Molecular investigations of Rickettsia helvetica infection in dogs, foxes, humans, and Ixodes ticks

Applied and Environmental Microbiology

Volumn 75, Issue 10, 2009, Pages 3230-3237

  Boretti, Felicitas S ^a   Perreten, Andrea ^a   Meli, Marina L ^a   Cattori, Valentino ^a   Willi, Barbara ^a   Wengi, Nicole ^a   Hornok, Sándor ^b   Honegger, Hanspeter ^c   Hegglin, Daniel ^a   Woelfel, Roman ^d   Reusch, Claudia E ^a   Lutz, Hans ^a   Hofmann Lehmann, Regina ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b SZENT ISTVÁN UNIVERSITY   (Hungary)

^c TRIEMLI HOSPITAL   (Switzerland)

^d BUNDESWEHR INSTITUTE OF MICROBIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; GENES; MAMMALS; POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RNA; VIRUSES;

BLOOD SAMPLES; CITRATE SYNTHASE; EXPOSED TO; HUMAN PATIENTS; LIKELIHOOD ESTIMATE; POTENTIAL EXPOSURE; RRNA GENES; SWITZERLAND;

BLOOD;

CITRATE SYNTHASE; RNA 23S;

BACTERIAL DISEASE; BACTERIUM; BIOASSAY; BLOOD; GENETIC ANALYSIS; INFECTIOUS DISEASE; MAMMAL; MOLECULAR ANALYSIS; PATHOGEN; POLYMERASE CHAIN REACTION; RNA;

ARTICLE; BLOOD SAMPLING; CAT; CONTROLLED STUDY; DOG; ENVIRONMENTAL EXPOSURE; FOX; HOST RANGE; INFECTION RISK; IXODES; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE PREVALENCE; PARASITE VECTOR; PHYLOGENY; PREVALENCE; REAL TIME POLYMERASE CHAIN REACTION; RICKETTSIA; RICKETTSIA HELVETICA; RICKETTSIA MONACENSIS; RICKETTSIACEAE INFECTION; RNA SEQUENCE;

ANIMALIA; CANIDAE; CANIS FAMILIARIS; IXODES; IXODIDA; MAMMALIA; RICKETTSIA HELVETICA; RICKETTSIA MONACENSIS; RICKETTSIACEAE; TICK-BORNE ENCEPHALITIS VIRUS;

EID: 66249091975     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.00220-09     Document Type: Article

References (42)

