18F-FDG PET for semiquantitative evaluation of acute allograft rejection and immunosuppressive therapy efficacy in rat models of liver transplantation

Journal of Nuclear Medicine

Volumn 50, Issue 5, 2009, Pages 827-830

  Tsuji, Atsushi B ^a   Morita, Miwa ^b   Li, Xiao Kang ^c   Sogawa, Chizuru ^a   Sudo, Hitomi ^a   Sugyo, Aya ^a   Fujino, Masayuki ^c,d   Sugioka, Atsushi ^b   Koizumi, Mitsuru ^a   Saga, Tsuneo ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

18F FDG PET; Acute rejection; Immunosuppression; Liver transplantation

Indexed keywords

FLUORODEOXYGLUCOSE F 18; TACROLIMUS; DIAGNOSTIC AGENT; IMMUNOSUPPRESSIVE AGENT; RADIOPHARMACEUTICAL AGENT;

ALLOGRAFT; ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG UPTAKE; IMMUNOSUPPRESSIVE TREATMENT; ISOGRAFT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; ANIMAL; COMPUTER ASSISTED DIAGNOSIS; DISEASE MODEL; EVALUATION; GRAFT REJECTION; HUMAN; LEWIS RAT; METHODOLOGY; PROGNOSIS; SCINTISCANNING; TREATMENT OUTCOME;

ANIMALS; DISEASE MODELS, ANIMAL; FLUORODEOXYGLUCOSE F18; GRAFT REJECTION; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMMUNOSUPPRESSIVE AGENTS; LIVER TRANSPLANTATION; MALE; POSITRON-EMISSION TOMOGRAPHY; PROGNOSIS; RADIOPHARMACEUTICALS; RATS; RATS, INBRED LEW; TREATMENT OUTCOME;

EID: 66149092752     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.058925     Document Type: Article

References (10)

1. Belle SH, Porayko MK, Hoofnagle JH, Lake JR, Zetterman RK. Changes in quality of life after liver transplantation among adults: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Liver Transplantation Database (LTD). Liver Transpl Surg. 1997;3:93-104. (Pubitemid 27114020)
2. Roberts MS, Angus DC, Bryce CL, Valenta Z, Weissfeld L. Survival after liver transplantation in the United States: a disease-specific analysis of the UNOS database. Liver Transpl. 2004;10:886-897.
3. Jones KD, Ferrell LD. Interpretation of biopsy findings in the transplant liver. Semin Diagn Pathol. 1998;15:306-317.
4. Portmann B, Slapak GI, Gane E, Williams R. Pathology and biopsy diagnosis of the transplanted liver. Verh Dtsch Ges Pathol. 1995;79:277-290.
5. Hori T, Iida T, Yagi S, et al. K(ICG) value, a reliable real-time estimator of graft function, accurately predicts outcomes in adult living-donor liver transplantation. Liver Transpl. 2006;12:605-613.
6. Reding R, Gras J, Truong DQ, Wieers G, Latinne D. The immunological monitoring of alloreactive responses in liver transplant recipients: a review. Liver Transpl. 2006;12:373-383.
7. Kamada N, Davies HS, Roser B. Reversal of transplantation immunity by liver grafting. Nature. 1981;292:840-842.
8. Hara Y, Funeshima-Fuji N, Fujino M, et al. A novel chemical compound, NK026680, targets dendritic cells to prolong recipient survival after rat liver grafting. Transplantation. 2007;84:407-414.
9. 18F]fluoro-2-deoxyglucose as a potential agent in the prediction of graft rejection by positron emission tomography. Transplantation. 1998;66:1101-1103.
10. 18F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation. J Nucl Med. 2002;43:658-663.