorinated biphenyls (PCBs) : a systematic review of experimental data. Arch. Toxicol., 78, 252-268.
52. Khan, M. A. and Hansen, L. G. (2003) ortho- Substituted polychlorinated biphenyl (PCB) con- geners (95 or 101) decrease pituitary response to thyrotropin releasing hormone. Toxicol. Lett., 144, 173-182.
53. Anbalagan, J., Kanagaraj, P., Srinivasan, N., Aruldhas, M. M. and Arunakaran, J. (2003) Effect of polychlorinated biphenyl, Aroclor 1254 on rat epididymis. Indian J. Med. Res., 118, 236-242.
54. Hood, A. and Klaassen, C. D. (2000) Effects of microsomal enzyme inducers on outer-ring deiod- inase activity toward thyroid hormones in various rat tissues. Toxicol. Appl. Pharmacol., 163, 240-248.
55. Kato, Y., Ikushiro, S., Haraguchi, K., Yamazaki, T., Ito, Y., Suzuki, H., Kimura, R., Yamada, S., Inoue, T. and Degawa, M. (2004) A possible mechanism for decrease in serum thyroxine level by polychlo- rinated biphenyls in Wistar and Gunn rats. Toxicol. Sci., 81, 309-315.
56. Jelaso, A. M., DeLong, C., Means, J. and Ide, C. F. (2005) Dietary exposure to Aroclor 1254 alters gene expression in Xenopus laevis frogs. Environ. Res., 98, 64-72.
57. Gutleb, A. C., Appelman, J., Bronkhorst, M., van den Berg, J. H. J. and Murk, A. J. (2000) Effects of oral exposure to polychlorinated biphenyls (PCBs) on the development and metamorphosis of two am- phibian species (Xenopus laevis and Rana tempo- raria). Sci. Total Environ., 262, 147-157.
58. Gutleb, A. C., Schriks, M., Mossink, L., van den Berg, J. H. J. and Murk, A. J. (2007) A synchro- nized amphibian metamorphosis assay as an im- proved tool to detect thyroid hormone disturbance by endocrine disruptors and apolar sediment ex- tracts. Chemosphere, 70, 93-100.
59. Chauhan, K. R., Kodavanti, P. R. S. and McKinney, J. D. (2000) Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport pro- tein. Toxicol. Appl. Pharmacol., 162, 10-12.
60. Johansson, C., Tofighi, R., Tamm, C., Goldoni, M., Mutti, A. and Ceccatelli, S. (2006) Cell death mechanisms in AtT20 pituitary cells exposed to polychlorinated biphenyls (PCB 126 and PCB 153) and methylmercury. Toxicol. Lett., 167, 183-190
61. Goff, K. F., Hull, B. E. and Grasman, K. A. (2005) Effects of PCB 126 on primary immune organs and thymocyte apoptosis in chicken embryos. J. Toxi- col. Environ. Health A, 68, 485-500.
62. Fujita, H., Okimura, Y., Utsumi, T., Kitamura, S., Kuroki, H., Otsuki, T., Sasaki, J., Kashiwagi, A. and Utsumi, K. (2006) 4-Hydroxy-3, 5, 3, 4-tetrachlorobiphenyl induced membrane permeabil- ity transition in isolated rat liver mitochondria. Journal of Clinical Biochemisty and Nutrition, 38, 167-175.
63. Kashiwagi, A., Utsumi, K., Kashiwagi, K., Ohta, S., Sugihara, K., Hanada, H. and Kitamura, S. (2008) Effects of endocrine disrupting chemicals on amphibian metamorphosis and mitochondrial membrane permeability transition. J. Health Sci., 54, 273-280.
64. Krishnan, A. V., Stathis, P., Permuth, S. F., Tokes, L. and Feldman, D. (1993) Bisphenol-A: an es- trogenic substance is released from polycarbon- ate flasks during autoclaving. Endocrinology, 132, 2279-2286.
