Dietary soy isoflavone replacement improves detrusor overactivity of ovariectomized rats with altered connexin-43 expression in the urinary bladder

BJU International

Volumn 103, Issue 10, 2009, Pages 1429-1435

  Okada, Shinsuke ^a   Kojima, Yoshiyuki ^a   Hamamoto, Shuzo ^a   Mizuno, Kentaro ^a   Sasaki, Shoichi ^a   Kohri, Kenjiro ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

Connexin 43; Detrusor overactivity; Isoflavones; Oestrogen; Ovariectomy

Indexed keywords

CONNEXIN 43; FUJIFLAVONE P 40; ISOFLAVONE; UNCLASSIFIED DRUG; ISOFLAVONE DERIVATIVE; SOYBEAN PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; BLADDER FILLING; CONTROLLED STUDY; CYSTOMETRY; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG MECHANISM; FEMALE; FOOD INTAKE; NONHUMAN; OVARIECTOMY; OVERACTIVE BLADDER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SOYBEAN; SPRAGUE DAWLEY RAT; TREATMENT RESPONSE; ANIMAL; DIET THERAPY; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CONNEXIN 43; FEMALE; ISOFLAVONES; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SOYBEAN PROTEINS; URINARY BLADDER, OVERACTIVE;

EID: 66149086533     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2008.08325.x     Document Type: Article

References (33)

1. Abrams P, Cardozo L, Fall M et al. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-Committee of the International Continence Society. Neurourol Urodyn 2002 21 : 167 78
2. Ishigooka M, Hashimoto T, Tomaru M. Effect of hormonal replacement therapy in post menopausal women with chronic irritative voiding symptoms. Int Urogynecol J Pelvic Floor Dysfunct 1994 5 : 208 11
3. Long CY, Liu CM, Hsu SC, Chen YH, Wu CH, Tsai EM. A randomized comparative study of the effects of oral and topical estrogen therapy on the lower urinary tract of hysterectomized postmenopausal women. Fertil Steril 2006 85 : 155 60
4. Cardozo L, Lose G, McClish D, Versi E. A systematic review of the effects of estrogens for symptoms suggestive of overactive bladder. Acta Obstet Gynecol Scand 2004 83 : 892 7
5. 2) in ovariectomized (ovx) rats. Endocrine 2004 23 : 25 32
6. Farquhar CM, Marjoribanks J, Lethaby A et al. Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev 2005 3 : CD004143
7. Foth D, Cline JM. Effects of mammalian and plant estrogens on mammary glands and uteri of macaques. Am J Clin Nutr 1998 68 : 1413S 1417S
8. Tansey G, Hughes CL Jr., Cline JM, Krummer A, Walmer DK, Schmoltzer S. Effects of dietary soybean estrogens on the reproductive tract in female rats. Proc Soc Exp Biol Med 1998 217 : 340 4
9. Ju YH, Allred CD, Allred KF, Karko KL, Doerge DR, Helferich WG. Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen dependent humans breast cancer (MCF-7) tumors implanted in athymic nude mice. J Nutr 2001 131 : 2957 62
10. Wang TT, Sathyamoorthy N, Phang JM. Molecular effects of genistein on estrogen receptor mediated pathways. Carcinogenesis 1996 17 : 271 5
11. Kurzer MS. Phytoestrogen supplement use by women. J Nutr 2003 133 : 1983S 1986S
12. Brading AF, McCloskey KD. Mechanisms of Disease: specialized interstitial cells of the urinary tract - an assessment of current knowledge. Nat Clin Pract Urol 2005 2 : 546 54
13. Ikeda Y, Fry C, Hayashi F, Stolz D, Griffiths D, Kanai A. Role of gap junctions in spontaneous activity of the rat bladder. Am J Physiol Renal Physiol 2007 293 : F1018 25
14. Neuhaus J, Pfeiffer F, Wolburg H, Horn LC, Dorschner W. Alterations in connexin expression in the bladder of patients with urge symptoms. BJU Int 2005 96 : 670 6
15. Sui GP, Rothery S, Dupont E, Fry CH, Severs NJ. Gap junctions and connexin expression in human suburothelial interstitial cells. BJU Int 2002 90 : 118 29
16. Christ GJ, Day NS, Day M et al. Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo. Am J Physiol Regul Integr Comp Physiol 2003 284 : R1241 8
17. Li L, Jiang C, Hao P, Li W, Song C, Song B. Changes of gap junctional cell-cell communication in overactive detrusor in rats. Am J Physiol Cell Physiol 2007 293 : C1627 35
18. Haferkamp A, Mundhenk J, Bastian PJ et al. Increased expression of connexin 43 in the overactive neurogenic detrusor. Eur Urol 2004 46 : 799 805
19. Uesugi T, Fukui Y, Yamori Y. Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal japanese women: a four-week study. J Am Coll Nutr 2002 21 : 97 102
20. Streng T, Hedlund P, Talo A, Andersson KE, Gillespie JI. Phasic non-micturition contractions in the bladder of the anaesthetized and awake rat. BJU Int 2006 97 : 1094 101
21. Longhurst PA, Kauer J, Leggett RE, Levin RM. The influence of ovariectomy and estradiol replacement on urinary bladder function in rats. J Urol 1992 148 : 915 9
22. Palea S, Angel J. The effect of ovariectomy on the contractile response of the rat isolated detrusor muscle and urethra. Life Sci 1997 61 : PL21 6
23. Blakeman PJ, Hilton P, Bulmer JN. Oestrogen and progesterone receptor expression in the female lower urinary tract, with reference to oestrogen status. BJU Int 2000 86 : 32 8
24. Mäkelä S, Strauss L, Kuiper G et al. Differential expression of estrogen receptors alpha and beta in adult rat accessory sex glands and lower urinary tract. Mol Cell Endocrinol 2000 170 : 219 29
25. Papka RE, Storey-Workley M, Shughrue PJ et al. Estrogen receptor-alpha and beta- immunoreactivity and mRNA in neurons of sensory and autonomic ganglia and spinal cord. Cell Tissue Res 2001 304 : 193 214
26. Fleischmann N, Christ G, Sclafani T, Melman A. The effect of ovariectomy and long-term estrogen replacement on bladder structure and function in the rat. J Urol 2002 168 : 1265 8
27. Marini H, Minutoli L, Polito F et al. Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. Ann Intern Med 2007 146 : 839 47
28. Fujioka M, Sudo Y, Okumura M et al. Differential effects of isoflavones on bone formation in growing male and female mice. Metabolism 2007 56 : 1142 8
29. Drake MJ, Hedlund P, Harvey IJ, Pandita RK, Andersson KE, Gillespie JI. Partial outlet obstruction enhances modular autonomous activity in the isolated rat bladder. J Urol 2003 170 : 276 9
30. Gillespie JI. The autonomous bladder: a view of the origin of bladder overactivity and sensory urge. BJU Int 2004 93 : 478 83
31. Gillespie JI. A developing view of the origins of urgency: the importance of animal models. BJU Int 2005 96 (Suppl. 1 22 8
32. Hashitani H, Fukuta H, Takano H, Klemm MF, Suzuki H. Origin and propagation of spontaneous excitation in smooth muscle of the guinea-pig urinary bladder. J Physiol 2001 530 : 273 86
33. Sullivan MP, Peters CA, Yalla SV. Effect of gap junction inhibition on rat bladder contractility. J Urol 2003 169 (Suppl. 43