Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase

Journal of Biological Chemistry

Volumn 284, Issue 14, 2009, Pages 9566-9577

  Inoue, Tsuyoshi ^a   Okino, Nozomu ^b,d   Kakuta, Yoshimitsu ^b   Hijikata, Atsushi ^c   Okano, Hiroyuki ^a   Goda, Hatsumi M ^b   Tani, Motohiro ^b   Sueyoshi, Noriyuki ^b,e   Kambayashi, Kouji ^a   Matsumura, Hiroyoshi ^a   Kai, Yasushi ^a,f   Ito, Makoto ^b,d  

^a OSAKA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c RIKEN Center for Integrative Medical Sciences   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e KAGAWA UNIVERSITY   (Japan)

^f FUKUI UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANOLAMINES; BACTERIA; BINDING SITES; ENZYMES; FATTY ACIDS; HYDROLYSIS;

CONFORMATIONAL CHANGE; COORDINATION SITES; MOLECULAR MECHANISM; MUTATIONAL ANALYSIS; N-TERMINAL DOMAINS; PSEUDOMONAS AERUGINOSA; STRUCTURAL COMPARISON; SUBSTRATE-BINDING SITES;

CERAMIDES;

ACYLSPHINGOSINE DEACYLASE; CALCIUM ION; CARBOXYPEPTIDASE; CERAMIDE; FATTY ACID; MAGNESIUM ION; SPHINGOLIPID; SPHINGOSINE; ZINC ION; METAL; NEUTRAL CERAMIDASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING KINETICS; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; ENZYME DEGRADATION; ENZYME SUBSTRATE; ENZYME SYNTHESIS; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; LIPID HYDROLYSIS; LIPOGENESIS; MOLECULAR MECHANICS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PSEUDOMONAS AERUGINOSA; RAT; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

EUKARYOTA; PSEUDOMONAS AERUGINOSA; RATTUS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE; CERAMIDES; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROLYSIS; METALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NEUTRAL CERAMIDASE; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS AERUGINOSA; RATS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 66149115594     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808232200     Document Type: Article

References (56)

