Colorectal cancer in South Africa: A heritable cause suspected in many young black patients

South African Medical Journal

Volumn 99, Issue 2, 2009, Pages 103-106

  Cronjé, Leandra ^a   Paterson, A C ^a   Becker, P J ^b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; PROTEIN P53; MICROSATELLITE DNA; MSH2 PROTEIN, HUMAN; PROTEIN MSH2;

ADOLESCENT; ADULT; AFRICAN AMERICAN; AGED; ARTICLE; CANCER INCIDENCE; COLORECTAL CANCER; CONTROLLED STUDY; EUROPEAN AMERICAN; FEMALE; GENE MUTATION; HEREDITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NEGRO; PROMOTER REGION; PROTEIN EXPRESSION; RACE DIFFERENCE; RETROSPECTIVE STUDY; SOUTH AFRICA; TUMOR BIOPSY; AGE DISTRIBUTION; CAUCASIAN; COLLOID CARCINOMA; COLORECTAL TUMOR; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; RISK; SEX RATIO;

ADENOCARCINOMA, MUCINOUS; ADOLESCENT; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; ODDS RATIO; RETROSPECTIVE STUDIES; SEX DISTRIBUTION; YOUNG ADULT;

EID: 66149085772     PISSN: 02569574     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Hamilton SR, Vogelstein B, Kudo S, Riboli E, Nakamura S, Hainout P. Tumours of the colon and rectum. In: Hamilton SR, Aaltonen LA, eds. Pathology and Genetics of Tumours of the Digestive System. Lyon: IARC Press, 2000: 103-129.
2. Mqoqi N, Kellet P, Sitas F, Jula M. Cancer in South Africa, 1998-1999. Johannesburg: National Cancer Registry of South Africa, National Health Laboratory Service, 2004.
3. Angelo N, Dreyer L. Colorectal carcinoma - a new threat to black patients? A retrospective analysis of colorectal carcinoma received by the Institute for Pathology, University of Pretoria. S Afr Med J 2001; 91: 689-693.
4. Oettlé AG. Primary neoplasms of the alimentary canal in whites and Bantu of the Transvaal, 1949-1953. A histological series. Nat Cancer Inst Monogr 1967; 25: 97-109.
5. Liang JT, Huang KC, Cheng AL, Jeng YM, Wu MS, Wang SM. Clinicopathological and molecular biological features of colorectal cancer in patients less than 40 years of age. Br J Surg 2003; 90: 205-214.
6. Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N Engl J Med 2003; 348: 919-932.
7. Freeman HJ. Heterogeneity of colorectal adenomas, the serrated adenoma, and implications for screening and surveillance. World J Gastroenterol 2008; 14: 3461-3463.
8. Park S-J, Rashid A, Lee J-H, Kim SG, Hamilton SR, Wu T-T. Frequent CpG island methylation in serrated adenomas of the colorectum. Am J Pathol 2003; 162(3): 815-822.
9. Jass JR. Serrated adenoma of the colorectum and the DNA-methylator phenotype. Nat Clin Pract Oncol 2005; 2: 398-405.
10. O'Connell JB, Maggard MA, Liu JH, Etzioni DA, Livingston EH, Ko CY. The rates of colon and rectal cancers are significantly increasing in young adults. Am Surg 2003; 69: 866-872.
11. Ashktorab H, Smoot DT, Farzanmehr H, et al. Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans. Int J Can 2005; 116: 914-919.
12. Jass JR, Do K-A, Simms LA, et al. Morphology of sporadic colorectal cancer with DNA replication errors. Gut 1998; 42: 673-679.
13. Rowley PT. Inherited susceptibility to colorectal cancer. Annu Rev Med 2005; 56: 539-554.
14. Rodriquez-Bigas M, Boland CR, Hamilton SR, et al. A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting highlights and Bethesda guidelines. J Natl Cancer Inst 1997; 89: 1758-1762.
15. Velayos FS, Allen BA, Conrad PG, et al. Low rate of microsatellite instability in young patients with adenomas: Reassessing the Bethesda guidelines. Am J Gastroenterol 2005; 100: 1143-1149.
16. Umar A, Boland CR, Terdiman JP, et al. Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 2004; 96: 261-268.
17. Young J, Simms LA, Biden KG, et al. Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings. Parallel pathways of tumorigenesis. Am J Pathol 2001; 159: 2107-2116.
18. Derks S, Postma C, Carvalho B, et al. Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumor suppressor and DNA repair genes and specific chromosomal alterations. Carcinogenesis 2008; 29: 434-439.
19. Miyakura Y, Sugano K, Konishi F, et al. Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability. Gastroenterology 2001; 121: 1300-1309.
20. Ashktorab H, Smoot DT, Farzanmehr H, et al. Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African-Americans. Int J Cancer 2005; 116: 914-919.
21. Whitehall VL, Walsh MD, Young J, Legget BA, Jass JR. Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level microsatellite instability. Cancer Res 2001; 61: 827-830.
22. Jass JR, Whitehall VL, Young J, Leggett BA. Emerging concepts in colorectal neoplasia. Gastroenterology 2002; 123: 862-876.
23. Mäkinen MJ, George SMC, Jernvall P, Mäkelä J, Vihko P, Karttunen TJ. Colorectal carcinoma associated with serrated adenoma - prevalence, histological features, and prognosis. J Pathol 2001; 193: 286-294.
24. Paluszkiewicz P, Berbec H, Pawlowska-Wakowicz B, Cybulski M, Paszkowska A. p53 protein accumulation in colorectal cancer tissue has prognostic value only in left-sided colon tumours. Cancer Detect Prev 2004; 28: 252-259.
25. Degiannis E, Sliwa K, Levy R, Hale MJ, Saadia R. Clinicopathological trends in colorectal carcinoma in a Black South African population. Trop Gastroenterol 1995; 16: 55-61.