Indications of carbapenem resistance evolution through heteroresistance as an intermediate stage in Acinetobacter baumannii after carbapenem administration

Revista do Instituto de Medicina Tropical de Sao Paulo

Volumn 51, Issue 2, 2009, Pages 111-113

  Superti, Silvana Vargas ^a   Martins, Daniela De Souza ^a   Caierão, Juliana ^a   Soares, Fabiana Da Silva ^a   Prochnow, Taísa ^a   Zavascki, Alexandre Prehn ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Acinetobacter baumannii; Carbapenem heteroresistance; Meropenem treatment

Indexed keywords

CARBAPENEM; CARBAPENEMASE; IMIPENEM; MEROPENEM; POLYMYXIN B;

ABDOMINAL ABSCESS; ACINETOBACTER BAUMANNII; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; CASE REPORT; DISK DIFFUSION; EPSILOMETER TEST; FEMALE; HUMAN; NONHUMAN; POLYMERASE CHAIN REACTION; SEPTIC SHOCK;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; AGED; ANTI-BACTERIAL AGENTS; DISK DIFFUSION ANTIMICROBIAL TESTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; HUMANS; IMIPENEM; PHENOTYPE; THIENAMYCINS;

EID: 66149116016     PISSN: 00364665     EISSN: 16789946     Source Type: Journal    
DOI: 10.1590/S0036-46652009000200010     Document Type: Article

References (12)

1. AFZAL-SHAH, M.; WOODFORD, N. & LIVERMORE, D.M. - Characterization of OXA-25, OXA-26, and OXA-27, molecular class D beta-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother., 45: 583-588, 2001.
2. BOU, G.; OLIVER, A. & MARTINEZ-BELTRAN, J. - OXA-24, a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain. Antimicrob. Agents Chemother., 44: 1556-1561, 2000.
3. th Informational Supplement. Wayne, CLSI, 2006.
4. DIJKSHOORN, L.; NEMEC, A. & SEIFERT, H. - An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat. Rev. Microbiol., 5: 939-951, 2007.
5. ELLINGTON, M.J.; KISTLER, J.; LIVERMORE, D.M. & WOODFORD, N. - Multiplex PCR for rapid detection of genes encoding acquired metallo-β-lactamases. J. Antimicrob. Chemother., 59: 321-322, 2007.
6. LI, J.; RAYNER, C.R.; NATION, R.L. et al. - Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii. Antimicrob. Agents Chemother., 50: 2946-2950, 2006.
7. POURNARAS, S.; IKONOMIDIS, A.; MARKOGIANNAKIS, A.; MANIATIS, A.N. & TSAKRIS, A. - Heteroresistance to carbapenems in Acinetobacter baumannii. J. Antimicrob. Chemother., 55: 1055-1056, 2005.
8. POURNARAS, S.; IKONOMIDIS, A.; MARKOGIANNAKIS, A. et al. - Characterization of clinical isolates of Pseudomonas aeruginosa heterogeneously resistant to carbapenems. J. med. Microbiol., 56: 66-70, 2007.
9. POURNARAS, S.; IKONOMIDIS, A.; NEOU, E. et al. - Piperacillin/tazobactam- heteroresistant Pseudomonas aeruginosa from urinary infection, successfully treated by piperacillin/tazobactam. J. Antimicrob. Chemother., 61: 757-758, 2008.
10. RINDER, H. - Hetero-resistance: an under-recognized confounder in diagnosis and therapy? J. med. Microbiol., 50: 1018-1020, 2001.
11. TURTON, J.F.; WOODFORD, N.; GLOVER, J. et al. - Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species. J. clin. Microbiol., 44: 2974-2976, 2006.
12. ZAVASCKI, A.P.; SOARES, F.C.; SUPERTI, S.V. et al. - Stable carbapenem susceptibility rates among multidrug-resistant Acinetobacter spp. strains in a setting of high prevalence of carbapenem-resistant Pseudomonas aeruginosa. Int. J. Antimicrob. Agents, 30: 187-189, 2007.