Chapter 9 The Lambert-Eaton myasthenic syndrome

Handbook of Clinical Neurology

Volumn 91, Issue , 2008, Pages 273-283

  Sanders, Donald B ^a   Juel, Vern C ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; EATON LAMBERT SYNDROME; HUMAN; PATHOPHYSIOLOGY;

HUMANS; LAMBERT-EATON MYASTHENIC SYNDROME;

EID: 66049109677     PISSN: 00729752     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0072-9752(07)01509-6     Document Type: Review

References (67)

1. AAEM Quality Assurance Committee American Association of Electrodiagnostic Medicine. Practice parameter for repetitive nerve stimulation and single fiber EMG evaluation of adults with suspected myasthenia gravis or Lambert-Eaton myasthenic syndrome: summary statement. Muscle Nerve 24 (2001) 1236-1238
2. Anderson H.J., Churchill-Davidson H.C., and Richardson A.T. Bronchial neoplasm with myasthenia. Prolonged apnea after administration of succinylcholine. Lancet ii (1953) 1291-1293
3. Baker M.K., Low P.A., and McEvoy K.M. Quantification of autonomic dysfunction in Lambert-Eaton syndrome by composite autonomic scoring scale. Neurology 44 (1994) A220
4. Boerma C.E., Rommes J.H., van Leeuwen R.B., et al. Cardiac arrest following an iatrogenic 3,4-diaminopyridine intoxication in a patient with Lambert-Eaton myasthenic syndrome. J Toxicol Clin Toxicol 33 (1995) 249-251
5. Burns T.M., Russell J.A., LaChance D.H., et al. Oculobulbar involvement is typical with Lambert-Eaton myasthenic syndrome. Ann Neurol 53 (2003) 270-273
6. Chalk C.H., Murray N.M., Newsom-Davis J., et al. Response of the Lambert-Eaton myasthenic syndrome to treatment of associated small-cell lung carcinoma. Neurology 40 (1990) 1552-1556
7. Eaton L.M., and Lambert E.H. Electromyography and electric stimulation of nerves in diseases of the motor unit. JAMA 163 (1957) 1117-1124
8. Fukunaga H., Engel A.G., Osame M., et al. Paucity and disorganization of presynaptic membrane active zones in the Lambert-Eaton myasthenic syndrome. Muscle Nerve 5 (1982) 686-697
9. Fukunaga H., Engel A.G., Lang B., et al. Passive transfer of Lambert-Eaton myasthenic syndrome with IgG from man to mouse depletes the presynaptic membrane active zones. Proc Natl Acad Sci USA 80 (1983) 7636-7640
10. Fukuoka T., Engel A.G., Lang B., et al. Lambert-Eaton myasthenic syndrome: I. Early morphological effects of IgG on the presynaptic membrane active zones. Ann Neurol 22 (1987) 193-199
11. Fukuoka T., Engel A.G., Lang B., et al. Lambert-Eaton myasthenic syndrome: II. Immunoelectron microscopy localization of IgG at the mouse motor end-plate. Ann Neurol 22 (1987) 200-211
12. ++ on neuromuscular transmission in the Eaton-Lambert syndrome. Neurology 23 (1973) 977-980
13. Gutmann L., Crosby T.W., Takamori M., et al. The Eaton-Lambert syndrome and autoimmune disorders. Am J Med 53 (1972) 354
14. Harper C.M. Congenital myasthenic syndromes. In: Brown W.F., Bolton C.F., and Aminoff M.J. (Eds). Neuromuscular Function and Disease (2002), W.B. Saunders Company, Philadelphia 1687-1695
15. Harper C.M., and Lennon V.A. The Lambert-Eaton myasthenic syndrome. In: Kaminski H.J. (Ed). Current Clinical Neurology: Myasthenia Gravis and Related Disorders (2002), Humana Press, Totowa, NJ 269-291
16. Hutter O.F. Post-tetanic restoration of neuromuscular transmission blocked by d-tubocurarine. J Physiol 118 (1952) 216-227
17. Jenkyn L.R., Brooks P.L., Forcier R.J., et al. Remission of the Lambert-Eaton syndrome and small cell anaplastic carcinoma of the lung induced by chemotherapy and radiotherapy. Cancer 46 (1980) 1123-1127
18. Kanzato N., Motomura M., Suehara M., et al. Lambert-Eaton myasthenic syndrome with ophthalmoparesis and pseudoblepharospasm. Muscle Nerve 22 (1999) 1727-1730
19. Katz J.S., Wolfe G.I., Bryan W.W., et al. Acetylcholine receptor antibodies in the Lambert-Eaton myasthenic syndrome. Neurology 50 (1998) 470-475
