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Volumn 13, Issue 3, 2009, Pages 525-534

Practical, highly convergent, asymmetric synthesis of a selective PPARγ modulator

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EID: 66249101202     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op8002882     Document Type: Article
Times cited : (29)

References (51)
  • 2
    • 0033779728 scopus 로고    scopus 로고
    • Reviews on PPARg and insulin resistance: (a) Olefsky, J. M.; Saltiel, A. R. Trends Endocrinol. Metab. 2000, 11, 362-368.
    • Reviews on PPARg and insulin resistance: (a) Olefsky, J. M.; Saltiel, A. R. Trends Endocrinol. Metab. 2000, 11, 362-368.
  • 21
    • 66249087154 scopus 로고    scopus 로고
    • Hydrazine 11 and (S)-ethyl butyrate were not readily available in bulk quantities at the time of this work.
    • Hydrazine 11 and (S)-ethyl butyrate were not readily available in bulk quantities at the time of this work.
  • 27
    • 66249110557 scopus 로고
    • Houlihan, W. J, Ed, Wiley-Interscience: New York, Chapter 2
    • Brown, R. K. In Indoles; Houlihan, W. J., Ed.; Wiley-Interscience: New York, 1972; Part 1, Chapter 2.
    • (1972) Indoles , Issue.PART 1
    • Brown, R.K.1
  • 28
    • 66249091819 scopus 로고    scopus 로고
    • Coleman, N. A. Organic Syntheses; Wiley & Sons: New York, 1948; Collect. 1, pp 442-445.
    • Coleman, N. A. Organic Syntheses; Wiley & Sons: New York, 1948; Collect. Vol. 1, pp 442-445.
  • 42
    • 66249131531 scopus 로고    scopus 로고
    • The low temperature for crystallization was required due to the low melting point of 27.
    • The low temperature for crystallization was required due to the low melting point of 27.
  • 50
    • 66249140121 scopus 로고    scopus 로고
    • The use of higher concentrations of substrates 33 and 34 in the presence of acid resulted in substantial polymerization to polyester-type products.
    • The use of higher concentrations of substrates 33 and 34 in the presence of acid resulted in substantial polymerization to polyester-type products.
  • 51
    • 66249119903 scopus 로고    scopus 로고
    • Optical purity of 9 was 93% starting from 10 at 94% ee.
    • Optical purity of 9 was 93% starting from 10 at 94% ee.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.