The importance of aromatic-type interactions in serotonin synthesis: Protein-ligand interactions in tryptophan hydroxylase and aromatic amino acid decarboxylase

Journal of Computational Chemistry

Volumn 30, Issue 7, 2009, Pages 1111-1115

  Hofto, Laura R ^a   Lee, Caroline E ^a   Cafiero, Mauricio ^a  

^a RHODES COLLEGE   (United States)

Author keywords

Aromatic; DFT; Dispersion; Enzyme; MP2; Protein

Indexed keywords

ACTIVE SITE; AROMATIC; AROMATIC AMINO ACID; AROMATIC LIGANDS; AROMATIC RESIDUES; AROMATIC SUBSTRATES; DECARBOXYLASE; DFT; ELECTRONIC INTERACTIONS; GRADIENT-CORRECTED DENSITY FUNCTIONAL THEORY; HYDROXYLASE; IN-SILICO; INTERACTION ENERGIES; MP2; PERTURBATION THEORY; PROTEIN FUNCTIONS; PROTEIN-LIGAND INTERACTIONS; SECOND ORDERS; SUBSTRATE BINDING;

AMINATION; AMINES; AMINO ACIDS; AROMATIZATION; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; CATALYSTS; CHELATION; DENSITY FUNCTIONAL THEORY; ENZYMES; LIGANDS; ORGANIC ACIDS; PERTURBATION TECHNIQUES; PROBABILITY DENSITY FUNCTION; SUBSTRATES;

AROMATIC COMPOUNDS;

AROMATIC HYDROCARBON; AROMATIC LEVO AMINO ACID DECARBOXYLASE; LIGAND; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

ARTICLE; BIOSYNTHESIS; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; ENZYME ACTIVE SITE; METABOLISM;

AROMATIC-L-AMINO-ACID DECARBOXYLASES; CATALYTIC DOMAIN; COMPUTER SIMULATION; HYDROCARBONS, AROMATIC; LIGANDS; MODELS, CHEMICAL; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

EID: 65949108263     PISSN: 01928651     EISSN: 1096987X     Source Type: Journal    
DOI: 10.1002/jcc.21139     Document Type: Article

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