Treponema pallidum, the stealth pathogen, changes, but how?: MicroCommentary

Molecular Microbiology

Volumn 72, Issue 5, 2009, Pages 1081-1086

  Radolf, Justin D ^a   Desrosiers, Daniel C ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENIC VARIATION; BACTERIAL MEMBRANE; DNA BINDING; DNA FOOTPRINTING; ESCHERICHIA COLI; GEL MOBILITY SHIFT ASSAY; HOST RESISTANCE; NONHUMAN; NOTE; NUCLEOTIDE REPEAT; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SYPHILIS; TRANSCRIPTOMICS; TREPONEMA PALLIDUM;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CYCLIC AMP RECEPTOR PROTEIN; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; TREPONEMA PALLIDUM;

ESCHERICHIA COLI; SPIROCHAETA; TREPONEMA PALLIDUM;

EID: 65949090945     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2009.06711.x     Document Type: Note

References (29)

1. Busby, S. Ebright, R.H. (1999) Transcription activation by catabolite activator protein (CAP). J Mol Biol 293 : 199 213. (Pubitemid 29516164)
2. Caimano, M.J., Iyer, R., Eggers, C.H., Gonzalez, C., Morton, E.A., Gilbert, M.A., et al. (2007) Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle. Mol Microbiol 65 : 1193 1217. (Pubitemid 47262822)
3. Centurion-Lara, A. (2006) Antigenic variation in Treponema pallidum. In Pathogenic Treponema: Molecular and Cellular Biology. Radolf, J.D. Lukehart, S.A. (eds). Norwich : Caister Acadmeic Press, pp. 267 284.
4. Centurion-Lara, A., Castro, C., Barrett, L., Cameron, C., Mostowfi, M., Van Voorhis, W.C. Lukehart, S.A. (1999) Treponema pallidum major sheath protein homologue TprK is a target of opsonic antibody and the protective immune response. J Exp Med 189 : 647 656. (Pubitemid 29193365)
5. Cox, D.L. Radolf, J.D. (2006) Metabolism of the Treponema. In Pathogenic Treponema: Molecular and Cellular Biology. Radolf, J.D. Lukehart, S.A. (eds). Norwich : Caister Acadmeic Press, pp. 61 100.
6. Desrosiers, D.C., Sun, Y.C., Zaidi, A.A., Eggers, C.H., Cox, D.L. Radolf, J.D. (2007) The general transition metal (Tro) and Zn(2+) (Znu) transporters in Treponema pallidum: analysis of metal specificities and expression profiles. Mol Microbiol 65 : 137 152. (Pubitemid 46934485)
7. Fraser, C.M., Norris, S.J., Weinstock, G.M., White, O., Sutton, G.G., Dodson, R., et al. (1998) Complete genome sequence of Treponema pallidum, the syphilis spirochaete. Science 281 : 375 388. (Pubitemid 28340777)
8. Giacani, L., Godornes, C., Puray-Chavez, M., Guerra-Giraldez, C., Trompa, M., Lukehart, S.A. Centurion-Lara, A. (2009) TP0262 is a modulator of promoter activity of tpr subfamily II genes of Treponema pallidum subsp. Pallidum Mol Microbiol 72 : 1087 1099.
9. Giacani, L., Hevner, K. Centurion-Lara, A. (2005) Gene organization and transcriptional analysis of the tprJ, tprI, tprG, and tprF loci in Treponema pallidum strains Nichols and Sea 81-4. J Bacteriol 187 : 6084 6093. (Pubitemid 41262805)
10. Giacani, L., Lukehart, S. Centurion-Lara, A. (2007) Length of guanosine homopolymeric repeats modulates promoter activity of subfamily II tpr genes of Treponema pallidum ssp. pallidum. FEMS Immunol Med Microbiol 51 : 289 301. (Pubitemid 47547502)
11. Gonzalez, C.F., Stonestrom, A.J., Lorca, G.L. Saier, M.H., Jr (2005) Biochemical characterization of phosphoryl transfer involving HPr of the phosphoenolpyruvate-dependent phosphotransferase system in Treponema denticola, an organism that lacks PTS permeases. Biochemistry 44 : 598 608. (Pubitemid 40105491)
