Sporadic obstructive hydrocephalus in Aqp4 null mice

Journal of Neuroscience Research

Volumn 87, Issue 5, 2009, Pages 1150-1155

  Feng, Xuechao ^a   Papadopoulos, Marios C ^b   Liu, Jun ^a   Li, Lihua ^a   Zhang, Di ^a   Zhang, Hongguo ^a   Verkman, A S ^c   Ma, Tonghui ^a  

^a NORTHEAST NORMAL UNIVERSITY   (China)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aqp4 hydrocephalus; Aquaporin; Aqueduct stenosis; Ependyma

Indexed keywords

AQUAPORIN 4; EVANS BLUE;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN AQUEDUCT; BRAIN CELL; BRAIN SIZE; BRAIN VENTRICLE; CONGENITAL HYDROCEPHALUS; CONTROLLED STUDY; GENE DELETION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; HETEROZYGOTE; INTRACRANIAL PRESSURE; KNOCKOUT MOUSE; MORTALITY; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AQUAPORIN 4; BLOOD-BRAIN BARRIER; CEREBRAL AQUEDUCT; CEREBRAL VENTRICLES; CONSTRICTION, PATHOLOGIC; EPENDYMA; EVANS BLUE; EXTRAVASATION OF DIAGNOSTIC AND THERAPEUTIC MATERIALS; GENETIC PREDISPOSITION TO DISEASE; HYDROCEPHALUS; INJECTIONS, INTRAVENTRICULAR; INTRACRANIAL PRESSURE; MICE; MICE, KNOCKOUT;

EID: 65949086792     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21927     Document Type: Article

References (19)

1. Bloch O, Papadopoulos MC, Manley GT, Verkman AS. 2005. Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess. J Neurochem 95:254-262.
2. Bloch O, Auguste KI, Manley GT, Verkman AS. 2006. Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. J Cereb Blood Flow Metab 26:1527-1537.
3. Bruni JE. 1998. Ependymal development, proliferation, and functions: a review. Microsc Res Tech 41:2-13.
4. Crews L, Wyss-Coray T, Masliah E. 2004. Insights into the pathogenesis of hydrocephalus from transgenic and experimental animal models. Brain Pathol 14:312-316.
5. Fan Y, Zhang J, Sun XL, Gao L, Zeng XN, Ding JH, Cao C, Niu L, Hu G. 2005. Sex- and region-specific alterations of basal amino acid and monoamine metabolism in the brain of aquaporin-4 knockout mice. J Neurosci Res 82:458-464.
6. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. 1997. Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest 100:957-962.
7. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS. 2000. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6:159-163.
8. Mao X, Enno TL, Del Bigio MR. 2006. Aquaporin 4 changes in rat brain with severe hydrocephalus. Eur J Neurosci 23:2929-2936.
9. Mathew TC. 2008. Regional analysis of the ependyma of the third ventricle of rat by light and electron microscopy. Anat Histol Embryol 37:9-18.
10. Nielsen S, Nagelhus EA, Amiry-Moghaddam M, Bourque C, Agre P, Ottersen OP. 1997. Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci 17:171-180.
11. Oi S, Yamada H, Sato O, Matsumoto S. 1996. Experimental models of congenital hydrocephalus and comparable clinical problems in the fetal and neonatal periods. Childs Nerv Syst 12:292-302.
12. Papadopoulos MC, Verkman AS. 2005. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. J Biol Chem 280:13906-13912.
13. Papadopoulos MC, Manley GT, Krishna S, Verkman AS. 2004. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J 18:1291-1293.
14. Rash JE, Yasumura T, Hudson CS, Agre P, Nielsen S. 1998. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proc Natl Acad Sci U S A 95:11981-11986.
15. Shen XQ, Miyajima M, Ogino I, Arai H. 2006. Expression of the water-channel protein aquaporin 4 in the H-Tx rat: possible compensatory role in spontaneously arrested hydrocephalus. J Neurosurg 105(6 suppl):459-464.
16. Tait MJ, Saadoun S, Bell BA, Papadopoulos MC. 2008. Water movements in the brain: role of aquaporins. Trends Neurosci 31:37-43.
17. Verkman AS, Binder DK, Bloch O, Auguste K, Papadopoulos MC. 2006. Three distinct roles of aquaporin-4 in brain function revealed by knockout mice. Biochim Biophys Acta 1758:1085-1093.
18. Wagner C, Batiz LF, Rodriguez S, Jimenez AJ, Paez P, Tome M, Perez-Figares JM, Rodriguez EM. 2003. Cellular mechanisms involved in the stenosis and obliteration of the cerebral aqueduct of hyh mutant mice developing congenital hydrocephalus. J Neuropathol Exp Neurol 62:1019-1040.
19. Zhou J, Kong H, Hua X, Xiao M, Ding J, Hu G. 2008. Altered blood-brain barrier integrity in adult aquaporin-4 knockout mice. Neuroreport 19:1-5.