20. Khurana R.K. Paraneoplastic autonomic dysfunction. In: Low P.A. (Ed). Clinical Autonomic Disorders (1993), Little, Brown Co., Boston 506-511
21. Khurana R.K., Koski C.L., and Mayer R.F. Autonomic dysfunction in Lambert-Eaton myasthenic syndrome. J Neurol Sci 85 (1988) 77-86
22. Kim Y.I. Passively transferred Lambert-Eaton syndrome in mice receiving purified IgG. Muscle Nerve 9 (1986) 523-530
23. Kobayashi H., Matsuoka R., Kitamura S., et al. Bronchogenic carcinoma with subacute cerebellar degeneration and Eaton-Lambert syndrome: an autopsy case. Jpn J Med 27 (1988) 203-206
24. Lambert E.H. General discussion. Ann N Y Acad Sci 505 (1987) 380-381
25. Lambert E.H., and Elmqvist D. Quantal components of end-plate potentials in the myasthenic syndrome. Ann N Y Acad Sci 183 (1971) 183-199
26. Lambert E.H., Rooke E.D., Eaton L.M., et al. Myasthenic syndrome occasionally associated with bronchial neoplasm: neurophysiologic studies. In: Viets H.R. (Ed). Myasthenia Gravis (1961), Charles C. Thomas, Springfield 362-410
27. Lang B., Newsom-Davis J., Wray D.W., et al. Autoimmune aetiology for myasthenic (Lambert-Eaton) syndrome. Lancet 2 (1981) 224-226
28. Lang B., Newsom-Davis J., Prior C., et al. Antibodies to motor nerve terminals: an electrophysiological study of a human myasthenic syndrome transferred to mouse. J Physiol 344 (1983) 335-345
29. Lang B., Johnston I., Leys K., et al. Autoantibody specificities in Lambert-Eaton myasthenic syndrome. Ann N Y Acad Sci 681 (1993) 382-393
30. Lennon V.A. Serological profile of myasthenia gravis and distinction from the Lambert-Eaton myasthenic syndrome. Neurology 48 (1997) S23-S27
31. Lennon V.A., Lambert E.H., Whittingham S., et al. Autoimmunity in the Lambert-Eaton syndrome. Muscle Nerve 5 (1982) S21-S25
32. Lennon V.A., Kryzer T.J., Griesmann G.E., et al. Calcium-channel antibodies in the Lambert-Eaton syndrome and other paraneoplastic syndromes. N Engl J Med 332 (1995) 1467-1474
33. Leys K., Lang B., Johnston I., et al. Calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome. Ann Neurol 29 (1991) 307-314
34. Maddison P., and Newsom-Davis J. Treatment for Lambert-Eaton myasthenic syndrome. Cochrane Database of Syst Rev (2003) CD003279
35. Maddison P., Newsom-Davis J., Mills K.R., et al. Favourable prognosis in Lambert-Eaton myasthenic syndrome and small-cell lung carcinoma. Lancet 353 (1999) 117-118
36. Maddison P., Lang B., Mills K., et al. Long term outcome in Lambert-Eaton myasthenic syndrome without lung cancer. J Neurol Neurosurg Psychiatry 70 (2001) 212-217
37. McEvoy K.M., Windebank A.J., Daube J.R., et al. 3,4-Diaminopyridine in the treatment of Lambert-Eaton myasthenic syndrome. N Engl J Med 321 (1989) 1567-1571
38. Nagel A., Engel A.G., Lang B., et al. Lambert-Eaton myasthenic syndrome IgG depletes presynaptic membrane active zone particles by antigenic modulation. Ann Neurol 24 (1988) 552-558
39. Nakao Y.K., Motomura M., Fukudome T., et al. Seronegative Lambert-Eaton myasthenic syndrome: study of 110 Japanese patients. Neurology 59 (2002) 1773-1775
40. Newsom-Davis J., Leys K., Vincent A., et al. Immunological evidence for the co-existence of the Lambert-Eaton myasthenic syndrome and myasthenia gravis in two patients. J Neurol Neurosurg Psychiatry 54 (1991) 452-453
41. NIH Consensus Conference Statement. The utility of therapeutic plasmapheresis for neurological disorders. JAMA 256 (1986) 1333-1337
42. Nilsson O., and Rosén I. The stretch reflex in the Eaton-Lambert syndrome, myasthenia gravis and myotonic dystrophy. Acta Neurol Scand 57 (1978) 350-357
43. Oh S.J., and Sher E. MG and LEMS overlap syndrome: case report with electrophysiological and immunological evidence. Clinic Neurophysiol 116 (2005) 1167-1171
44. Oh S.J., Kurokawa K., Claussen G.C., et al. Electrophysiological diagnostic criteria of Lambert-Eaton syndrome. Muscle Nerve 32 (2005) 515-520