1. Hannun, Y. A., and Obeid, L. M. (2008) Nat. Rev. Mol. Cell Biol. 9, 139-150
2. Pettus, B. J., Chalfant, C. E., and Hannun, Y. A. (2002) Biochim. Biophys. Acta. 1585, 114-125
3. Hannun, Y. A., and Bell, R. M. (1987) Science 235, 670-674
4. Spiegel, S., and Milstien, S. (2003) Nat. Rev. Mol. Cell Biol. 4, 397-407
5. Hait, N. C., Oskeritzian, C. A., Paugh, S. W., Milstien, S., and Spiegel, S. (2006) Biochim. Biophys. Acta. 1758, 2016-2026
6. Gatt, S. (1963) J. Biol. Chem. 238, 3131-3133
7. Kita, K., Okino, N., and Ito, M. (2000) Biochim. Biophys. Acta. 1485, 111-120
8. Okino, N., He, X., Gatt, S., Sandhoff, K., Ito, M., and Schuchman, E. H. (2003) J. Biol. Chem. 278, 29948-29953
9. Merrill, A. H., Jr., and Wang, E. (1986) J. Biol. Chem. 261, 3764-3769
10. Tani, M., Ito, M., and Igarashi, Y. (2007) Cell. Signal. 19, 229-237
11. Ito, M., Okino, N., Tani, M., Mitsutake, S., and Kita, K. (2002) Ceramide Signaling, pp. 41-48, Landes BioScience Press Inc., Georgetown, TX
12. Okino, N., Tani, M., Imayama, S., and Ito, M. (1998) J. Biol. Chem. 273, 14368-14373
13. Okino, N., Ichinose, S., Omori, A., Imayama, S., Nakamura, T., and Ito, M. (1999) J. Biol. Chem. 274, 36616-36622
14. Monjusho, H., Okino, N., Tani, M., Maeda, M., Yoshida, M., and Ito, M. (2003) Biochem. J. 376, 473-479
15. Yoshimura, Y., Okino, N., Tani, M., and Ito, M. (2002) J. Biochem. (Tokyo) 132, 229-236
16. Yoshimura, Y., Tani, M., Okino, N., Iida, H., and Ito, M. (2004) J. Biol. Chem. 279, 44012-44022
17. Tani, M., Okino, N., Mitsutake, S., Tanigawa, T., Izu, H., and Ito, M. (2000) J. Biol. Chem. 275, 3462-3468
18. Tani, M., Okino, N., Mori, K., Tanigawa, T., Izu, H., and Ito, M. (2000) J. Biol. Chem. 275, 11229-11234
19. Mitsutake, S., Tani, M., Okino, N., Mori, K., Ichinose, S., Omori, A., Iida, H., Nakamura, T., and Ito, M. (2001) J. Biol. Chem. 276, 26249-26259
20. El Bawab, S., Roddy, P., Qian, T., Bielawska, A., Lemasters, J. J., and Hannun, Y. A. (2000) J. Biol. Chem. 275, 21508-21513
21. Hwang, Y. H., Tani, M., Nakagawa, T., Okino, N., and Ito, M. (2005) Biochem. Biophys. Res. Commun. 331, 37-42
22. Tani, M., Iida, H., and Ito, M. (2003) J. Biol. Chem. 278, 10523-10530
23. Tani, M., Okino, N., Sueyoshi, N., and Ito, M. (2004) J. Biol. Chem. 279, 29351-29358
24. Okino, N., and Ito, M. (2007) J. Biol. Chem. 282, 6021-6030
25. Acharya, J. K., Dasgupta, U., Rawat, S. S., Yuan, C., Sanxaridis, P. D., Yonamine, I., Karim, P., Nagashima, K., Brodsky, M. H., Tsunoda, S., and Acharya, U. (2008) Neuron 57, 69-79
26. Acharya, U., Mowen, M. B., Nagashima, K., and Acharya, J. K. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 1922-1926
27. Acharya, U., Patel, S., Koundakjian, E., Nagashima, K., Han, X., and Acharya, J. K. (2003) Science 299, 1740-1743
28. Rohrbough, J., Rushton, E., Palanker, L., Woodruff, E., Matthies, H. J., Acharya, U., Acharya, J. K., and Broadie, K. (2004) J. Neurosci. 24, 7789-7803
29. Tani, M., Igarashi, Y., and Ito, M. (2005) J. Biol. Chem. 280, 36592-36600
30. Kono, M., Dreier, J. L., Ellis, J. M., Allende, M. L., Kalkofen, D. N., Sanders, K. M., Bielawski, J., Bielawska, A., Hannun, Y. A., and Proia, R. L. (2006) J. Biol. Chem. 281, 7324-7331
31. Otwinowski, Z., and Minor, W. (1993) in Proceedings of the CCP4 Study Weekend, Data Collection and Processing, pp. 56-62, Science and Engineering Research Council Daresbury Laboratory, Warrington, UK
32. Collaborative Computational Project 4 (1994) Acta. Crystallogr. Sect. D. Biol. Crystallogr. 50, 760-763
33. Terwilliger, T. C., and Berendzen, J. (1999) Acta. Crystallogr. Sect. D Biol. Crystallogr. 55, 849-861
34. Terwilliger, T. C. (2003) Methods Enzymol. 374, 22-37
35. Perrakis, A., Morris, R., and Lamzin, V. S. (1999) Nat. Struct. Biol. 6, 458-463
36. Emsley, P., and Cowtan, K. (2004) Acta. Crystallogr. Sect. D Biol. Crystallogr. 60, 2126-2132
37. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta. Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
38. Vagin, A., and Teplyakov, A. (2000) Acta. Crystallogr. Sect. D Biol. Crystallogr. 56, 1622-1624
39. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta. Crystallogr. Sect. D Biol. Crystallogr. 53, 240-255
40. Kabsch, W., and Sander, C. (1983) FEBS. Lett. 155, 179-182
41. Sarkar, G., and Sommer, S. S. (1990) BioTechniques 8, 404-407
42. Marti-Renom, M. A., Stuart, A. C., Fiser, A., Sanchez, R., Melo, F., and Sali, A. (2000) Annu. Rev. Biophys. Biomol. Struct. 29, 291-325
43. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680
44. Shen, M. Y., and Sali, A. (2006) Protein Sci. 15, 2507-2524
45. Holm, L., and Sander, C. (1993) J. Mol. Biol. 233, 123-138
46. Holm, L., and Sander, C. (1996) Science 273, 595-603
47. Ancellin, N., Colmont, C., Su, J., Li, Q., Mittereder, N., Chae, S. S., Stefansson, S., Liau, G., and Hla, T. (2002) J. Biol. Chem. 277, 6667-6675
48. Olsson, M., Duan, R. D., Ohlsson, L., and Nilsson, A. (2004) Am. J. Physiol. 287, G929-G937
49. Nilsson, A. (1969) Biochim. Biophys. Acta 176, 339-347
50. Ohlsson, L., Palmberg, C., Duan, R. D., Olsson, M., Bergman, T., and Nilsson, A. (2007) Biochimie (Paris) 89, 950-960
51. Hamburger, Z. A., Brown, M. S., Isberg, R. R., and Bjorkman, P. J. (1999) Science 286, 291-295
52. Nagar, B., Overduin, M., Ikura, M., and Rini, J. M. (1996) Nature 380, 360-364
53. Wu, B. X., Snook, C. F., Tani, M., Bullesbach, E. E., and Hannun, Y. A. (2007) J. Lipid Res. 48, 600-608
54. Galadari, S., Wu, B. X., Mao, C., Roddy, P., El Bawab, S., and Hannun, Y. A. (2006) Biochem. J. 393, 687-695
55. Shtraizent, N., Eliyahu, E., Park, J. H., He, X., Shalgi, R., and Schuchman, E. H. (2008) J. Biol. Chem. 283, 11253-11259
56. Nicholls, A., Sharp, K. A., and Honig, B. (1991) Proteins 11, 281-296