Coupling CARS with multiphoton fluorescence and high harmonic generation imaging modalities using a femtosecond laser source

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 7183, Issue , 2009, Pages

  Chena, Hongtao ^a   Slipchenkob, Mikhail N ^b   Zhub, Jiabin ^b   Buhmanc, Kimberly K ^a   Cheng, Ji Xin ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Coherent anti Stokes Raman scattering; Lipid droplets; Liver tissue; Multimodal; Nonlinear optical imaging

Indexed keywords

COHERENT ANTI-STOKES RAMAN SCATTERING; LIPID DROPLETS; LIVER TISSUE; MULTIMODAL; NONLINEAR OPTICAL IMAGING;

DROP FORMATION; FLUORESCENCE; GLYCEROL; HARMONIC ANALYSIS; HARMONIC GENERATION; LASERS; LIVER; MEDICAL IMAGING; NIOBIUM COMPOUNDS; OPTICAL FREQUENCY CONVERSION; OPTICAL IMAGE STORAGE; OPTICAL PARAMETRIC OSCILLATORS; PARAMETRIC OSCILLATORS; PULSED LASER APPLICATIONS; RAMAN SPECTROSCOPY; SCATTERING;

RAMAN SCATTERING;

EID: 65949090735     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.808223     Document Type: Conference Paper

References (29)

