IP receptor agonist-induced dna synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of endogenous transforming growth factor-α

Journal of Pharmacological Sciences

Volumn 109, Issue 4, 2009, Pages 618-629

  Kimura, Mitsutoshi ^a   Okamoto, Hiroshi ^a   Natsume, Hideshi ^a   Ogihara, Masahiko ^a  

^a JOSAI UNIVERSITY   (Japan)

Author keywords

DNA synthesis; Proliferation (cultured hepatocyte); Prostaglandin I 2; Signal transduction; Transforming growth factor a

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CARBACYCLIN; CAY 10441; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOCLONAL ANTIBODY; PROSTACYCLIN; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; PROTEIN TYROSINE KINASE; RAPAMYCIN; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOCRINE EFFECT; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME PHOSPHORYLATION; LIVER CELL; LIVER PARENCHYMA; MALE; MITOGENESIS; NONHUMAN; RAT; SIGNAL TRANSDUCTION;

EID: 66249106353     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08338FP     Document Type: Article

References (44)

1. Coleman RA, Smith WL, Narumiya S. VIII. International union of pharmacology classification of prostanoid receptors: Properties distribution, and structure of the receptors and their subtype. Pharmacol Rev. 1994;46:205-229.
2. Skouteris GG, Ord MG, Stocken LA. Regulation of the proliferation of primary rat hepatocytes by eicosanoids. J Cell Physiol. 1988;135:516-520.
3. Callery MP, Mangino MJ, Flye MW. Kupffer cell prostaglandin E production is amplified during hepatic regeneration. Hepatology. 1991;14:368-372.
4. Tsujii H, Okamoto Y, Kikuchi E, MatsumotoM, Nakano H. Prostaglandin E2 and liver regeneration. Gastroenterology. 1993;105:495-499.
5. Diehl AM, Rai RM. Regulation of signal transduction during liver regeneration. FASEB J. 1996;10:215-227.
6. Hashimoto N, Watanabe T, Ikeda Y, Yamada H, Taniguchi S, Mitsui H, et al. Prostaglandins induce proliferation of rat hepatocytes through a prostaglandin E2 receptor EP3 subtype. Am J Physiol. 1997;272:G597-G604.
7. Kimura M, Osumi S, Ogihara M. Stimulation of DNA synthesis and proliferation by prostaglandins in primary cultures of adult rat hepatocytes. Eur J Pharmacol. 2000;404:259-271.
8. Michalopoulos GK. Control mechanisms of liver regeneration. J Gastroenterol. 1994;29:23-29.
9. Michalopoulos GK, DeFrances MC. Liver regeneration. Science. 1997;276:60-66.
10. Moncada S. Biological importance of prostacyclin. Br J Pharmacol. 1982;76:3-31.
11. Coleman RA, Humphrey PPA, Kennedy I, Levy GP, Lumley P. Comparisons of the actions of U-46619, a stable prostaglandin H2 analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. Br J Pharmacol. 1981;73:773-778.
12. Garrity MJ, Westcott KR, Eggerman TL, Andersen NH, Storm DR, Robertson RP. Interrelationship between PGE1 and PGI2 binding and stimulation of adenylate cyclase. Am J Physiol. 1983;244:E367-372.
13. Funk CD, Furci L, FritzGerald GA, Grygorczyk R, Rochette C, Bayne MA, et al. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J Biol Chem. 1993;268:26767-26772.
14. Narumiya S, Ichikawa A. Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor. J Biol Chem. 1993;268:20175-20178.
15. Namba T, Oida H, Sugimoto Y, Kakizuka A, Negishi M, Ichikawa A, et al. cDNA cloning of a mouse prostacyclin receptor; multiple signalling pathways and expression in thymic medulla. J Biol Chem. 1994;269:9986-9992.
16. Seglen PO. Preparation of isolated liver cells. Methods Cell Biol. 1975;13:29-83.
17. Kimura M, Ogihara M. Density-dependent proliferation of adult rat hepatocytes in primary culture induced by epidermal growth factor is potentiated by cAMP-elevating agents. Eur J Pharmacol. 1997;324:267-276.
18. Morley CGD, Kingdon, HS. Use of 3H-thymidine for measurement of DNA synthesis in rat liver- a warning. Anal Biochem. 1972;45:298-305.