65. Howe, S. R., Borodinsky, L. and Lyon, R. S. (1998) Potential exposure to bisphenol A from food-contact use of epoxy coated cans. Journal of Coatings Technology, 70, 69-74.
66. Lewis, J. B., Rueggeberg, F. A., Lapp, C. A., Ergle, J. W. and Schuster, G. S. (1999) Identifica- tion and characterization of estrogen-like compo- nents in commercial resin-based dental restorative materials. Clin. Oral. Investig., 3, 107-113.
67. Brotons, J. A., Olea-Serrano, M. F., Villalobos, M., Pedraza, V. and Olea, N. (1995) Xenoestrogens re- leased from lacquer coatings in food cans. Environ. Health Perspect., 103, 608-612.
68. Yamamoto, T. and Yasuhara, A. (1999) Quantities of bisphenol A leached from plastic waste samples. Chemosphere, 38, 2569-2576.
69. Yoshida, T., Horie, M., Hoshino, Y. and Nakazawa, H. (2001) Determination of bisphenol A in canned vegetables and fruit by high performance liquid chromatography. Food Addit. Contam., 18, 69-75.
70. K̈orner, W., Bolz, U., S̈ußmuth, W., Hiller, G., Schuller, W., Hanf, V. and Hagenmaier, H. (2000) Input/output balance of estrogenic active com- pounds in a major municipal sewage plant in Ger- many. Chemosphere, 40, 1131-1142.
71. Fukazawa, H., Hoshino, K., Shiozawa, T., Matsushita, H. and Terao, Y. (2001) Identifica- tion and quantification of chlorinated bisphenol A in wastewater from wastepaper recycling plants. Chemosphere, 44, 973-979.
72. Scḧonfelder, G., Wittfoht, W., Hopp, H., Talsnesse, C. E., Paul, M. and Chahoud, I. (2002) Parent bisphenol A accumulation in the human maternal- fet al.-placental unit. Environ. Health Perspect., 110, A703-A707.
73. Ikezuki, Y., Tsutsumi, O., Takai, Y., Kamei, Y. and Taketani, Y. (2002) Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure. Hum. Reprod., 17, 2839-2841.
74. Sun, Y., Irie, M., Kishikawa, N., Wada, M., Kuroda, N. and Nakashima, K. (2004) Determina- tion of bisphenol A in human breast milk by HPLC with column-switching and fluorescence detection. Biomed. Chromatogr., 18, 501-507.
75. Howdeshell, K. L., Hotchkiss, A. K., Thayer, K. A., Vandenbergh, J. G. and vom Saal, F. S. (1999) Exposure to bisphenol A advances puberty. Nature, 401, 763-764.
76. Zoeller, R. T., Bansal, R. and Parris, C. (2005) Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/Neurogranin expression in the developing rat brain. Endocrinology, 146, 607-612.
77. Zoeller, R. T. (2007) Environmental chemicals im- pacting the thyroid: targets and consequences. Thy- roid, 17, 811-817.
78. Iwamuro, S., Sakakibara, M., Terao, M., Ozawa, A., Kurobe, C., Shigeura, T., Kato, M. and Kikuyama, S. (2003) Teratogenic and anti- metamorphic effects of bisphenol A on embry- onic and larval Xenopus laevis. Gen. Comp. En- docrinol., 133, 189-198.
79. Kitamura, S., Jinno, N., Ohta, S., Kuroki, H. and Fujimoto, N. (2002) Thyroid hormonal ac- tivity of the flame retardants tetrabromobisphenol Aandtetrachlorobisphenol A. Biochem. Biophys. Res. Commun., 293, 554-559.
80. Seiwa, C., Nakahara, J., Komiyama, T., Katsu, Y., Iguchi, T. and Asou, H. (2004) Bisphenol A exerts thyroid-hormone-like effects on mouse oligoden- drocyte precursor cells. Neuroendocrinology, 80, 21-30.