1. W. Denk, J. H. Strickler, and W. W. Webb, "Two-photon laser scanning fluorescence microscopy," Science 248, 73-76 (1990). (Pubitemid 20139273)
2. P. J. Campagnola, and L. M. Loew, "Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms," Nat. Biotech. 21, 1356-1360 (2003). (Pubitemid 37356622)
3. W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, "Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation," Proc. Natl. Acad. Sci. U. S. A. 100, 7075-7080 (2003). (Pubitemid 36706395)
4. Y. Barad, H. Eisenberg, M. Horowitz, and Y. Silberberg, "Nonlinear scanning laser microscopy by third harmonic generation," Appl. Phys. Lett. 70, 922-924 (1997). (Pubitemid 127638748)
5. J. Squier, M. Muller, G. Brakenhoff, and K. R. Wilson, "Third harmonic generation microscopy," Opt. Express 3, 315-324 (1998).
6. D. Debarre, W. Supatto, A.-M. Pena, A. Fabre, T. Tordjmann, L. Combettes, M.-C. Schanne-Klein, and E. Beaurepaire, "Imaging lipid bodies in cells and tissues using third-harmonic generation microscopy," Nat. Meth. 3, 47-53 (2006). (Pubitemid 43135349)
7. J.-X. Cheng, A. Volkmer, L. D. Book, and X. S. Xie, "An Epi-Detected Coherent Anti-Stokes Raman Scattering (E-CARS) Microscope with High Spectral Resolution and High Sensitivity," J. Phys. Chem. B 105, 1277-1280 (2001). (Pubitemid 33764132)
8. F. Ganikhanov, S. Carrasco, X. S. Xie, M. Katz, W. Seitz, and D. Kopf, "Broadly tunable dual-wavelength light source for coherent anti-Stokes Raman scattering microscopy," Opt. Lett. 31, 1292-1294 (2006). (Pubitemid 43901270)
9. M. Hashimoto, T. Araki, and S. Kawata, "Molecular vibration imaging in the fingerprint region by use of coherent anti-Stokes Raman scattering microscopy with a collinear configuration," Opt. Lett. 25, 17681-17770 (2000).
10. Y. Fu, H. Wang, R. Shi, and J.-X. Cheng, "Second harmonic and sum frequency generation imaging of fibrous astroglial filaments in ex vivo spinal tissues," Biophys. J. 92, 3251-3259 (2007). (Pubitemid 46684584)
11. H.-W. Wang, T. T. Le, and J.-X. Cheng, "Label-free imaging of arterial cells and extracellular matrix using a multimodal CARS microscope," Opt. Comm. 281, 1813-1822 (2008).
12. S. Tang, T. B. Krasieva, Z. Chen, G. Tempea, and B. J. Tromberg, "Effect of pulse duration on two-photon excited fluorescence and second harmonic generation in nonlinear optical microscopy," J. Biomed. Opt. 11, 020501-020503 (2006). (Pubitemid 44355063)
13. Y. Fu, H. Wang, T. B. Huff, R. Shi, and J.-X. Cheng, "Coherent anti-stokes Raman scattering imaging of myelin degradation reveals a calcium-dependent pathway in lyso-PtdCho-induced demyelination," J. Neurosci. Res. 85, 2870-2881 (2007). (Pubitemid 47523571)
14. A. Zumbusch, G. R. Holtom, and X. S. Xie, "Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering," Phys. Rev. Lett. 82, 4142 (1999). (Pubitemid 129689382)
15. T. Hellerer, A. M. K. Enejder, and A. Zumbusch, "Spectral focusing: High spectral resolution spectroscopy with broad-bandwidth laser pulses," Appl. Phys. Lett. 85, 25-27 (2004).
16. S. J. Smith, S. Cases, D. R. Jensen, H. C. Chen, E. Sande, B. Tow, D. A. Sanan, J. Raber, R. H. Eckel, and R. V. Farese, "Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat," Nat. Genet. 25, 87-90 (2000). (Pubitemid 30257043)
17. X. Nan, J.-X. Cheng, and X. S. Xie, "Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy," J. Lipid Res. 44, 2202-2208 (2003). (Pubitemid 37509636)
18. J.-X. Cheng, and X. S. Xie, "Green's function formulation for third-harmonic generation microscopy," J. Opt. Soc. Am. B 19, 1604-1610 (2002).
19. S. Huang, A. A. Heikal, and W. W. Webb, "Two-photon fluorescence spectroscopy and microscopy of NAD(P)H and flavoprotein," Biophys. J. 82, 2811-2825 (2002). (Pubitemid 34441317)
20. M. D. Duncan, J. Reintjes, and T. J. Manuccia, "Scanning coherent anti-Stokes Raman microscope," Opt. Lett. 7, 350-352 (1982).
21. E. O. Potma, D. J. Jones, J.-X. Cheng, X. S. Xie, and J. Ye, "High-sensitivity coherent anti-Stokes Raman scattering microscopy with two tightly synchronized picosecond lasers," Opt. Lett. 27, 1168-1170 (2002).
22. C. L. Evans, E. O. Potma, M. Puoris'haag, D. Cote, C. P. Lin, and X. S. Xie, "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy," Proc. Natl. Acad. Sci. U. S. A. 102, 16807-16812 (2005). (Pubitemid 41688858)
23. N. Dudovich, D. Oron, and Y. Silberberg, "Single-pulse coherently controlled nonlinear Raman spectroscopy and microscopy," Nature 418, 512-514 (2002).
24. S.-H. Lim, A. G. Caster, and S. R. Leone, "Single-pulse phase-control interferometric coherent anti-Stokes Raman scattering spectroscopy," Phys. Rev. A 72, 041803 (2005).
25. H. N. Paulsen, K. M. Hilligse, J. Thøgersen, S. R. Keiding, and J. J. Larsen, "Coherent anti-Stokes Raman scattering microscopy with a photonic crystal fiber based light source," Opt. Lett. 28, 1123-1125 (2003).
26. T. W. Kee, and M. T. Cicerone, "Simple approach to one-laser, broadband coherent anti-Stokes Raman scattering microscopy," Opt. Lett. 29, 2701-2703 (2004).
27. H. Kano, and H.-o. Hamaguchi, "Ultrabroadband (> 2500 cm-1) multiplex coherent anti-Stokes Raman scattering microspectroscopy using a supercontinuum generated from a photonic crystal fiber," Appl. Phys. Lett. 86, 121113-1121113 (2005).
28. G. I. Petrov, and V. Yakovlev, "Enhancing red-shifted white-light continuum generation in optical fibers for applications in nonlinear Raman microscopy," Opt. Express 13, 1299-1306 (2005).
29. Y. Fu, H. Wang, R. Shi, and J.-X. Cheng, "Characterization of photodamage in coherent anti-Stokes Raman scattering microscopy," Opt. Express 14, 3942-3951 (2006).