1. Baumann, D., N. Pusterla, O. Peter, F. Grimm, P. E. Fournier, G. Schar, W. Bossart, H. Lutz, and R. Weber. 2003. Fever after a tick bite: clinical manifestations and diagnosis of acute tick bite-associated infections in northeastern Switzerland. Dtsch. Med. Wochenschr. 128:1042-1047. (In German.)
2. Beninati, T., N. Lo, H. Noda, F. Esposito, A. Rizzoli, G. Favia, and C. Genchi. 2002. First detection of spotted fever group rickettsiae in Ixodes ricinus from Italy. Emerg. Infect. Dis. 8:983-986.
3. Blanco, J. R., and J. A. Oteo. 2006. Rickettsiosis in Europe. Ann. N. Y. Acad. Sci. 1078:26-33.
4. Bland, M. 2000. An introduction to medical statistics. Oxford University Press, Oxford, United Kingdom.
5. Breitschwerdt, E. B., D. H. Walker, M. G. Levy, W. Burgdorfer, W. T. Corbett, S. A. Hurlbert, M. E. Stebbins, B. C. Curtis, and D. A. Allen. 1988. Clinical, hematologic, and humoral immune response in female dogs inoculated with Rickettsia rickettsii and Rickettsia montana. Am. J. Vet. Res. 49:70-76.
6. Cotty, A. 1985. Clé de determination des Ixodidae et Amblyommidae de Suisse. Institut de Zoologie, Université de Neuchâtel, Neuchâtel, Switzerland.
7. Fournier, P. E., C. Allombert, Y. Supputamongkol, G. Caruso, P. Brouqui, and D. Raoult. 2004. An eruptive fever associated with antibodies to Rickettsia helvetica in Europe and Thailand. J. Clin. Microbiol. 42:816-818.
8. Fournier, P. E., F. Grunnenberger, B. Jaulhac, G. Gastinger, and D. Raoult. 2000. Evidence of Rickettsia helvetica infection in humans, eastern France. Emerg. Infect. Dis. 6:389-392.
9. Hartelt, K., R. Oehme, H. Frank, S. O. Brockmann, D. Hassler, and P. Kimmig. 2004. Pathogens and symbionts in ticks: prevalence of Anaplasma phagocytophilum (Ehrlichia sp.), Wolbachia sp., Rickettsia sp., and Babesia sp. in southern Germany. Int. J. Med. Microbiol. 293(Suppl. 37):86-92.
10. Inokuma, H., N. Seino, M. Suzuki, K. Kaji, H. Takahashi, H. Igota, and S. Inoue.2008. Detection of Rickettsia helvetica DNA from peripheral blood of sika deer (Cervus nippon yesoensis) in Japan. J. Wildl. Dis. 44:164-167.
11. Kaplowitz, L. G., J. V. Lange, J. J. Fischer, and D. H. Walker. 1983. Correlation of rickettsial titers, circulating endotoxin, and clinical features in Rocky Mountain spotted fever. Arch. Intern. Med. 143:1149-1151.
12. Kidd, L., R. Maggi, P. P. Diniz, B. Hegarty, M. Tucker, and E. Breitschwerdt. 2008. Evaluation of conventional and real-time PCR assays for detection and differentiation of spotted fever group Rickettsia in dog blood. Vet. Micro- biol. 129:294-303.
13. Kimura, M. 1980. A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J. Mol. Evol. 16:111-120.
14. Klein, D., P. Janda, R. Steinborn, M. Muller, B. Salmons, and W. H. Gunzburg. 1999. Proviral load determination of different feline immunodeficiency virus isolates using real-time polymerase chain reaction: influence of mismatches on quantification. Electrophoresis 20:291-299.
15. Klein, D., C. M. Leutenegger, C. Bahula, P. Gold, R. Hofmann-Lehmann, B. Salmons, H. Lutz, and W. H. Gunzburg. 2001. Influence of preassay and sequence variations on viral load determination by a multiplex real-time reverse transcriptase-polymerase chain reaction for feline immunodeficiency virus. J. Acquir. Immune Defic. Syndr. 26:8-20.
16. Kumar, S., K. Tamura, and M. Nei. 2004. MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform. 5:150-163.
17. Matthewman, L., P. Kelly, D. Hayter, S. Downie, K. Wray, N. Bryson, A. Rycroft, and D. Raoult. 1997. Domestic cats as indicators of the presence of spotted fever and typhus group rickettsiae. Eur. J. Epidemiol. 13:109-111.
18. Nielsen, H., P. E. Fournier, I. S. Pedersen, H. Krarup, T. Ejlertsen, and D. Raoult. 2004. Serological and molecular evidence of Rickettsia helvetica in Denmark. Scand. J. Infect. Dis. 36:559-563.
19. Nilsson, K., O. Lindquist, A. J. Liu, T. G. Jaenson, G. Friman, and C. Pahlson. 1999. Rickettsia helvetica in Ixodes ricinus ticks in Sweden. J. Clin. Microbiol. 37:400-403.
20. Nilsson, K., O. Lindquist, and C. Pahlson. 1999. Association of Rickettsia helvetica with chronic perimyocarditis in sudden cardiac death. Lancet 354:1169-1173.
21. Nilsson, K., A. Liu, C. Pahlson, and O. Lindquist. 2005. Demonstration of intracellular microorganisms (Rickettsia spp., Chlamydia pneumoniae, Bar- tonella spp.) in pathological human aortic valves by PCR. J. Infect. 50:46-52.
