Progression of NRAS and BRAF mutations in cutaneous melanoma

Journal of Investigative Dermatology

Volumn 129, Issue 6, 2009, Pages 1318-

  Rosso, Ritchie ^a   Romagosa, Yvonne ^a   Kirsner, Robert S ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; DNA;

DISEASE COURSE; DNA SEQUENCE; GENE MUTATION; HISTOLOGY; HUMAN; LASER CAPTURE MICRODISSECTION; MELANOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SHORT SURVEY; SKIN CANCER; SKIN CARCINOGENESIS;

EID: 66149122143     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.107     Document Type: Short Survey

References (6)

1. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417:949-54
2. Dong J, Phelps RG, Qiao R, Yao S, Bernard O, Ronai Z et al. (2003) BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma. Cancer Res 63:3883-5
3. Goel VK, Lazar AJF, Warneke CL, Redston MS, Haluska FG (2006) Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. J Invest Dermatol 126:154-60
4. Greene Vr, johnson MM, Grimm Ea, Ellerhorst ja (2009) Frequencies of NRAS and BRAF mutations increase from the radial to the vertical growth phase in cutaneous melanoma. J Invest Dermatol 129:1483-8
5. Omholt K, Platz A, Kante L, Ringborg U, Hansson J (2003) NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Clin Cancer Res 9:6483-8
6. Smalley KS, Herlyn M (2005) Targeting intracellular signaling pathways as a novel strategy in melanoma therapeutics. Ann NY Acad Sci 1059:16-25