Alkaloid synthesis and accumulation in Leucojum aestivum in vitro cultures

Natural Product Communications

Volumn 4, Issue 3, 2009, Pages 359-364

  Berkov, Strahil ^a   Pavlov, Atanas ^b   Georgiev, Vasil ^b   Bastida, Jaume ^a   Burrus, Monique ^c   Ilieva, Mladenka ^b   Codina, Carles ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^c UNIVERSITÉ PAUL SABATIER   (France)

Author keywords

Amaryllidaceae alkaloids; Galanthamine; In vitro cultures; Leucojum aestivum

Indexed keywords

ALKALOID; EPIGALANTHAMINE; EPINORGALANTHAMINE; GALANTAMINE; HAEMANTHAMINE; HORDENINE; LYCORINE; METHYLTYRAMINE; N FORMYLNORGALANTHAMINE; NARWEDINE; SANGUININE; TRISPHAERIDINE; UNCLASSIFIED DRUG; AMARYLLIDACEAE ALKALOID; PHENANTHRIDINE DERIVATIVE;

ARTICLE; CALLUS CULTURE; DRUG ISOLATION; DRUG SYNTHESIS; FLOWER; IN VITRO STUDY; LEUCOJUM AESTIVUM; MASS FRAGMENTOGRAPHY; MEDICINAL PLANT; NONHUMAN; PHYTOCHEMISTRY; PLANT BULB; PLANT LEAF; PLANT ROOT; PLANT STEM; PLANT TISSUE; SHOOT; TISSUE CULTURE; ANGIOSPERM; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CULTURE TECHNIQUE; METABOLISM;

AMARYLLIDACEAE; LEUCOJUM AESTIVUM;

ALKALOIDS; AMARYLLIDACEAE ALKALOIDS; CULTURE TECHNIQUES; GALANTAMINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LILIACEAE; MOLECULAR STRUCTURE; PHENANTHRIDINES;

EID: 66149087648     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0900400328     Document Type: Article

References (17)

1. Thomsen T, Zendeh H, Fisher J, Kewitz H. (1991) In vitro effects of various cholinesterase inhibitors on acetyl and butyrylcholinesterase of healthy volunteers. Biochemistry and Pharmacology, 41, 139-141.
2. Heinrich M, Teoh H. (2004) Galanthamine from snowdrop - the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. Journal of Ethnopharmacology, 92, 147-162. (Pubitemid 38610095)
3. Codina C. (2002) Production of galanthamine by Narcissus tissues in vitro. In Medicinal and Aromatic Plants - Industrial Profiles: Narcissus and Daffodil (The Genus Narcissus). Hanks G (Ed). Taylor and Francis, London and New York, 215-241.
4. Colque R, Viladomat F, Bastida J, Codina C. (2004) Improved production of galanthamine and related alkaloids by methyl jasmonate in Narcissus confusus shoot-clumps. Planta Medica, 70, 1180-1188. (Pubitemid 40101101)
5. Diop M, Ptak A, Chrétien F, Henry M, Chapleur Y, Laurain-Mattar D. (2006) Galanthamine content of bulbs and in vitro cultures of Leucojum aestivum. Natural Product Communications, 1, 475-479.
6. Pavlov A, Berkov S, Courot E, Gocheva T, Tuneva D, Pandova B, Georgiev V, Yanev S, Burrus M, Ilieva M. (2007) Galanthamine production by Leucojum aestivum in vitro systems. Process Biochemistry, 42, 734-739. (Pubitemid 46420786)
7. Georgieva L, Berkov S, Kondakova V, Bastida J, Viladomat F, Atanassov A, Codina C. (2007) Alkaloid variability in Leucojum aestivum from wild populations. Zeitschrift fur Naturforschung, 62c, 627-635.
8. Sellés M, Viladomat F, Bastida J, Codina C. (1999) Callus induction, somatic embryogenesis and organogenesis in Narcissus confusus: correlation between the state of differentiation and the content of galanthamine and related alkaloids. Plant Cell Reports, 18, 646-651.
9. Hemm MR, Rider SD, Ogas J, Murry D, Chapple C. (2004) Light induces phenylpropanoid metabolism in Arabidopsis roots. The Plant Journal, 38, 765-778.
10. Abbasi B, Tian C-L, Murch S, Saxena P, Liu C-Z. (2007) Light-enhanced caffeic acid derivatives biosynthesis in hairy root cultures of Echinacea purpurea. Plant Cell Reports, 26, 1367-1372.
11. Berkov S, Bastida J, Viladomat F, Codina C. (2008) Analysis of galanthamine type alkaloids by capillary gas chromatographymass spectrometry in plants. Phytochemical Analysis, 19, 285-293.
12. Kreh M, Matusch R, Witte L. (1995) Capillary gas chromatography-mass spectrometry of Amaryllidaceae alkaloids. Phytochemistry, 38, 773-776.
13. Nakano M, Nomizu T, Mizunashi K, Suzuki M, Mori S, Kuwayama S, Hayashi M, Umehara H, Oka E, Kobayashi K. (2006) Somaclonal variation in Tricyrtis hirta plants regenerated from 1-year-old embryogenic callus cultures. Scientia Horticulturae, 110, 366-371.
14. Suau R, Gómez A, Rico R, Vázquez-Tato M, Castedo L, Riguera R. (1988) Alkaloid N-oxides of Amaryllidaceae. Phytochemistry, 27, 3285-3287.
15. Ali A, El-Sayed H, Abdallah O, Steglich W. (1986) Oxocrinine and other alkaloids from Crinum americanum. Phytochemistry, 25, 2399-2401.
16. Youssef D, Frahm A. (1998) Alkaloids of the flowers of Pancratium maritimum, Planta Medica, 64, 669-670.
17. Bastida J, Lavilla R, Viladomat F. (2006) Chemical and biological aspects of Narcissus alkaloids. In The Alkaloids, Vol. 63, Cordell G. (Ed), Elsevier Scientific Publishing, Amsterdam, 87-179.