A sensitive and high-throughput LC-MS/MS method for the quantification of pegylated-interferon-α2a in human serum using monolithic C18 solid phase extraction for enrichment

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 18-19, 2009, Pages 1737-1742

  Yang, Ziping ^a   Ke, June ^a   Hayes, Michael ^a   Bryant, Matthew ^a   Tse, Francis L S ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Human serum; LC MS MS; Monolithic SPE; PEG IFN; Pegylated interferon; Quantification; Therapeutic protein

Indexed keywords

HUMAN SERUM; LC-MS/MS; MONOLITHIC SPE; PEG-IFN; PEGYLATED-INTERFERON; QUANTIFICATION; THERAPEUTIC PROTEIN;

ANTIBIOTICS; BODY FLUIDS; EXTRACTION; GLYCOPROTEINS; PATIENT TREATMENT; POLYETHYLENE GLYCOLS; SOLAR RADIATION;

INTERFERONS;

ALPHA2A INTERFERON; HUMAN GROWTH HORMONE; PEGINTERFERON ALPHA2A; RIBAVIRIN;

ACCURACY; ANTIVIRAL THERAPY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG COMPETITION; DRUG METABOLISM; HEPATITIS C; HIGH THROUGHPUT SCREENING; HUMAN; LIQUID CHROMATOGRAPHY; LIVER DISEASE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; STEADY STATE; TREATMENT DURATION;

ANTIVIRAL AGENTS; CHROMATOGRAPHY, LIQUID; HUMANS; INTERFERON ALFA-2A; MASS SPECTROMETRY; POLYETHYLENE GLYCOLS; SENSITIVITY AND SPECIFICITY;

EID: 66149135290     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.04.033     Document Type: Article

References (21)

1. Dhalluin C., Ross A., Leuthold L.A., Foser S., Gsell B., Muller F., and Senn H. Bioconjugate Chem. 16 (2005) 504
2. Rajender R.K., Modi M.W., and Pedder S. Adv. Drug Deliv. Rev. 54 (2002) 571
3. Hadziyannis S.J., and Papatheodoridis G.V. Expert Opin. Pharmacother. 4 (2003) 541
4. Modi M.W., Lamb M.W., and Shiomi M. Adv. Exp. Med. Biol. 519 (2003) 59
5. Foster G.R. Expert Opin. Pharmacother. 4 (2003) 685
6. Fried M.W., and Hadziyannis S.J. Semin. Liver Dis. 24 Suppl 2 (2004) 47
7. Cooksley W.G. Expert Opin. Pharmacother. 6 (2005) 1373
8. Gish R.G., Lau D.T., Schmid P., and Perrillo R. Am. J. Gastroenterol. 102 (2007) 2718
9. Rinner O., Mueller L.N., Hubalek M., Muller M., Gstaiger M., and Aebersold R. Nat. Biotechnol. 25 (2007) 345
10. Mirza S.P., and Olivier M. Physiol. Genomics 33 (2008) 3
11. Mann M. Nat. Biotechnol. 17 (1999) 954
12. Omenn G.S., States D.J., Adamski M., Blackwell T.W., Menon R., Hermjakob H., Apweiler R., Haab B.B., Simpson R.J., Eddes J.S., Kapp E.A., Moritz R.L., Chan D.W., Rai A.J., Admon A., Aebersold R., Eng J., Hancock W.S., Hefta S.A., Meyer H., Paik Y.K., Yoo J.S., Ping P., Pounds J., Adkins J., Qian X., Wang R., Wasinger V., Wu C.Y., Zhao X., Zeng R., Archakov A., Tsugita A., Beer I., Pandey A., Pisano M., Andrews P., Tammen H., Speicher D.W., and Hanash S.M. Proteomics 5 (2005) 3226
13. Ramstrom M., Hagman C., Mitchell J.K., Derrick P.J., Hakansson P., and Bergquist J. J. Proteome. Res. 4 (2005) 410
14. Plavina T., Wakshull E., Hancock W.S., and Hincapie M. J. Proteome. Res. 6 (2007) 662
15. Seam N., Gonzales D.A., Kern S.J., Hortin G.L., Hoehn G.T., and Suffredini A.F. Clin. Chem. 53 (2007) 1915
16. Zolotarjova N., Martosella J., Nicol G., Bailey J., Boyes B.E., and Barrett W.C. Proteomics 5 (2005) 3304
17. Ackermann B.L., and Berna M.J. Expert Rev. Proteomics 4 (2007) 175
18. Berna M.J., Zhen Y., Watson D.E., Hale J.E., and Ackermann B.L. Anal. Chem. 79 (2007) 4199
19. Yang Z., Hayes M., Fang X., Daley M.P., Ettenberg S., and Tse F.L. Anal. Chem. 79 (2007) 9294
20. Anderson N.L., and Anderson N.G. Mol. Cell Proteomics 1 (2002) 845
21. Dhalluin C., Ross A., Huber W., Gerber P., Brugger D., Gsell B., and Senn H. Bioconjug. Chem. 16 (2005) 518