12. Gorke, B. Stulke, J. (2008) Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat Rev Microbiol 6 : 613 624.
13. Gosset, G., Zhang, Z., Nayyar, S., Cuevas, W.A. Saier, M.H., Jr (2004) Transcriptome analysis of Crp-dependent catabolite control of gene expression in Escherichia coli. J Bacteriol 186 : 3516 3524. (Pubitemid 38661549)
14. Hazlett, K.R.O., Cox, D.L., Sikkink, R.A., Auch'ere, F., Rusnak, F. Radolf, J.D. (2002) Contribution of neelaredoxin to oxygen tolerance by Treponema pallidum. Meth Enzymol 353 : 140 156. (Pubitemid 34625588)
15. B- dependent general stress response in Bacillus subtilis and related Gram-positive bacteria. Annu Rev Microbiol 61 : 236. (Pubitemid 350058207)
16. Hengge-Aronis, R. (2002) Recent insights into the general stress response regulatory network in Escherichia coli. J Mol Microbiol Biotechnol 4 : 341 346. (Pubitemid 34256711)
17. Hubner, A., Yang, X., Nolen, D.M., Popova, T.G., Cabello, F.C. Norgard, M.V. (2001) Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway. Proc Natl Acad Sci U S A 98 : 12724 12729. (Pubitemid 33020013)
18. LaFond, R.E. Lukehart, S.A. (2006) Biological basis for syphilis. Clin Microbiol Rev 19 : 29 49. (Pubitemid 43157646)
19. Lukehart, S.A. (2004) Syphilis. In Harrison's Principles of Internal Medicine. Brauwald, E., Faucci, A.S., Hauser, S.L., Longo, D.L. Jameson, J.L. (eds). New York : McGraw-Hill, pp. 977 985.
20. Machius, M., Brautigam, C.A., Tomchick, D.R., Ward, P., Otwinowski, Z., Blevins, J.S. et al 2007) Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum: putative role for Tp0655 (TpPotD) as a polyamine receptor. J Mol Biol 373 : 681 694. (Pubitemid 47489786)
21. Norris, S.J. (2006) Antigenic variation with a twist - the Borrelia story. Mol Microbiol 60 : 1319 1322. (Pubitemid 43801425)
22. Norris, S.J. Weinstock, G.M. (2006) Comparative genomics of spirochaetes. In Pathogenic Treponema: Molecular and Cellular Biology. Radolf, J.D. Lukehart, S.A. (eds). Norwich : Caister Acadmeic Press, pp. 19 38.
23. Passner, J.M. Steitz, T.A. (1997) The structure of a CAP-DNA complex having two cAMP molecules bound to each monomer. Proc Natl Acad Sci U S A 94 : 2843 2847. (Pubitemid 127634966)
24. Radolf, J.D. (1995) Treponema pallidum and the quest for outer membrane proteins. Mol Microbiol 16 : 1067 1073.
25. Radolf, J.D., Hazlett, K.R.O. Lukehart, S.A. (2006) Pathogenesis of Syphilis. In Pathogenic Treponemes: Cellular and Molecular Biology. Radolf, J.D. Lukehart, S.A. (eds). Norwich : Caister Acadmeic Press, pp. 197 236.
26. Raivio, T.L. Silhavy, T.J. (2001) Periplasmic stress and ECF sigma factors. Annu Rev Microbiol 55 : 591 624. (Pubitemid 32978117)
27. Subramanian, G., Koonin, E.V. Aravind, L. (2000) Comparative genome analysis of the pathogenic spirochaetes Borrelia burgdorferi and Treponema pallidum. Infect Immun 68 : 1633 1648. (Pubitemid 30108567)
28. Warner, J.B. Lolkema, J.S. (2003) CcpA-dependent carbon catabolite repression in bacteria. Microbiol Mol Biol Rev 67 : 475 490. (Pubitemid 37549768)
29. Zheng, D., Constantinidou, C., Hobman, J.L. Minchin, S.D. (2004) Identification of the CRP regulon using in vitro and in vivo transcriptional profiling. Nucl Acids Res 32 : 5874 5893. (Pubitemid 39619170)