Mechanical force inhibits osteoclastogenic potential of human periodontal ligament fibroblasts through OPG production and ERK-mediated signaling

Journal of Cellular Biochemistry

Volumn 106, Issue 6, 2009, Pages 1010-1019

  Kook, Sung Ho ^a   Son, Young Ok ^b   Hwang, Jung Min ^a   Kim, Eun Mi ^a   Lee, Choon Bong ^a   Jeon, Young Mi ^a   Kim, Jong Ghee ^a   Lee, Jeong Chae ^a  

^a Chonbuk National University   (South Korea)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Centrifugal force; Extracellular signal regulated kinase; Gingival fibroblasts; Osteoclastogenesis; Osteoprotegerin; Periodontal ligament fibroblasts

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CELL ANTIBODY; COLECALCIFEROL; DEXAMETHASONE; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; OSTEOPROTEGERIN ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CENTRIFUGAL FORCE; CONTROLLED STUDY; FIBROBLAST; FORCE; GINGIVA; HUMAN; HUMAN CELL; OSTEOCLAST; OSTEOCLASTOGENESIS; PERIODONTAL LIGAMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ADULT; BONE MARROW CELLS; BONE REMODELING; BONE RESORPTION; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GINGIVA; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; OSTEOCLASTS; OSTEOPROTEGERIN; PERIODONTAL LIGAMENT; RANK LIGAND; RNA, SMALL INTERFERING; STRESS, MECHANICAL; YOUNG ADULT;

EID: 66149137194     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22086     Document Type: Article

References (32)