81. Moriyama, K., Tagami, T., Akamizu, T., Usui, T., Saijo, M., Kanamoto, N., Hataya, Y., Shimatsu, A., Kuzuya, H. and Nakao, K. (2002) Thyroid hor-158 55 (2009) mone action is disrupted by bisphenol A as an an- tagonist. J. Clin. Endocrinol. Metab., 87, 5185-5190.
82. Iwamuro, S., Yamada, M., Kato, M. and Kikuyama, S. (2006) Effects of bisphenol A on thyroid hormone-dependent up-regulation of thyroid hormone receptor and and down- regulation of retinoid X receptor in Xenopus tail culture. Life Sci., 79, 2165-2171.
83. Noiva, R. (1999) Protein disulfide isomerase: the multifunctional redox chaperone of the endoplas- mic reticulum. Semin. Cell Dev. Biol., 10, 481-493.
84. Turano, C., Coppari, S., Altieri, F. and Ferrano, A. (2002) Proteins of the PDI family: unpredicted non-ER locations and functions. J. Cell. Physiol., 193, 154-163.
85. Horiuchi, R., Johnson, M. L., Willingham, M. C., Pastan, I. and Cheng, S. (1982) Affinity labeling of the plasma membrane 3, 3, 5-triiodo-L-thyronine receptor in GH3 cells. Proc. Natl. Acad. Sci. U. S. A., 79, 5527-5531.
86. Hasumura, S., Kitagawa, S., Lovelace, E., Willingham, M. C., Pastan, I. and Cheng, S. (1986) Characterization of a membrane-associated 3, 3, 5-triiodo-L-thyronine binding protein by use of mon- oclonal antibodies. Biochemistry, 25, 7881-7888.
87. Hiroi, T., Okada, K., Imaoka, S., Osada, M. and Funae, Y. (2006) Bisphenol A binds to protein disulfide isomerase and inhibits its enzymatic and hormone-binding activities. Endocrinology, 147, 2773-2780.
88. Schlumpf, M., Cotton, B., Conscience, M., Haller, V., Steinmann, B. and Lichtensteiger, W. (2001) In vitro and in vivo estrogenicity of UV screens. Env- iron. Health Perspect., 109, 239-244.
89. Schecter, A., P̈apke, O., Harris, R., Tung, K. C., Musumba, A., Olson, J. and Birnbaum, L. (2006) Polybrominated diphenyl ether (PBDE) levels in an expanded market basket survey of U. S. food and estimated PBDE dietary intake by age and sex. En- viron. Health Perspect., 114, 1515-1520.
90. Kunz, P. Y., Galicia, H. F. and Fent, K. (2006) Comparison of in vitro and in vivo estrogenic activ- ity of UV filters in fish. Toxicol. Sci., 90, 349-361.
91. Poiger, T., Buser, H.- R., Balmer, M. E., Bergqvist, P.-A. and M̈uller, M. D. (2004) Occurrence of UV filtercompounds from sunscreens in surface wa- ters: regional mass balance in two Swiss lakes. Chemosphere, 55, 951-963.
92. Balmer, M. E., Busser, H. R., M̈uller, M. D. and Poiger, T. (2005) Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss lakes. Environ. Sci. Technol., 39, 953-962.
93. Nagtegaal, M., Ternes, T. A., Baumann, W. and Nagel, R. (1997) UV-Filtersubstanzen in Wasser und Fischen. UWSF-Z. Umweltchem. ̈ Okotox., 9, 79-86 (in German).
94. Maerkel, K., Durrer, S., Henseler, M., Schlumpf, M. and Lichtensteiger, W. (2007) Sexually dimor- phic gene regulation in brain as a target for en- docrine disruptors: developmental exposure of rats to 4-methylbenzylidene camphor. Toxicol. Appl. Pharmacol., 218, 152-165.
