Improved pharmacokinetic and bioavailability support of drug discovery using serial blood sampling in mice

Journal of Pharmaceutical Sciences

Volumn 98, Issue 5, 2009, Pages 1877-1884

  Peng, Sean X ^a   Rockafellow, Beth A ^a   Skedzielewski, Tina M ^a   Huebert, Norman D ^a   Hageman, William ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Bioavailability; Discrete blood sampling; Drug transporters; Enterohepatic recirculation; Indinavir; Mouse; P450 enzymes; Pharmacokinetics; Rosuvastatin; Serial blood sampling

Indexed keywords

INDINAVIR; ROSUVASTATIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 65949090746     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21533     Document Type: Article

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