19. Lee MB, Paxman S. Modification of the Lowry procedure for the analysis of proteolipid protein. Anal Biochem. 1972;47:184-192.
20. Nakamura T, Tomita Y, Ichihara A. Density-dependent growth control of adult rat hepatocytes in primary culture. J Biochem. 1983;94:1029-1035.
21. Kimura M, Ogihara M. Proliferation of adult rat hepatocytes by hepatocyte growth factor is potentiated by both phenylephrine and metaproterenol. J Pharmacol Exp Ther. 1997;282:1146-1154.
22. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227: 680-685.
23. Twobin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheet: procedure and some applications. Proc Natl Acad Sci U S A. 1979;76:4350-4354.
24. Kimura M, Osumi S, Ogihara M. Prostaglandin E2 (EP1) receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of TGF-a. Endocrinology. 2001;142:4428-4440.
25. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem. 1991;266:15771-15781.
26. Szabo E, Qui Y, Baksh S, Michalak M, Opas M. Calreticulin inhibits commitment to adipocyte differentiation. J Cell Biol. 2008;182:103-116.
27. Hillinan EA, Stapelfeld A, Savage MA, Reichman M. 8-Chlorodibenz[B,F][1, 4]oxazepine-10(11H)-carboxylic acid, 2-[3-[2-(furanylmethyl)thio]-1-oxopropyl] hydrazide (SC-51322): a potent PGE2 antagonist and analgesic. Bioorg Med Chem Lett. 1994;4:509-514.
28. Lawrence RA, Jones RL, Wilson NH. Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea pig ileum. Br J Pharmacol. 1992;105:271-278.
29. Vassaux G, Gaillard D, Ailhaud G, Negrei R. Prostacyclin is a specific effector of adipose cell differentiation. J Biol Chem. 1992;267:11092-11097.
30. Thompson AK, Mostafapour SP, Denlinger LC, Blesadale JE, Fisher SK. The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-NSH neuroblastoma cells. J Biol Chem. 1991;266:23856-23862.
31. Striggow F, Bohnensack R. Verapamil and diltiazem inhibit receptor-operated calcium channels and intracellular calcium oscillations in rat hepatocytes. FEBS Lett. 1993;318:341-344.
32. Holgate ST, Lewis RA, Austen KF. Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose-modified adenosine analogs. Proc Natl Acad Sci U S A. 1980;77:6800-6804.
33. Zusick MJ, Puzas JE, Rosier RN, Gunter KK, Gunter TE. Cyclic-AMP-dependent protein kinase activity is not required by parathyroid hormone to stimulate phosphoinositide signaling in chondrocytes but is required to transduce the hormone's proliferative effect. Arch Biochem Biophys. 1994;315:352-361.
34. Levitzki A, Gazit A. Tyrosine kinase inhibition: an approach to drug development. Science. 1995;267:1782-1788.
35. Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem. 1994;269: 5241-5248.
36. Alessi D, Cuenda A, Cohen P, Dudley D, Staltiel A. PD098059 is a specific inhibitor of the activation of MAP kinase kinase-1 in vitro and in vivo. J Biol Chem. 1995;270:27489-27494.
37. Price DJ, Grove JR, Calvo V, Avruch J, Bierer BE. Rapamycininduced inhibition of the 70-kilodalton S6 protein kinase. Science. 1992;257:973-977.
38. Ullrich A, Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell. 1990;61:203-212.
39. Davis RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem. 1993;268:14553-14556.
40. Xiaomei LPG, Zamarripa JL, Brown SES, Wieder ED, Nakamura T, Guzelian PS, et al. Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes. Hepatology. 1995;22:1296-1303.
41. Michalopoulos GK. Liver regeneration; molecular mechanisms of growth control. FASEB J. 1990;4:176-187.
42. Andus T, Bauer J, Gerok W. Effects of cytokines on the liver. Hepatology. 1991;13:364-375.
43. Kimura M, Ogihara M. Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Eur J Pharmacol. 1998;354:271-281.
44. Kimura M, Ogihara M. Stimulation by transforming growth factor-a of DNA synthesis and proliferation of adult rat hepatocytes in primary cultures: modulation by α- and β-adrenoceptor agonist. J Pharmacol Exp Ther. 1999;291:171-180.