Contractility of diabetic human corpus cavernosum smooth muscle in response to serotonin mediated via Rho-kinase

Pharmacology

Volumn 84, Issue 1, 2009, Pages 24-28

  Murat, Nergis ^a   Soner, Burak Cem ^a   Demir, Omer ^a   Esen, Adil ^a   Gidener, Sedef ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

Corpus cavernosum, human; Diabetes mellitus; Rho kinase; Serotonin

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RHO KINASE; RHO KINASE INHIBITOR; SEROTONIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETIC PATIENT; HUMAN; HUMAN TISSUE; MUSCLE CONTRACTILITY; PRIORITY JOURNAL; SMOOTH MUSCLE;

AMIDES; DIABETES MELLITUS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOMETRIC CONTRACTION; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; PENIS; PYRIDINES; RHO-ASSOCIATED KINASES; SEROTONIN;

EID: 66149158521     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000221380     Document Type: Article

References (19)

1. Aversa A, Bruzziches R, Vitale C, Marazzi G, Francomano D, Barbaro G, Spera G, Rosana GM: Chronic sildenafil in men with diabetes and erectile dysfunction. Expert Opin Drug Metab Toxicol 2007; 3: 451-464. (Pubitemid 47316035)
2. Cameron NE, Cotter MA: Erectile dysfunction and diabetes mellitus: mechanistic considerations from studies in experimental models. Curr Diabetes Rev 2007; 3: 149-158.
3. Uckert S, Fuhlenriede MH, Becker AJ, Stief CG, Scheller F, Knapp WH, Forssmann WG, Jonas U: Is 5-HT significant for the control of penile flaccidity and detumescence in the human male? Urol Res 2003; 31: 55-60.
4. Andersson KE, Wagner G: Physiology of penile erection. Pharmacol Rev 1995; 75: 191-236.
5. Furukawa K, Nagao K, Ishii N, Uchiyama T: Responses to serotonin (5-HT) in isolated corpus cavernosum penis of rabbit. Int J Impot Res 2003; 15: 267-271. (Pubitemid 37101660)
6. Hayes ES, Adaikan PG: The effects of 5HT(1) agonists on erection in rats in vivo and rabbit corpus cavernosum in vitro. Int J Impot Res 2002; 14: 205-212.
7. Lau DH, Thompson CS, Bellringer JF, Thomas PJ, Mumtaz FH, Morgan RJ, et al: Doxazosin and serotonin (5-HT) receptor (1A, 2A, and 4) antagonists inhibit 5-HT-mediated human cavernosal contraction. J Androl 2006; 27: 679-685.
8. Esen AA, Gidener S, Guler C, Guven H, Kirkali Z: Contractility changes of the deep dorsal penile vein due to serotonin. J Urol 1997; 158: 234-237. (Pubitemid 27251632)
9. Kodama M, Takimoto Y: Influence of 5-hydroxytryptamine and the effect of a new serotonin receptor antagonist (sarpogrelate) on detrusor smooth muscle of streptozotocin-induced diabetes mellitus in the rat. Int J Urol 2000; 7: 231-235. (Pubitemid 30330703)
10. Miranda FJ, Alabadí JA, Lloréns S, Ruiz de Apodaca RF, Centeno JM, Alborch E: Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine. Eur J Pharmacol 2002; 439: 121-127. (Pubitemid 34286615)
11. Sikorski BW, James GM, Glance SD, Hodgson WC, King RG: Effect of endothelium on diabetes-induced changes in constrictor responses mediated by 5-hydroxytryptamine in rat aorta. J Cardiovasc Pharmacol 1993; 22: 423-430.
12. Kodama M, Takimoto Y: Influence of 5-hydroxytryptamine and the effect of a new serotonin receptor antagonist (sarpogrelate) on detrusor smooth muscle of streptozotocin- induced diabetes mellitus in the rat. Int J Urol 2000; 7: 231-235. (Pubitemid 30330703)
13. 2+ sensitization in erectile function. J Biol Chem 2002; 277: 30614-30621.
14. Andersson KE: Erectile physiological and pathophysiological pathways involved in erectile dysfunction. J Urol 2003; 170:S6-S13.
15. Tang J, Kusaka I, Massey AR, Rollins S, Zhang JH: Increased RhoA translocation in aorta of diabetic rats. Acta Pharmacol Sin 2006; 27: 543-548.
16. Chang S, Hypolite JA, Changolkar A, Wein AJ, Chacko S, DiSanto ME: Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase beta. Int J Impot Res 2003; 15: 53-62. (Pubitemid 36356359)
17. Andersson KE: Neurophysiology/pharmacology of erection. Int J Impot Res 2001; 13: 8-17.
18. Musicki B, Burnett AL: eNOS function and dysfunction in the penis. Exp Biol Med (Maywood) 2006; 231: 154-165.
19. Moore CR, Wang R: Pathophysiology and treatment of diabetic erectile dysfunction. Asian J Androl 2006; 8: 675-684. (Pubitemid 44869615)