Two cases of discontinuation syndrome following cessation of memantine

Geriatrics and Gerontology International

Volumn 9, Issue 2, 2009, Pages 203-205

  Kwak, Yong Tae ^a   Han, Il Woo ^a   Suk, Seung Han ^b   Koo, Min Seong ^c  

^a Yong in Hyoja Geriatric Hospital   (South Korea)

^b Wonkwang University   (South Korea)

^c Catholic Kwandong University   (South Korea)

Author keywords

Cessation; Discontinuation syndrome; Memantine

Indexed keywords

CLONAZEPAM; LORAZEPAM; MEMANTINE; QUETIAPINE; RISPERIDONE; TRAZODONE;

AGED; AGGRESSION; ALZHEIMER DISEASE; ANXIETY DISORDER; ARTICLE; BEHAVIOR DISORDER; BRAIN ATROPHY; BRAIN DAMAGE; BRAIN HEMORRHAGE; BRAIN INFARCTION; CASE REPORT; CEREBRAL ARTERY DISEASE; COGNITIVE DEFECT; DELIRIUM; DELUSION; DRUG DOSE INCREASE; DRUG RESPONSE; DRUG WITHDRAWAL; FOLLOW UP; HEALTH INSURANCE; HUMAN; INSOMNIA; MALE; MEMORY DISORDER; MINI MENTAL STATE EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PARALYSIS; PERSONALITY DISORDER; PRIORITY JOURNAL; RETREATMENT; SLEEP DISORDER; VISUAL HALLUCINATION; WITHDRAWAL SYNDROME;

AGED; ALZHEIMER DISEASE; HUMANS; MALE; MEMANTINE; SUBSTANCE WITHDRAWAL SYNDROME; SYNDROME; TREATMENT OUTCOME;

EID: 66049101657     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/j.1447-0594.2009.00519.x     Document Type: Article

References (8)

1. Orgogozo JM, Rigaud AS, Stöffler A, Möbius HJ, Forette F. Efficacy and safety of memantine in patients with mild to moderate vascular dementia: A randomized placebo-controlled trial (MMM 300). Stroke 2002; 33: 1834-1839.
2. Roman GC, Tatemichi TK, Erkinjuntti T et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993; 43: 250-260.
3. Danysz W, Parsons CG, Mobius H-J, Stoffler A, Quack G. Neuroprotective and symptomatological action of memantine relevant for Alzheimer's disease: A unified glutamatergic hypothesis on the mechanism of action. Neurotox Res 2000; 2: 85-97.
4. Schatzberg AF, Haddad P, Kaplan EM et al. Serotonin reuptake inhibitor discontinuation syndrome: A hypothetical definition. Discontinuation Consensus panel. J Clin Psychiatry 1997; 58(Suppl 7): 5-10.
5. Black K, Shea C, Dursun S, Kutcher S. Selective serotonin reuptake inhibitor discontinuation syndrome: Proposed diagnostic criteria. J Psychiatry Neurosci 2000; 25: 255-261.
6. Singh S, Dudley C. Discontinuation syndrome following donepezil cessation. Int J Geriatr Psychiatry 2003; 18: 282-284.
7. Doody RS, Geldmacher DS, Gordon B, Perdomo CA, Pratt RD. Open-label, multicenter, phase 3 extension study of the safety and efficacy of donepezil in patients with Alzheimer's disease. Arch Neurol 2001; 58: 427-433.
8. Parsons CG, Stöffler A, Danysz W. Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse. Neuropharmacology 2007; 53: 699-723.