95. Hayden, C. G. J., Roberts, M. S. and Benson, H. A. E. (1997) Systemic absorption of sunscreen after topical application. Lancet, 350, 863-864.
96. Janjua, N. R., Mogensen, B., Andersson, A. M., Petersen, J. H., Henriksen, M., Skakkebaek, N. E. and Wulf, H. C. (2004) Systemic absorp- tion of the sunscreens benzophenone-3, octyl- methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. J. Invest. Dermatol., 123, 57-61.
97. Hany, J. and Nagel, R. (1995) Nachweis von UV- Filtersubstanzen in Muttermilch, Deut. Lebensm.- Rundsch., 91, 341-345 (in German).
98. Schmutzler, C., Bacinski, A., Gotthardt, I., Huhne, K., Ambrugger, P., Klammer, H., Schlecht, C., Hoang-Vu, C., Gr̈uters, A., Wuttke, W., Jarry, H. and K̈ohrle, J. (2007) The ultraviolet filter ben- zophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of hu- man recombinant thyroid peroxidase. Endocrinol- ogy, 148, 2835-2844.
99. Jarry, H., Christoffel, J., Rimoldi, G., Koch, L. and Wuttke, W. (2004) Multi-organic endocrine dis- rupting activity of the UV screen benzophenone 2 (BP2) inovariectomized adult rats after 5 days treatment. Toxicology, 205, 87-93.
100. Klammer, H., Schlecht, C., Wuttke, W., Schmutzler, C., Gotthardt, I., K̈ohrle, J. and Jarry, H. (2007) Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats. Toxicology, 238, 192-199.
101. Schlumpf, M., Schmid, P., Durrer, S., Conscience, M., Maerkel, K., Henseler, M., Gruetter, M., Herzog, I., Reolon, S., Ceccatelli, R., Faass, O., Stutz, E., Jarry, H., Wuttke, W. and Lichtensteiger, W. (2004) Endocrine activity and developmental toxicity of cosmetic UV filters-an update. Toxi- cology, 205, 113-122.
102. de Wit, C. A. (2002) An overview of brominated flame retardants in the environment. Chemosphere, 46, 583-624.
103. McDonald, T. A. (2002) A perspective on the po- tential health risks of PBDEs. Chemosphere, 46, 745-755.
104. McDonald, T. A. (2005) Polybrominated dipheny- lether levels among United States residents: daily intake and risk of harm to the developing brain and reproductive organs. Integrated Environmental As- sessment and Management, 1, 343-354.
105. KEMI (1990) Proc. Workshop on Brominated Aro- matic Flame Retardants, National Swedish Chem- icals Inspectorate, Solna, Sweden.
106. Thomsen, C., Lundanes, E. and Becher, G. (2002) Brominated flame retardants in archived serum samples from Norway: a study on temporal trends and the role of age. Environ. Sci. Technol., 36, 1414-1418.
107. Hooper, K. and McDonald, T. A. (2000) The PB- DEs: An emerging environmental challenge and another reason for breast milk-monitoring pro- grams. Environ. Health Perspect., 108, 387-392.
108. Darnerud, P. O. and Sinjari, T. (1996) Ef- fects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thy- roxine and TSH blood levels in rats and mice. Organohalogen Compounds, 29, 316-319.
109. Hallgren, S. and Darnerud, P. O. (1998) Ef- fects of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and chlorinated paraffins (CPs) on thyroid hormone levels and enzyme activities in rats. Organohalogen Com- pounds, 35, 391-394.
110. Fowles, J. R., Fairbrother, A., Beacher-Steppan, L. and Kervliet, N. I. (1994) Immunologic and endocrine effects of the flame-retardant pentabro- modiphenyl ether (DE-71) in C57BL/6J mice. Tox- icology, 86, 49-61.