45. O'Neill J.H., Murray N.M., and Newsom-Davis J. The Lambert-Eaton myasthenic syndrome. A review of 50 cases. Brain 111 (1988) 577-596
46. O'Suilleabhain P., Low P.A., and Lennon V.A. Autonomic Dysfunction in the Lambert-Eaton myasthenic syndrome: serologic and clinical correlates. Neurology 50 (1998) 88-93
47. Rich M.M., Teener J.W., and Bird S.J. Treatment of Lambert-Eaton syndrome with intravenous immunoglobulin. Muscle Nerve 20 (1997) 614-615
48. Sanders D.B. The effect of firing rate on neuromuscular jitter in Lambert-Eaton myasthenic syndrome. Muscle Nerve 15 (1992) 256-258
49. Sanders D.B. Clinical neurophysiology of disorders of the neuromuscular junction. J Clin Neurophysiol 10 (1993) 167-180
50. Sanders D.B. Lambert-Eaton myasthenic syndrome: clinical diagnosis, immune-mediated mechanisms, and update on therapy. Ann Neurol 37 S1 (1995) S63-S73
51. Sanders D.B., Massey J.M., Sanders L.L., et al. A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome. Neurology 54 (2000) 603-607
52. Sanders D.B. Electrophysiological study of disorders of the neuromuscular transmission. In: Aminoff M.J. (Ed). Electrodiagnosis in Clinical Neurology (2005), Elsevier/Churchill Livingstone, Philadelpia 335-355
53. Smith A.G., and Wald J. Acute ventilatory failure in Lambert-Eaton myasthenic syndrome and its response to 3,4-diaminopyridine. Neurology 46 (1996) 1143-1145
54. Streib E.W. Adverse effects of magnesium salt cathartics in a patient with the myasthenic syndrome (Lambert-Eaton syndrome). Ann Neurol 2 (1977) 175-176
55. Tim R.W., Massey J.M., and Sanders D.B. Lambert-Eaton myasthenic syndrome (LEMS). Clinical and electrodiagnostic features and response to therapy in 59 patients. Ann N Y Acad Sci 841 (1998) 823-826
56. Tim R.W., Massey J.M., and Sanders D.B. Lambert-Eaton myasthenic syndrome: diagnostic findings and response to treatment in 70 patients. In: Stålberg E.V., de Weerd A.W., and Zidar J. (Eds). 9th European Congress of Clinical Neurophysiology (1998), Moduzzi Editore, Bologna 329-334
57. Tim R.W., Massey J.M., and Sanders D.B. Lambert-Eaton myasthenic syndrome. Electrodiagnostic findings and response to treatment. Neurology 54 (2000) 2176-2178
58. Trontelj J.V., and Stålberg E. Single motor end-plates in myasthenia gravis and LEMS at different firing rates. Muscle Nerve 14 (1991) 226-232
59. Trontelj J.V., and Stålberg E. The effect of firing rate on neuromuscular jitter in Lambert-Eaton myasthenic syndrome: a reply. Muscle Nerve 15 (1992) 258
60. van den Bergh P., Kelly J.J., Carter B., et al. Intravascular contrast media and neuromuscular junction disorders. Ann Neurol 19 (1986) 206-207
61. Wirtz P.W., de Keizer R.J., de Visser M., et al. Tonic pupils in Lambert-Eaton myasthenic syndrome. Muscle Nerve 24 (2001) 444-445
62. Wirtz P.W., Smallegange T.M., Wintzen A.R., et al. Differences in clinical features between the Lambert-Eaton myasthenic syndrome with and without cancer: an analysis of 227 published cases. Clinic Neurol Neurosurg 104 (2002) 359-363
63. Wirtz P.W., Sotodeh M., Nijnuis M., et al. Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome. J Neurol Neurosurg Psychiatry 73 (2002) 766-768
64. Wirtz P.W., Bradshaw J., Wintzen A.R., et al. Associated autoimmune diseases in patients with the Lambert-Eaton myasthenic syndrome and their families. J Neurol 251 (2004) 1255-1259
65. Wirtz P.W., van Dijk J.G., van Doorn P.A., et al. The epidemiology of the Lambert-Eaton myasthenic syndrome in the Netherlands. Neurology 63 (2004) 397-398
66. Wirtz P.W., Wintzen A.R., and Verschuuren J.J. The Lambert-Eaton myasthenic syndrome has a more progressive course in patients with lung cancer. Muscle Nerve 32 (2005) 226-229
67. Yeh J.Z., Oxford C.H., Wu C.H., et al. Interactions of aminopyridines with potassium channels of squid axon membranes. Biophys J 16 (1976) 77-81