A MEMS based handheld confocal microscope with Raman spectroscopy for in-vivo skin cancer diagnosis

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 7169, Issue , 2009, Pages

  Arrasmith, Christopher L ^a   Patil, Chetan A ^b   Dickensheets, David L ^a   Mahadevan Jansen, Anita ^b  

^a Montana State University   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Confocal microscopy; Diagnosis; Laser; MEMS; Raman spectroscopy; Skin cancer

Indexed keywords

AXIAL RESOLUTIONS; CLINICAL SETTINGS; COMPACT DESIGNS; CONFOCAL MICROSCOPES; HANDHELD; ILLUMINATION LASERS; IN-VIVO; IN-VIVO IMAGES; INSTRUMENT DESIGNS; MEMS MIRRORS; NORMAL SKIN; OPTICAL CHARACTERISTICS; RAMAN CHANNEL; RAMAN DATA; RAMAN SPECTRA; REFLECTANCE IMAGES; REFLECTANCE IMAGING; SKIN CANCER; SKIN CANCERS; SKIN SURFACES; TWO-DIMENSION;

BAYESIAN NETWORKS; CHARGE COUPLED DEVICES; CONFOCAL MICROSCOPY; LASERS; MEMS; MICROELECTROMECHANICAL DEVICES; MICROSCOPES; MIRRORS; PROBES; RAMAN SCATTERING; RAMAN SPECTROSCOPY; REFLECTION; SPECTRUM ANALYSIS;

SKIN;

EID: 66249084162     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.812071     Document Type: Conference Paper

References (16)

1. A. Jemal and e. al., "Cancer statistics," CA: A cancer journal for clinicians, vol. 57, pp. 43-66, September 2007.
2. M. Rajadhyaksha, S. Gonzalez, J. M. Zavislan, R. R. Anderson, and R. H. Webb, "In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology," Journal of Investigative Dermatology, vol. 113, no. 3, pp. 293-303, September 1999.
3. P. J. Caspers, G. W. Lucassen, and G. J. Puppels, "Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin," Biophysical Journal, vol. 85, pp. 572-580, July 2003.
4. M. Rajadhyaksha, M. Grossman, D. Esterowitz, R. H. Webb, and R. R. Anderson, "In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast," Journal of Investigative Dermatology, vol. 104, no. 6, pp. 946-952, June 1995.
5. B. R. Masters and P. T. C. So, "Confocal microscopy and multi-photon excitation microscopy of human skin in vivo," Optics Express, vol. 8, no. 1, January 2001.
6. P. Corcuff and J. L. Leveque, "In vivo vision of human skin with tandem scanning microscope," Dermatology, vol. 186, pp. 50-54, 1993.
7. Z. Tannous, A. Torres, and S. Gonzalez, "In vivo real-time confocal reflectance microscopye: a noninvasive guide for Mohs micrograph surgery facilitated by aluminum chloride, and excellent contrast enhancer," Dermatologic Surgery, vol. 29, no. 8, pp. 839-846, August 2003.
8. C.-S. J. Chen, M. Elias, K. Busam, M. Rajadhyaksha, and A. A. Marghoob, "Multimodal in vivo optical imaging, including confocal microscopy, facilitates presurgical margin mapping for a clinically complex lentigo maligna melanoma," British Journal of Dermatology, vol. 153, pp. 1031-1036, 2005.
9. K. Carlson et al., "In vivo fiber-optic confocal reflectance microscope with an injection-molded plastic miniature objective lens," Applied Optics, vol. 44, no. 10, pp. 1792-1797, April 2005.
10. H.-J. Shin et al., "Fiber-optic confocal microscope using a MEMS scanner and miniature objective lens," Optics Express, vol. 15, no. 15, July 2007.
11. P. J. Caspers, G. W. Lucassen, E. A. Carter, H. A. Bruining, and G. J. Puppels, "In vivo confocal reflectance microspectroscopy of the skin: noninvasive determination of molecular concentration profiles," The journal of investigative dermatology, vol. 116, no. 3, pp. 434-442, March 2001.
12. S. Sigurdsson et al., "Detection of skin cancer by classification of Raman spectra," IEEE transactions on biomedical engineering, 2004.
13. C. A. Lieber, D. L. Ellis, D. D. Billheimer, and A. Mahadevan-Jansen, "Handheld confocal Raman microspectrometer for in-vivo skin cancer measurement," in Biomedical Vibrational Spectroscopy/Biohazard Detection Technologies, Bellingham, WA, 2004, pp. 10-16.
14. P. C. D. Hobbs, Building electro-optical systems: making it all work. United States of America: Wiley & Sons, Inc., 2000.
15. M. Gu, C. J. R. Sheppard, and X. Gan, "Image formation in a fiber-optical confocal scanning microscope," Journal of the Optical Society of America, vol. 8, no. 11, pp. 1755-1761, November 1991.
16. C. L Arrasmith, "A combined confocal imaging and Raman spectroscopy microscope for in vivo skin cancer diagnosis," Montana State University, Master's Thesis 2009.