111. IPCS (1994) Environmental Health Criteria 162: Brominated diphenyl ethers, International Pro- gramme on Chemical Safety, World Health Organization, Geneva, http://www.inchem.org /documents/ehc/ehc/ehc162.htm
112. Zhou, T., Ross, D. J., DeVito, M J. and Crofton, K. M. (2001) Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol. Sci., 61, 76-82.
113. Zhou, T., Taylor, M. M., DeVito, M. J. and Crofton, K. M. (2002) Developmental exposure to brominated diphenyl ethers results in thyroid hor- mone disruption. Toxicol. Sci., 66, 105-116.
114. Hallgren, S., Sinjari, T., HÅkansson, H. and Darnerud, P. O. (2001) Effects of polybromi-nated diphenyl ethers (PBDEs) and polychlori- nated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch. Toxicol., 75, 200-208.
115. Hallgren, S. and Darnerud, P. O. (2002) Poly- brominated diphenyl ethers (PBDEs), polychlori- nated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects. Toxicology, 177, 227-243.
116. Chengelis, C. P. (2001) A 90-day oral (gavage) tox- icity study of HBCD in rats, WIL-186012, Wil Re- seach Laboratories, Ashland, OH, U. S. A., 1527.
117. Byrne, J. J., Carbone, J. P. and Hanson, E. A. (1987) Hypothyroidism and abnormalities in the kinetics of thyroid hormone metabolism in rats treated chronically with polychlorinated biphenyl and polybrominated biphenyl. Endocrinology, 121, 520-527.
118. Werner, P. R. and Sleight, S. D. (1981) Toxicosis in sows and their pigs caused by feeding rations containing polybrominated biphenyls to sows dur- ing pregnancy and lactation. Am. J. Vet. Res., 42, 183-188.
119. Kitamura, S., Kato, T., Iida, M., Jinno, N., Suzuki, T., Ohta, S., Fujimoto, N., Hanada, H., Kashiwagi, K. and Kashiwagi, A. (2005) Anti-thyroid hor- monal activity of tetrabromobisphenol A, a flame retardant, and related compounds: affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis. Life Sci., 76, 1589-1601.
120. Veldhoen, N., Boggs, A., Walzak, K. and Helbing, C. C. (2006) Exposure to tetrabromobisphenol-A alters TH-associated gene expression and tadpole metamorphosis in the Pacific tree frog Pseudacris regilla. Aquat. Toxicol., 78, 292-302.
121. Swarup, D., Naresh, R., Varshney, V. P., Balagangatharathilagar, M., Kumar, P., Nandi, D. and Patra, R. C. (2007) Changes in plasma hor- mones profile and liver function in cows naturally exposed to lead and cadmium around different in- dustrial areas. Res. Vet. Sci., 82, 16-21.
122. Telisman, S., Cvitkovíc, P., Jurasovíc, J., Pizent, A., Gavella, M. and Rocíc, B. (2000) Semen qual- ity and reproductive endocrine function in relation to biomarkers of lead, cadmium, zinc, and copper in men. Environ. Health Perspect., 108, 45-53.
123. IARC (1994) Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry. In IARC Monographs on the Evaluation of Carcino- genic Risks to Humans, Vol. 58, International Agency for Research on Cancer, Lyon, 1-444.
124. Wade, M. G., Parent, S., Finnson, K. W., Foster, W., Younglai, E., McMahon, A., Cyr, D. G. and Hughes, C. (2002) Thyroid toxicity due to sub- chronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium. Toxicol. Sci., 67, 207-218.
125. Gupta, P. and Kar, A. (1998) Role of ascorbic acid in cadmium-induced thyroid dysfunction and lipid peroxidation. J. Appl. Toxicol., 18, 317-320.
126. Yoshizuka, M., Mori, N., Hamasaki, K., Tanaka, I., Yokoyama, M., Hara, K., Doi, Y., Umezu, Y., Araki, H., Sakamoto, Y., Miyazaki, M. and Fujimoto, S. (1991) Cadmium toxicity in the thy- roid gland of pregnant rats. Exp. Mol. Pathol., 55, 97-104.