22. Nilsson, K., A. Lukinius, C. Pahlson, C. Moron, N. Hajem, B. Olsson, and O. Lindquist. 2005. Evidence of Rickettsia spp. infection in Sweden: a clinical, ultrastructural and serological study. APMIS 113:126-134.
23. Norment, B. R., and W. Burgdorfer. 1984. Susceptibility and reservoir potential of the dog to spotted fever-group rickettsiae. Am. J. Vet. Res. 45:1706-1710.
24. O'Brien, D., S. Tobin, G. V. Brown, and J. Torresi. 2001. Fever in returned travelers: review of hospital admissions for a 3-year period. Clin. Infect. Dis. 33:603-609.
25. Parola, P., L. Beati, M. Cambon, and D. Raoult. 1998. First isolation of Rickettsia helvetica from Ixodes ricinus ticks in France. Eur. J. Clin. Micro- biol. Infect. Dis. 17:95-100.
26. Parola, P., C. D. Paddock, and D. Raoult. 2005. Tick-borne rickettsioses around the world: emerging diseases challenging old concepts. Clin. Micro- biol. Rev. 18:719-756.
27. Roux, V., E. Rydkina, M. Eremeeva, and D. Raoult. 1997. Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae. Int. J. Syst. Bacteriol. 47:252-261.
28. Saitou, N., and M. Nei. 1987. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol. Biol. Evol. 4:406-425.
29. Santos-Silva, M. M., R. Sousa, A. S. Santos, P. Melo, V. Encarnacao, and F. Bacellar. 2006. Ticks parasitizing wild birds in Portugal: detection of Rick- ettsia aeschlimannii, R. helvetica and R. massiliae. Exp. Appl. Acarol. 39:331-338.
30. Sekeyova, Z., P. E. Fournier, J. Rehacek, and D. Raoult. 2000. Characterization of a new spotted fever group rickettsia detected in Ixodes ricinus (Acari: Ixodidae) collected in Slovakia. J. Med. Entomol. 37:707-713.
31. Sieber-Ruckstuhl, N. S., M. L. Meli, F. S. Boretti, E. Gonczi, H. Lutz, and C. E. Reusch. 2007. Quantitative real-time PCR for the measurement of 11 β-HSD1 and 11 β-HSD2 mRNA levels in tissues of healthy dogs. Hormone Metab. Res. 39:548-554.
32. Skarphedinsson, S., P. M. Jensen, and K. Kristiansen. 2005. Survey of tickborne infections in Denmark. Emerg. Infect. Dis. 11:1055-1061.
33. Skarphedinsson, S., B. F. Lyholm, M. Ljungberg, P. Sogaard, H. J. Kolmos, and L. P. Nielsen. 2007. Detection and identification of Anaplasma phago- cytophilum, Borrelia burgdorferi, and Rickettsia helvetica in Danish Ixodes ricinus ticks. APMIS 115:225-230.
34. Sreter, T., Z. Sreterne Lancz, Z. Szell, and L. Egyed. 2005. Rickettsia helvetica: an emerging tick-borne pathogen in Hungary and Europe. Orv. Hetil. 146:2547-2552. (In Hungarian.)
35. Stanczak, J. 2006. The occurrence of spotted fever group (SFG) rickettsiae in Ixodes ricinus ticks (Acari: Ixodidae) in northern Poland. Ann. N. Y. Acad. Sci. 1078:512-514.
36. Stenos, J., S. R. Graves, and N. B. Unsworth. 2005. A highly sensitive and specific real-time PCR assay for the detection of spotted fever and typhus group Rickettsiae. Am. J. Trop. Med. Hyg. 73:1083-1085.
37. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
38. Wengi, N., B. Willi, F. S. Boretti, V. Cattori, B. Riond, M. L. Meli, C. E. Reusch, H. Lutz, and R. Hofmann-Lehmann. 2008. Real-time PCR- based prevalence study, infection follow-up and molecular characterization of canine hemotropic mycoplasmas. Vet. Microbiol. 126:132-141.
39. Wicki, R., P. Sauter, C. Mettler, A. Natsch, T. Enzler, N. Pusterla, P. Kuhnert, G. Egli, M. Bernasconi, R. Lienhard, H. Lutz, and C. M. Leuteneg- ger. 2000. Swiss army survey in Switzerland to determine the prevalence of Francisella tularensis, members of the Ehrlichia phagocytophila genogroup, Borrelia burgdorferi sensu lato, and tick-borne encephalitis virus in ticks. Eur. J. Clin. Microbiol. Infect. Dis. 19:427-432.
40. Willi, B., F. S. Boretti, M. L. Meli, M. V. Bernasconi, S. Casati, D. Hegglin, M. Puorger, H. Neimark, V. Cattori, N. Wengi, C. E. Reusch, H. Lutz, and R. Hofmann-Lehmann. 2007. Real-time PCR investigation of potential vectors, reservoirs, and shedding patterns of feline hemotropic mycoplasmas. Appl. Environ. Microbiol. 73:3798-3802.
41. Williams, C. J. 2005. Estimation of pathogen prevalence in pooled samples using maximum likelihood methods and open-source software. J. Aquat. Anim. Health 17:386-391.
42. Wolfel, R., R. Terzioglu, J. Kiessling, S. Wilhelm, S. Essbauer, M. Pfeffer, and G. Dobler. 2006. Rickettsia spp. in Ixodes ricinus ticks in Bavaria, Germany. Ann. N. Y. Acad. Sci. 1078:509-511.