Cytochrome P-450 polymorphisms and response to clopidogrel

New England Journal of Medicine

Volumn 360, Issue 21, 2009, Pages 2249-2251

  Taubert, Dirk ^a   Bouman, Heleen J ^b   Van Werkum, Jochem W ^b  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^b ST ANTONIUS HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXO CLOPIDOGREL; 5 HYDROXYOMEPRAZOLE; CLOPIDOGREL; CYTOCHROME P450; CYTOCHROME P450 2C19; DRUG METABOLITE; OMEPRAZOLE; UNCLASSIFIED DRUG; 2-OXO-CLOPIDOGREL; ANTITHROMBOCYTIC AGENT; CYP2C19 PROTEIN, HUMAN; DRUG DERIVATIVE; TICLOPIDINE; UNSPECIFIC MONOOXYGENASE;

DRUG RESPONSE; DRUG TRANSFORMATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; LETTER; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; BIOTRANSFORMATION; GENE LINKAGE DISEQUILIBRIUM; GENETICS; METABOLISM; MICROSOME; NOTE;

ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; HUMANS; LINKAGE DISEQUILIBRIUM; MICROSOMES; OMEPRAZOLE; PLATELET AGGREGATION INHIBITORS; POLYMORPHISM, GENETIC; TICLOPIDINE;

EID: 66149111376     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc090391     Document Type: Letter

References (3)

1. Mega JL, Close SL, Wiviott SD, et al. Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med 2009;360:354-362
2. Pereillo JM, Maftouh M, Andrieu A, et al. Structure and stereochemistry of the active metabolite of clopidogrel. Drug Metab Dispos 2002;30:1288-1295 (Pubitemid 35265838)
3. Kanazawa H, Okada A, Higaki M, Yokota H, Mashige F, Nakahara K. Stereospecific analysis of omeprazole in human plasma as a probe for CYP2C19 phenotype. J Pharm Biomed Anal 2003;30:1817-1824 (Pubitemid 35453985)