127. Baránski, B. (1984) Behavioral alterations in off- spring of female rats repeatedly exposed to cad- mium oxide by inhalation. Toxicol. Lett., 22, 53-61.
128. Kashiwagi, K. and Kashiwagi, A. (2001) Effects of cadmium chloride on amphibians. Zoological Sci- ence, 18 (Suppl.), 30.
129. Schettler, T. (2006) Human exposure to phthalates via consumer products. Int. J. Androl., 29, 134-139.
130. Sathyanarayana, S. (2008) Phthalates and chil- dren's health. Curr. Probl. Pediatr. Adolesc. Health Care, 38, 34-49.
131. Chou, K. and Wright, R. O. (2006) Phthalates in food and medical devices. Journal of Medical Tox- icology, 2, 126-135.
132. Sørensen, L. K. (2006) Determination of phthalates in milk and milk products by liquid chromatog- raphy/tandem mass spectrometry. Rapid Commun. Mass Spectrom., 20, 1135-1143.
133. Zhu, J., Phillips, S. P., Feng, Y. L. and Yang, X. (2006) Phthalate esters in human milk: concen- tration variations over a 6-month postpartum time. Environ. Sci. Technol., 40, 5276-5281.
134. Wenzel, A., Franz, C., Breous, E. and Loos, U. (2005) Modulation of iodide uptake by dialkyl ph- thalate plasticisers in FRTL-5 rat thyroid follicular cells. Mol. Cell. Endocrinol., 244, 63-71.
135. Hinton, R. H., Mitchell, F. E., Mann, A., Chescoe, D., Price, S. C., Nunn, A., Grasso, P. and Bridges, J. W. (1986) Effects of phthalic acid esters on the liver and thyroid. Environ. Health Perspect., 70, 195-210.
136. Price, S. C., Chescoe, D., Grasso, P., Wright, M. and Hinton, R. H. (1988) Alterations in the thy- roids of rats treated for long periods with di- (2-ethylhexyl) phthalate or with hypolipidaemic agents. Toxicol. Lett., 40, 37-46.
137. Poon, R., Lecavalier, P., Mueller, R., Valli, V. E., Procter, B. G. and Chu, I. (1997) Subchronic oral toxicity of di-n-octyl phthalate and di (2-ethylhexyl) phthalate in the rat. Food Chem. Tox- icol., 35, 225-239.
138. Howarth, J. A., Price, S. C., Dobrota, M., Kentish, P. A. and Hinton, R. H. (2001) Effects on male rats of di- (2-ethylhexyl) phthalate and di-n- hexylphthalate administered alone or in combina- tion. Toxicol. Lett., 121, 35-43.
139. Gayathri, N. S., Dhanya, C. R., Indu, A. R. and Kurup, P. A. (2004) Changes in some hormones by low doses of di (2-ethyl hexyl) phthalate (DEHP), acommonly usedplasticizer in PVC blood storage bags and medical tubing. Indian J. Med. Res., 119, 139-144.
140. O'Connor, J. C., Frame, S. R. and Ladics, G. S. (2002) Evaluation of a 15-day screening assay us- ing intact male rats for identifying antiandrogens. Toxicol. Sci., 69, 92-108.
141. Meeker, J. D., Calafat A. M. and Hauser, R. (2007) Di (2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men. Environ. Health Perspect., 115, 1029-1034.
142. Huang, P.- C., Kuo, P.- L., Guo, Y.- L., Liao, P.-C. and Lee, C.-C. (2007) Associations between uri- nary phthalate monoesters and thyroid hormones in pregnant women. Hum. Reprod., 22, 2715-2722.
143. OECD (2008) The Amphibian Metamorphosis As- say, Organisation for Economic Co-operation and Development (OECD) Guideline for the Test- ing of Chemicals, http://www.oecd.org/dataoecd /44/52/40909207.pdf