Regulation of pulmonary inflammation and fibrosis through expression of integrins αVβ3 and αVβ5 on pulmonary T lymphocytes

Arthritis and Rheumatism

Volumn 60, Issue 5, 2009, Pages 1530-1539

  Luzina, Irina G ^a   Todd, Nevins W ^a   Nacu, Natalia ^a   Lockatell, Virginia ^a   Choi, Jung ^a   Hummers, Laura K ^b   Atamas, Sergei P ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; BETA5 INTEGRIN; CCL18 CHEMOKINE; CD51 ANTIGEN; CHEMOKINE; COLLAGEN; INTEGRIN ALPHA 5 ANTIBODY; NEUTRALIZING ANTIBODY; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; FIBROSING ALVEOLITIS; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKEMIA CELL LINE; LUNG FIBROBLAST; LUNG FIBROSIS; LUNG LAVAGE; LUNG PARENCHYMA; LYMPHOCYTE FUNCTION; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTEMIC SCLEROSIS; T LYMPHOCYTE;

ANIMALS; ANTIBODIES; BRONCHOALVEOLAR LAVAGE FLUID; CELLS, CULTURED; COLLAGEN; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHAV; INTEGRIN ALPHAVBETA3; JURKAT CELLS; LUNG; MICE; MICE, INBRED C57BL; PULMONARY FIBROSIS; RECEPTORS, VITRONECTIN; SCLERODERMA, SYSTEMIC; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 66049111238     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24435     Document Type: Article

References (26)

1. Schwarz MI, King TE Jr. Interstitial lung diseases. 4th ed. Hamilton (Canada): BC Decker; 2003.
2. Luzina IG, Todd NW, Iacono AT, Atamas SP. Roles of T lymphocytes in pulmonary fibrosis. J Leukoc Biol 2008;83:237-244
3. Luzina IG, Papadimitriou JC, Anderson R, Pochetuhen K, Atamas SP. Induction of prolonged infiltration of T lymphocytes and transient T lymphocyte-dependent collagen deposition in mouse lungs following adenoviral gene transfer of CCL18. Arthritis Rheum 2006;54:2643-2655 (Pubitemid 44205027)
4. Pochetuhen K, Luzina IG, Lockatell V, Choi J, Todd NW, Atamas SP. Complex regulation of pulmonary inflammation and fibrosis by CCL18. Am J Pathol 2007;171:428-437 (Pubitemid 47344676)
5. Atamas SP, Luzina IG, Dai H, Wilt SG, White B. Synergy between CD40 ligation and IL-4 on fibroblast proliferation involves IL-4 receptor signaling. J Immunol 2002;168:1139-1145 (Pubitemid 34094478)
6. Atamas SP, Yurovsky VV, Wise R, Wigley FM, Goter Robinson CJ, Henry P, et al. Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis. Arthritis Rheum 1999;42:1168-1178
7. Luzina IG, Atamas SP, Wise R, Wigley FM, Choi J, Xiao HQ, et al. Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients. Arthritis Rheum 2003;48:2262-2274
8. Luzina IG, Atamas SP, Wise R, Wigley FM, Xiao HQ, White B. Gene expression in bronchoalveolar lavage cells from scleroderma patients. Am J Respir Cell Mol Biol 2002;26:549-557 (Pubitemid 34315862)
9. Atamas SP, Luzina IG, Choi J, Tsymbalyuk N, Carbonetti NH, Singh IS, et al. Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts. Am J Respir Cell Mol Biol 2003;29:743-749
10. Luzina IG, Tsymbalyuk N, Choi J, Hasday JD, Atamas SP. CCL18-stimulated upregulation of collagen production in lung fibroblasts requires Sp1 signaling and basal Smad3 activity. J Cell Physiol 2006;206:221-228 (Pubitemid 41740735)
11. Luzina IG, Highsmith K, Pochetuhen K, Nacu N, Rao JN, Atamas SP. PKCα mediates CCL18-stimulated collagen production in pulmonary fibroblasts. Am J Respir Cell Mol Biol 2006;35:298-305. (Pubitemid 44353397)
12. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, et al. The integrin αvβ6 binds and activates latent TGF β1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999;96:319-328
13. Sheppard D. Integrin-mediated activation of latent transforming growth factor β. Cancer Metastasis Rev 2005;24:395-402. (Pubitemid 41569979)
14. Munger JS, Harpel JG, Giancotti FG, Rifkin DB. Interactions between growth factors and integrins: latent forms of transforming growth factor-β are ligands for the integrin αvβ1. Mol Biol Cell 1998;9:2627-2638 (Pubitemid 28425898)
15. Ludbrook SB, Barry ST, Delves CJ, Horgan CM. The integrin αvβ3 is a receptor for the latency-associated peptides of transforming growth factors β1 and β3. Biochem J 2003;369(Pt 2):311-318
16. Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, et al. The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGFβ1. J Cell Biol 2002;157:493-507.
17. Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K. Increased expression of integrin αvβ3 contributes to the establishment of autocrine TGF-β signaling in scleroderma fibroblasts. J Immunol 2005;175:7708-7718 (Pubitemid 41713471)
18. Asano Y, Ihn H, Jinnin M, Mimura Y, Tamaki K. Involvement of αvβ5 integrin in the establishment of autocrine TGF-β signaling in dermal fibroblasts derived from localized scleroderma. J Invest Dermatol 2006;126:1761-1769 (Pubitemid 44086510)
19. Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K. Involvement of αvβ5 integrin-mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts. Arthritis Rheum 2005;52:2897-2905
20. Helene M, Lake-Bullock V, Zhu J, Hao H, Cohen DA, Kaplan AM. T cell independence of bleomycin-induced pulmonary fibrosis. J Leukoc Biol 1999;65:187-195 (Pubitemid 29077011)
21. Janick-Buckner D, Ranges GE, Hacker MP. Effect of cytotoxic monoclonal antibody depletion of T-lymphocyte subpopulations on bleomycin-induced lung damage in C57BL/6J mice. Toxicol Appl Pharmacol 1989;100:474-484 (Pubitemid 19253925)
22. 2+-calmodulin- dependent protein kinase II. Mol Cell Biol 2000;20:8103-8111
23. Gerber DJ, Pereira P, Huang SY, Pelletier C, Tonegawa S. Expression of αv and β3 integrin chains on murine lymphocytes. Proc Natl Acad Sci U S A 1996;93:14698-14703 (Pubitemid 26419031)
24. Halvorson MJ, Coligan JE, Sturmhofel K. The vitronectin receptor (αVβ3) as an example for the role of integrins in T lymphocyte stimulation. Immunol Res 1996;15:16-29. (Pubitemid 26142219)
25. Brando C, Shevach EM. Engagement of the vitronectin receptor (αVβ3) on murine T cells stimulates tyrosine phosphorylation of a 115-kDa protein. J Immunol 1995;154:2005-2011.
26. Huang S, Endo RI, Nemerow GR. Upregulation of integrins αvβ3 and αvβ5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery. J Virol 1995;69:2257-2263