Cellular and molecular characterization of a feline insulinoma

Journal of Veterinary Internal Medicine

Volumn 23, Issue 2, 2009, Pages 383-387

  Jackson, T C ^a   Debey, B ^a   Lindbloom Hawley, S ^a   Jones, B T ^b   Schermerhorn, T ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b Animal Clinic   (United States)

Author keywords

Endocrine cancer; Gene expression; Hypoglycemia; Immunohistochemistry; Islet cell tumor; Pancreas

Indexed keywords

FELIDAE;

DNA; GLUCOKINASE; GLUCOSE TRANSPORTER 2; HEXOKINASE; INSULIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; CAT; CAT DISEASE; GENE EXPRESSION; GENETICS; IMMUNOHISTOCHEMISTRY; INSULINOMA; METABOLISM; PANCREAS ISLET BETA CELL; PANCREAS TUMOR; POLYMERASE CHAIN REACTION;

ANIMALS; CAT DISEASES; CATS; DNA, NEOPLASM; GENE EXPRESSION; GLUCOKINASE; GLUCOSE TRANSPORTER TYPE 2; HEXOKINASE; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; INSULINOMA; PANCREATIC NEOPLASMS; POLYMERASE CHAIN REACTION;

EID: 66149115279     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2008.0267.x     Document Type: Article

References (18)

1. McMillan FD, Barr B, Feldman EC. Functional pancreatic islet cell tumor in a cat. J Am Anim Hosp 1985;21:741-746.
2. O'Brien TD, Norton F, Turner TM, Johnson KH. Pancreatic endocrine tumor in a cat: Clinical, pathological, and immunohistochemical evaluation. J Am Anim Hosp 1990;26:453-457.
3. Hawks D, Peterson ME, Hawkins KL, Rosebury WS. Insulin secreting pancreatic (islet cell) carcinoma in a cat. J Vet Intern Med 1992;6:193-196.
4. Kraje AC. Hypoglycemia and irreversible neurologic complications in a cat with insulinoma. J Am Vet Med Assoc 2003;223: 812-814, 810.
5. Greene SN, Bright RM. Insulinoma in a cat. J Small Anim Pract 2008;49:38-40.
6. Quintens R, Hendrickx N, Lemaire K, Schuit F. Why expression of some genes is disallowed in beta-cells. Biochem Soc Trans 2008;36(Part 3):300-305.
7. Matschinsky FM. Regulation of pancreatic beta-cell glucokinase: From basics to therapeutics. Diabetes 2002;51(Suppl 3):S394-S404.
8. Wang H, Iynedjian PB. Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase. Proc Natl Acad Sci USA 1997;94:4372-4377.
9. Smith TA. Mammalian hexokinases and their abnormal expression in cancer. Br J Biomed Sci 2000;57:170-178.
10. Myers NC III, Andrews GA, Chard-Bergstrom C. Chromogranin A plasma concentration and expression in pancreatic islet cell tumors of dogs and cats. Am J Vet Res 1997;58:615-620.
11. Niswender KD, Shiota M, Postic C, et al. Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J Biol Chem 1997;272:22570-22575.
12. Terauchi Y, Sakura H, Yasuda K, et al. Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J Biol Chem 1995;270: 30253-30256.
13. Lankat-Buttgereit B, Fehmann HC, Hering BJ, et al. Expression of the ras-related rab3a gene in human insulinomas and normal human pancreatic islets. Pancreas 1994;9:434-438.
14. Baroni MG, Cavallo MG, Mark M, et al. Beta-cell gene expression and functional characterisation of the human insulinoma cell line CM. J Endocrinol 1999;161:59-68.
15. Donley VR, Hiskett EK, Kidder AC, Schermerhorn T. ATP-sensitive potassium channel (KATP channel) expression in the normal canine pancreas and in canine insulinomas. BMC Vet Res 2005;1:8. Published online 2005 November 2. doi: 10.1186/1746-6148-1-8.
16. Wang H, Iynedjian PB. Acute glucose intolerance in insulinoma cells with unbalanced overexpression of glucokinase. J Biol Chem 1997;272:25731-25736.
17. Hussain K. Insights in congenital hyperinsulinism. Endocr Dev 2007;11:106-121.
18. Giddings SJ, Carnaghi LR, Shalwitz RA. Hypoglycemia but not hyperglycemia induces rapid changes in pancreatic beta cell gene transcription. Am J Physiol Endocrinol Metab 1993;265(28):E259-E266.