Scalable non-aqueous process to prepare water soluble 3-amino-pentan-1,5- diol

Organic Process Research and Development

Volumn 13, Issue 3, 2009, Pages 478-482

  Rawalpally, Thimma ^a   Ji, Yaohui ^a   Cleary, Thomas ^a   Edwards, Billy ^a  

^a Roche Carolina   (United States)

Author keywords

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Indexed keywords

EID: 66249084149     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op800245v     Document Type: Article

References (11)

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5. Tomori, H.; Hibutani, K.; Ogura, K. Heterocycles 1997, 44, 213.
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7. The bulk commercial cost of TBAB is $220/kg ($20/mol).
8. Augustine, R. L.; Bellina, R. L. J. Org. Chem. 1968, 33, 1287.
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10. For a similar approach to this problem, see: Zhu, W.; Ma, D. Org. Lett. 2003, 26, 5063.
11. Cleary, T.; Ji, Y.; Lee, L.; Rawalpally, T.; Sarma, K. PCT Int. Appl. WO/2008/0151992 A2 20081218, 2008.