1. Berkovitz BK. 1990. The structure of the periodontal ligament: An update. Eur J Orthod 12:51-76. (Pubitemid 20138465)
2. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
3. de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V. 2006. Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts. J Cell Biochem 98:370-382.
4. Hasegawa T, Yoshimura Y, Kikuiri T, Yawaka Y, Takeyama S, Mstsumoto A, Oguchi H, Shirakawa T. 2002. Expression of receptor activator of NF-kappaB ligand and osteoprotegerin in culture of human periodontal ligament cells. J Periodontal Res 37:405-411.
5. Hassel TM, Stanek EJ. 1983. Evidence that healthy human gingival contains functionally heterogeneous fibroblast subpopulations. Arch Oral Biol 28:617-625.
6. Hofbauer LC, Heufelder AE. 2001. The role of osteoprotegerin and osteoprotegerin ligand in the pathogenesis and treatment of metabolic bone diseases. J Clin Endocrinolo Metab 85:2355-2363.
7. Hofbauer LC, Neubauer A, Heufelder AE. 2001. Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin. Cancer 92:460-470.
8. Hormdee D, Nagasawa T, Kiji M, Yashiro R, Kobayashi H, Koshy G, Noguchi K, Nitta H, Ishikawa I. 2005. Protein kinase-A-dependent osteoprotegerin production on interleukin-1 stimulation in human gingival fibroblasts is distinct from periodontal ligament fibroblasts. Clin Exp Immunol 142:490-497.
9. Howard PS, Kucich U, Taliwal R, Korostoff JM. 1998. Mechanical forces alter extracellular matrix synthesis by human periodontal ligament fibroblasts. J Periodontal Res 33:500-508.
10. Iqbal J, Zaidi M. 2005. Molecular regulation of mechanotransduction. Biochem Biophys Res Communi 328:751-755.
11. Jeon YM, Kook SH, Son YO, Kim EM, Park SS, Kim JG, Lee JC. 2009. Role of MAPK in mechanical force-induced up-regulation of type I collagen and osteopontin in human gingival fibroblasts. Mol Cell Biochem 320:45-52.
12. Kanzaki H, Chiba M, Shimizu Y, Mitani H. 2001. Dual regulation of osteoclast differentiation by periodontal ligament cells through RANKL stimulation and OPG inhibition. J Dent Res 80:887-891.
13. Kanzaki H, Chiba M, Shimizu Y, Mitani H. 2002. Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res 17:210-220.
14. Kanzaki H, Chiba M, Sato A, Miyagawa A, Arai K, Nukatsuka S, Mitani H. 2006. Cyclical tensile force on periodontal ligament cells inhibits osteoclastogenesis through OPG induction. J Dent Res 85:457-462.
15. Kletsas D, Basdra E, Papavassiliou AG. 2002. Effect of protein kinase inhibitors on the stretch-elicited c-Fos and c-Jun up-regulation in human PDL osteoblast-like cells. J Cell Physiol 190:313-321.
16. Kondo T, Kitazawa R, Yamaguchi A, Kitazawa S. 2008. Dexamethasone promotes osteoclastogenesis by inhibiting osteoprotegerin through multiple levels. J Cell Biochem 103:335-345.
17. Kook SH, Son YO, Choi KC, Lee HJ, Chung WT, Hwang IH, Lee JC. 2008. Cyclic mechanical stress suppresses myogenic differentiation of adult bovine satellite cells through activation of extracellular signal-regulated kinase. Mol Cell Biochem 309:133-141.
18. Kook SH, Son YO, Choe Y, Kim JH, Jeon YM, Heo JS, Kim JG, Lee JC. in press. Mechanical force augments the anti-osteoclastogenic potential of human gingival fibroblasts in vitro. J Periodontal Res.
19. Lee JC, Lim KT. 2001. Inhibitory effects of the ethanol extract of Ulmus davidiana on apoptosis induced by glucose-glucose oxidase and cytokine production in cultured mouse primary immune cells. J Biochem Mol Biol 34:463-471.
20. Lekic P, McCulloch CA. 1996. Periodontal ligament cell population: The central role of fibroblasts in creating a unique tissue. Anat Rec 245:327-341.
21. Liedert A, Kaspar D, Blakytny R, Claes L, Ignatius A. 2006. Signal transduction pathways involved in mechanotransduction in bone cells. Biochem Biophys Res Communi 349:1-5.
22. Nagasawa T, Kobayashi H, Kiji M, Aramaki M, Mahanonda R, Kojima T, Murakami Y, Saito M, Morotome Y, Ishikawa I. 2002. LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin. Clin Exp Immunol 130:338-344.
23. Nishijima Y, Yamaguchi M, Kojima T, Aihara N, Nakajima R, Kasai K. 2006. Levels of RANKL and OPG in gingival crevicular fluid during orthodontic tooth movement and effect of compression force on releases from periodontal ligament cells in vitro. Orthod Craniofacial Res 9:63-70.
24. Peverali FA, Basdra EK, Papavassiliou AG. 2001. Stretch-mediated activation of selective MAPK subtypes and potentiation of AP-1 binding in human osteoblastic cells. Mol Med 7:68-78.
25. Redlich M, Palmon A, Zaks B, Geremi E, Rayzman S, Shoshan S. 1998. The effect of centrifugal force on the transcription levels of collagen type I and collagnase in cultured canine gingival fibroblasts. Arch Oral Biol 43:313-316.
26. Redlich M, Roos H, Reichenberg E, Zaks B, Mussig D, Baumert U, Golan I, Palmon A. 2004a. Expression of tropoelastin in human periodontal ligament fibroblasts after simulation of orthodontic force. Arch Oral Biol 49:119-124.
27. Redlich M, Roos H, Reichenberg E, Zaks B, Grosskop A, Bar Kana I, Pitaru S, Palmon A. 2004b. The effect of centrifugal force on mRNA levels of collagenase, collagen type-I, tissue inhibitors of metalloproteinases and β-actin in cultured human periodontal ligament fibroblasts. J Periodontal Res 39:27-32.
28. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang M-S, Lüthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ. 1997. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89:309-319.
29. Sodek J, Limeback HF. 1979. Comparison of the rates of synthesis, conversion and maturation of type I and type III collagens in rat periodontal tissues. J Biol Chem 254:10496-10502.
30. Wada N, Maeda H, Tanabe K, Tsuda E, Yano K, Nakamuta H, Akamine A. 2001. Periodontal ligament cells secrete the factor that inhibits osteoclastic differentiation and function: The factor is osteoprotegerin/osteoclastogenesis inhibitory factor. J Periodontal Res 36:56-63.
31. Wada N, Maeda H, Yoshimine Y, Akamine A. 2004. Lipopolysaccharide stimulates expression of osteoprotegerin and receptor activator of NFkappaB ligand in periodontal ligament fibroblasts through the induction of interleukin-1beta and tumor necrosis factor-alpha. Bone 35:629-635.
32. Yamaguchi M, Aihara N, Kojima T, Kasai K. 2006. RANKL increase in compressed periodontal ligament cells from root resorption. J Dent Res 85:751-756.