Absence of platelet recovery following Helicobacter pylori eradication in childhood chronic idiopathic thrombocytopenic purpura: A multi-center randomized controlled trial

Pediatric Blood and Cancer

Volumn 53, Issue 1, 2009, Pages 72-77

  Treepongkaruna, Suporn ^a   Sirachainan, Nongnuch ^a   Kanjanapongkul, Somjai ^b   Winaichatsak, Angkana ^c   Sirithorn, Suebsuk ^d   Sumritsopak, Rungtip ^a   Chuansumrit, Ampaiwan ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b QUEEN SIRIKIT NATIONAL INSTITUTE OF CHILD HEALTH   (Thailand)

^c MAHARAT NAKHON RATCHASIMA HOSPITAL   (Thailand)

^d Bhumipol Adulyadej Hospital   (Thailand)

Author keywords

Helicobacter pylori; Idiopathic thrombocytopenic purpura; Platelet; Platelet count

Indexed keywords

AMOXICILLIN; CARBON 13; CLARITHROMYCIN; LANSOPRAZOLE; METRONIDAZOLE; PREDNISOLONE; RANITIDINE BISMUTH CITRATE;

ADOLESCENT; ADULT; ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DEMOGRAPHY; DISEASE DURATION; DOSE RESPONSE; ERADICATION THERAPY; HELICOBACTER INFECTION; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PATIENT MONITORING; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; THROMBOCYTE COUNT; TREATMENT OUTCOME; UREA BREATH TEST; BLOOD; FEMALE; HELICOBACTER PYLORI; MALE; PATHOGENICITY; REMISSION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; PLATELET COUNT; PREDNISOLONE; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; REMISSION INDUCTION;

EID: 66149151011     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.21991     Document Type: Article

References (27)

1. Blanchette VS, Price V. Childhood chronic immune thrombocytopenic purpura: Unresolved issues. J Pediatr Hematol Oncol 2003;25:S28-S33. (Pubitemid 37517915)
2. Blanchette V, Bolton-Maggs P. Childhood immune thrombocytopenic purpura: Diagnosis and management. Pediatr Clin North Am 2008;55:393-420.
3. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002;347:1175-1186.
4. Stasi R, Rossi Z, Stipa E, et al. Helicobacter pylori eradication in the management of patients with idiopathic thrombocytopenic purpura. Am J Med 2005;118:414-419.
5. Gasbarrini A, Franceschi F, Tartaglione R, et al. Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori. Lancet 1998;352:878.
6. Inaba T, Mizuno M, Take S, et al. Eradication of Helicobacter pylori increases platelet count in patients with idiopathic thrombocytopenic purpura in Japan. Eur J Clin Invest 2005;35:214-219.
7. Suzuki T, Matsushima M, Masui A, et al. Effect of Helicobacter pylori eradication in patients with chronic idiopathic thrombocytopenic purpura - A randomized controlled trial. Am J Gastroenterol 2005;100:1265-1270.
8. Veneri D, Krampera M, Franchini M. High prevalence of sustained remission of idiopathic thrombocytopenic purpura after Helicobacter pylori eradication: A long-term folow-up study. Platelets 2005;16:117-119.
9. Rostami N, Keshtkar-Jahromi M, Rahnavardi M, et al. Effect of eradication of Helicobacter pylori on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura: A controlled trial. Am J Hematol 2008;83:376-381.
10. Emilia G, Luppi M, Zucchini P, et al. Helicobacter pylori infection and chronic immune thrombocytopenic purpura: Long-term results of bacterium eradication and association with bacterium virulence profiles. Blood 2007;110:3833-3841.
11. Franchini M, Veneri D. Helicobacter pylori infection and immune thrombocytopenic purpura: An update. Helicobacter 2004;9:342-346.
12. Jackson S, Beck PL, Pineo GF, et al. Helicobacter pylori eradication: Novel therapy for immune thrombocytopenic purpura? A review of the literature. Am J Hematol 2005;78:142-150.
13. Stasi R, Sarpatwari A, Segal JB, et al. Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura. A systematic review. Blood: 2009;113:1231-1240.
14. Takahashi T, Yujiri T, Shinohara K, et al. Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H. pylori-associated chronic idiopathic thrombocytopenic purpura. Br J Haematol 2004;124:91-96.
15. Kodama M, Kitadai Y, Ito M, et al. Immune response to CagA protein is associated with improved platelet count after Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura. Helicobacter 2007;12:36-42.
16. Jaing TH, Yang CP, Hung IJ, et al. Efficacy of Helicobacter pylori eradication on platelet recovery in children with chronic idiopathic thrombocytopenic purpura. Acta Paediatr 2003;92:1153-1157.
17. Hayashi H, Okuda M, Aoyagi N, et al. Helicobacter pylori infection in children with chronic idiopathic thrombocytopenic purpura. Pediatr Int 2005;47:292-295.
18. Bisogno G, Errigo G, Rossetti F, et al. The role of Helicobacter pylori in children with chronic idiopathic thrombocytopenic purpura. J Pediatr Hematol Oncol 2008;30:53-57.
19. Hamidieh AA, Arzanian MT, Gachkar L, et al. Helicobacter pylori infection in children with chronic idiopathic thrombocytopenic purpura. J Pediatr Hematol Oncol 2008;30:96-97.
20. Neefjes VM, Heijboer H, Tamminga RY. H. pylori infection in childhood chronic immune thrombocytopenic purpura. Haematologica 2007;92:576.
21. Treepongkaruna S, Nopchinda S, Taweewongsounton A, et al. A rapid serologic test and immunoblotting for the detection of Helicobacter pylori infection in children. J Trop Pediatr 2006;52:267-271.
22. Rajantie J, Klemola T. Helicobacter pylori and idiopathic thrombocytopenic purpura in children. Blood 2003;101:1660.
23. Everhart JE. Recent development in the epidemiology of Helicobacter pylori. Gastroenterol Clin North Am 2000;29:559-578.
24. Bodhidatta L, Hoge CW, Churnratanakul S, et al. Diagnosis of Helicobacter pylori infection in a developing country: Comparison of two ELISAs and a seroprevalence study. J Infect Dis 1993;168:1549-1553.
25. Vivatvakin B, Theamboonlers A, Semakachorn N, et al. Prevalence of CagA and VacA genotype of Helicobacter pylori in Thai children. J Med Assoc Thai 2004;87:1327-1331.
26. Jarque I, Andreu R, Llopis I, et al. Absence of platelet response after eradication of Helicobacter pylori infection in patients with chronic idiopathic thrombocytopenic purpura. Br J Haematol 2001;115:1002-1003.
27. Michel M, Cooper N, Jean C, et al. Does Helicobater pylori initiate or perpetuate immune thrombocytopenic purpura? Blood 2004;103:890-896.